Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk

Psychological Medicine

Volumn 29, Issue 5, 1999, Pages 1069-1081

  Heath, Andrew C ^a   Madden, P A F ^a   Bucholz, K K ^a   Dinwiddie, S H ^a   Slutske, W S ^a   Bierut, L J ^a   Rohrbaugh, J W ^a   Statham, D J ^a   Dunne, M P ^a   Whitfield, J B ^a   Martin, N G ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; AUSTRALIA; BODY EQUILIBRIUM; DRINKING BEHAVIOR; FEMALE; FOLLOW UP; GENETIC RISK; HERITABILITY; HUMAN; HUMAN EXPERIMENT; INHERITANCE; INTERVIEW; MALE; MONOZYGOTIC TWINS; NORMAL HUMAN; PARENT; RISK ASSESSMENT; TELEPHONE; TWINS;

ADULT; ALCOHOLISM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; RISK ASSESSMENT; SEX FACTORS;

EID: 0032885516     PISSN: 00332917     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0033291799008909     Document Type: Article

References (48)

1. Bauer, L. O. & Hasselbrock, V. M. (1993). EEG, autonomic, and subjective correlates of the risk for alcoholism: an examination of the effects of anti-social personality disorder and a family history of alcoholism. Journal of Studies on Alcohol 54, 577-589.
2. Behar, D., Berg, C., Rapoport, J. L., Nelson, W., Linnoila, M., Cohen, M., Bozevich, C. & Marshall, T. (1983). Behavioral and physiological effects of ethanol in high-risk and control children: a pilot study. Alcoholism: Clinical and Experimental Research 7, 404-410.
3. Bierut, L. J., Heath, A. C., Bucholz, K. K., Dinwiddie, S. H., Madden, P. A. F., Statham, D. J., Dunne, M. P. & Martin, N. G. (1999). Major depressive disorder in a community-based twin sample : are there different genetic and environmental contributions for men and women. Archives of General Psychiatry 56, 557-563.
4. Bucholz, K. K., Cloninger, C. R., Dinwiddie, S. H., Hesselbrock, V. M., Nurnberger, J. I., Reich, T., Schmidt, I. & Schuckit, M. A. (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report of the reliability of the SSAGA. Journal of Studies on Alcohol 55, 149-158.
5. Cadoret, R. J., Cain, C. A., Troughton, E. & Heywood, E. (1985). Alcoholism and antisocial personality. Interrelationships, genetic and environmental factors. Archives of General Psychiatry 42, 161-167.
6. Cadoret, R. J., Troughton, E. & O'Gorman, T. W. (1987). Genetic and environmental factors in alcohol abuse and antisocial personality. Journal of Studies on Alcohol 48, 1-8.
7. Crowe, R. R. (1974). An adoption study of antisocial personality. Archives of General Psychiatry 31, 785-791.
8. Efron, B. & Tibshirani, R. (1986). Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy. Statistical Science 1, 54-77.
9. Goodwin, D. W., Schulsinger, F., Hermansen, L., Guze, S. B. & Winokur, G. (1973). Alcohol problems in adoptees raised apart from alcoholic biological parents. Archives of General Psychiatry 28, 238-243.
10. Grove, W. M., Eckert, E. D., Heston, L., Bouchard, T. J. Jr., Segal, N. & Lykken, D. T. (1990). Heritability of substance abuse and antisocial behavior : a study of monozygotic twins reared apart. Biological Psychiatry 27, 1293-1304.
11. Heath, A. C. (1995). Genetic influences on alcoholism risk? A review of adoption and twin studies. Alcohol Health and Research World 19, 166-171.
12. Heath, A. C. & Martin, N. G. (1992). Genetic differences in psychomotor performance decrement after alcohol: a multivariate analysis. Journal of Studies on Alcohol 53, 262-271.
13. Heath, A. C., Slutske, W. S. & Madden, P. A. F. (1997a). Gender differences in the genetic contribution to alcoholism risk and to alcohol consumption patterns. In Gender and Alcohol (ed. R. W. Wilsnack and S. C. Wilsnack), pp. 114-149. Rutgers University Press: Rutgers, NJ.
