The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons

Journal of Neurochemistry

Volumn 79, Issue 5, 2001, Pages 1033-1038

  Michelhaugh, Sharon K ^a   Fiskerstrand, Carolyn ^b   Lovejoy, Elizabeth ^b   Bannon, Michael J ^a,d   Quinn, John P ^c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d 2309 Scott Hall ^*  (United States)

Author keywords

Biolistic transfection; Gene expression; GFP; Organotypic slice culture; VNTR

Indexed keywords

DOPAMINE; DOPAMINE TRANSPORTER; SEROTONIN; SEROTONIN TRANSPORTER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL IMMORTALIZATION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DNA SEQUENCE; DOPAMINERGIC NERVE CELL; ELECTROPHORETIC MOBILITY; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MESENCEPHALON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; TANDEM REPEAT; TRANSCRIPTION REGULATION; VARIABLE NUMBER OF TANDEM REPEAT;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MINISATELLITE REPEATS; NERVE TISSUE PROTEINS; NEURONS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0035213290     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00647.x     Document Type: Article

References (20)

1. Neurotransmitter transporters as molecular targets for addictive drugs
2. The dopamine transporter: Potential involvement in neuropsychiatric disorders
3. Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder
4. Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder
5. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells
6. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter
7. Genotype influences in vivo dopamine transporter availability in human striatum
8. Prediction of dopamine transporter binding availability by genotype: A preliminary report
9. Organization of the human serotonin transporter gene
10. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo
11. Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients
12. Characterisation of potential regulatory elements within the rat preprotachykinin - A promoter
13. Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: Implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders
14. VNTR (variable number of tandem repeat) sequences as transcriptional, translational, or functional regulators
15. The autoimmune antigen Ku is enriched on oligonucleotide columns distinct from those containing the octamer binding protein DNA consensus sequence
16. Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism
17. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos
18. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR
19. Human dopamine transporter gene: Coding region conservation among normal. Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations
20. Real-time analysis of preprotachykinin promoter activity in single cortical neurons