14. Heath, A. C., Bucholz, K. K., Madden, P. A. F., Dinwiddie, S. H., Slutske, W. S., Bierut, L. J., Statham, D. J., Dunne, M. P., Whitfield, J. & Martin, N. G. (1997b). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychological Medicine 27, 1381-1396.
15. Heath, A. C., Madden, P. A. F. & Martin, N. G. (1998). Assessing the effects of cooperation bias and attrition in behavioral genetic research using data-weighting. Behavior Genetics 28, 415-427.
16. Hegedus, A. M., Tarter, R. E., Hill, S. Y., Jacob, T. & Winsten, N. E. (1984). Static ataxia: a possible marker for alcoholism. Alcoholism: Clinical and Experimental Research 8, 580-582.
17. Jardine, R., Martin, N. G. & Henderson, A. S. (1984). Genetic covariation between neuroticism and the symptoms of anxiety and depression. Genetic Epidemiology 1, 89-107.
18. Kendler, K. S., Heath, A. C., Martin, N. G. & Eaves, L. J. (1986). Symptoms of anxiety and depression in a volunteer twin population : the etiologic role of genetic and environmental factors. Archives of General Psychiatry 43, 213-221.
19. Kendler, K. S., Heath, A. C., Neale, M. C., Kessler, R. C. & Eaves, L. J. (1993). Alcoholism and major depression in women: a twin study of the causes of comorbidity. Archives of General Psychiatry 500, 690-698.
20. Kendler, K. S., Walters, E. E., Neale, M. C., Kessler, R. C., Heath, A. C. & Eaves, L. J. (1995). The structure of the genetic and environmental risk factors for six major psychiatric disorders in women: phobia, generalized anxiety disorder, panic disorder, bulimia, major depression and alcoholism. Archives of General Psychiatry 52, 374-383.
21. Kessler, R. C., Nelson, C. B., McGonalge, K. A., Edlund, M. J., Frank, R. G. & Leaf, P. J. (1996). The epidemiology of cooccurring addictive and mental disorders; implications for prevention and service utilization. American Journal of Orthopsychiatry 66, 17-31.
22. Lex, B. W., Lukas, S. E., Greenwald, N. E. & Mendelson, J. H. (1988). Alcohol-induced changes in body sway in women at risk for alcoholism: a pilot study. Journal of Studies on Alcohol 49, 346-356.
23. Lipscomb, T. R., Carpenter, J. A. & Nathan, P. E. (1979). Static ataxia: a predictor of alcoholism? British Journal of Addictions 74, 289-294.
24. Long, J. C., Knowler, W. C., Hanson, R. L., Robin, R. W., Urbanek, M., Moore, E., Bennett, P. H. & Goldman, D. (1998). Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. American Journal of Medical Genetics (Neuropsychiatric Genetics) 81, 216-221.
25. McCaul, M. E., Turkkan, J. S., Svikis,D. S. & Bigelow, G. E. (1991). Alcohol and secobarbital effects as a function of familial alcoholism: extended intoxication and increased withdrawal effects. Alcoholism: Clinical and Experimental Research 15, 94-101.
26. McGue, M. (1994). Genes, environment and the etiology of alcoholism. In The Development of Alcohol Problems: Exploring the Biopsychosocial Matrix of Risk (ed. R. Zucker, G. Boyd and J. Howard), pp. 1-4. US Department of Health and Human Services: Rockville, MD.
27. Martin, N. G., Perl, J., Oakeshott, J. G., Gibson, J. B., Starmer, G. A. & Wilks, A. V. (1985a). A twin study of ethanol metabolism. Behavior Genetics 15, 93-109.
28. Martin, N. G., Oakeshott, J. G., Gibson, J. B., Starmer, G. A., Perl, J. & Wilks, A. V. (1985b). A twin study of psychomotor and physiological responses to an acute dose of alcohol. Behavior Genetics 15, 305-347.
29. Nagoshi, C. T. & Wilson, J. R. (1987). Influence of family alcoholism history on alcohol metabolism, sensitivity, and tolerance. Alcoholism: Clinical and Experimental Research 11, 392-398.
30. Neale, M. C. (1998). Mx: Statistical Modeling. Department of Psychiatry, Virginia Commonwealth University. Richmond, VA.
31. Neale, M. C. & Martin, N. G. (1989). The effects of age, sex, and genotype on self-report drunkenness following a challenge dose of alcohol. Behavior Genetics 19, 63-78.
32. Neale, M. C. & Cardon, L. R. (1992). Methodology for Genetic Studies of Twins and Families, NATO ASI Series. Kluwer Academic Publishers: Dordrecht, The Netherlands.
33. O'Malley, S. S. & Maisto, S. A. (1985). Effects of family drinking history and expectancies on responses to alcohol in men. Journal of Studies on Alcohol 46, 289-297.
34. Pickens, R. W., Svikis, D.S. & LaBuda, M. C. (1995). Common genetic mechanisms in alcohol, drug and mental disorder comorbidity. Drug Alcohol Dependence 39, 129-138.
35. Pollock, V. E. (1992). Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics. American Journal of Psychiatry 149 1534-1538.
36. Regier, D. A., Farmer, M. E., Rae, D. S., Locke, B. Z., Keith, S. J., Judd, L. L. & Goodwin, F. K. (1990). Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment Area (ECA) study. Journal of the American Medical Association 264, 2511-2518.
37. Reich, T., Edenberg, H. J., Goate, A., Williams, J. T., Rice, J. P., van Eerdewegh, P., Foroud, T., Hesselbrock, V., Schuckit, M. A., Bucholz, K., Projesz, B., Li, T.-K., Conneally, M., Nurnberger, J., Tischfield, J. A., Crowe, R. R., Cloninger, C. R., Wu, W., Shears, S., Carr, K., Crose, C., Willig, C. & Begleiter, H. (1998). Genomewide search for genes affecting the risk for alcohol dependence. American Journal of Medical Genetics (Neuropsychiatric Genetics) 81, 207-215.
38. Rosenbaum, P. R. & Rubin, D. B. (1983). The central role of the propensity score in observational studies for causal effects. Biometrika 70, 41-55.
39. SAS Institute Inc. (1990). SAS/STAT User's Guide, Version 6, Fourth Edition. SAS Institute, Inc.: Cary, NC.
40. Schuckit, M. A. (1984a). Subjective responses to alcohol in sons of alcoholics and control subjects. Archives of General Psychiatry 41 879-884.
41. Schuckit, M. A. (1984b). Differences in plasma cortisol after ingestion of ethanol in sons of alcoholics and controls: preliminary results. Journal of Clinical Psychiatry 45, 374-376.
42. Schuckit, M. A. (1985). Ethanol-induced changes in body sway in men at high alcoholism risk. Archives of General Psychiatry 42 375-379.
43. Schuckit, M. A. & Smith, T. (1996). An 8-year follow-up of 450 sons of alcoholic and control subjects. Archives of General Psychiatry 53, 202-210.
44. Schulsinger, F. (1972). Psychopathy: heredity and environment. International Journal of Mental Health 1, 190-206.
45. Slutske, W. S., Heath, A. C., Madden, P. A. F., Bucholz, K. K., Dinwiddie, S. H., Dunne, M. P., Statham, D. J. & Martin, N. G. (1996). Reliability and reporting biases for perceived parental history of alcohol problems: agreement between twins and differences between discordant pairs. Journal of Studies on Alcohol 57, 387-395.
46. Slutske, W. S., Heath, A. C., Dinwiddie, S. H., Madden, P. A. F., Bucholz, K. K., Dunne, M. P., Statham, D. J. & Martin, N. G. (1998). Common genetic risk factors for conduct disorder and alcohol dependence. Journal of Abnormal Psychology 107, 363-374.
47. Stata Corp. (1997). Stata Statistical Software: Release 5-0. Stata Corporation: College Station, TX.
48. True, W. R., Heath, A. C., Scherrer, J. F., Xian, H., Lin, N., Eisen, S. A., Lyons, M. J., Goldberg, J. & Tsuang, M. (1999). Interrelationship of the genetic and environmental influences on conduct disorder, alcohol and marijuana dependence symptoms. American Journal of Medical Genetics (Neuropsychiatric Genetics) (in the press).