Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence

Neuroscience Letters

Volumn 410, Issue 1, 2006, Pages 1-5

  Samochowiec, Jerzy ^a   Kucharska Mazur, Jolanta ^a   Grzywacz, Anna ^a   Jabłoński, Marcin ^a   Rommelspacher, Hans ^b   Samochowiec, Agnieszka ^a,c   Sznabowicz, Mariusz ^a   Horodnicki, Jan ^a   Sagan, Leszek ^a   Pełka Wysiecka, Justyna ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF SZCZECIN   (Poland)

Author keywords

Alcohol dependence; Case control study; Genetics; Polymorphisms; TDT

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; SEROTONIN TRANSPORTER;

ADULT; ALCOHOLISM; ALLELE; ANXIETY; ARTICLE; COGNITION; CONTROLLED STUDY; DNA POLYMORPHISM; DOPAMINERGIC SYSTEM; DYSPHORIA; ETHNIC DIFFERENCE; FAMILY HISTORY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHARMACOGENOMICS; PHENOTYPE; POLAND; POPULATION GENETICS; PRIORITY JOURNAL; PROMOTER REGION; STATISTICAL SIGNIFICANCE; STRESS;

ADULT; ALCOHOLISM; ALLELES; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; METHIONINE; MIDDLE AGED; MINISATELLITE REPEATS; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D2; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; VALINE;

EID: 33750526036     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.05.005     Document Type: Article

References (46)

1. Arinami T., Gao M., Hamaguchi H., and Toru M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum. Mol. Genet. 6 (1997) 577-582
2. Barr C., and Kidd K. Population frequencies of the A1 allele at the dopamine D2 receptor locus. Biol. Psychiatry 34 (1993) 204-209
3. Blomqvist O., Gelernter J., and Kranzler H. Family-based study of DRD2 alleles in alcohol and drug dependence. Am. J. Med. Genet. 96 (2000) 659-664
4. Bowirrat A., and Oscar-Berman M. Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome. Am. J. Med. Genet. B Neuropsychiatr. Genet. 132 (2005) 29-37
5. Connor J.P., Young R.M., Lawford B.R., Ritchie T.L., and Noble E.P. D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence. Eur. Psychiatry 17 (2002) 17-23
6. Dodd P.R., Foley P.F., Buckley S.T., Eckert A.L., and Innes D.J. Genes and gene expression in the brain of the alcoholic. Addict. Behav. 29 (2004) 1295-1309
7. Enoch M. Pharmacogenomics of alcohol response and addiction. Am. J. Pharmacogenomics 4 (2003) 3217-3232
8. U. Finckh, In: D. Agarwal, H. Seitz (Eds.), Alcohol in health and disease, Copyright by Marcel Dekker, Inc, New York-Basel, (2001) s.163.
9. Finckh U., Rommelspacher H., Kuhn S., Dufeu P., Otto G., Heinz A., Dettling M., Giraldo-Velasquez M., Pelz J., Graf K.J., Harms H., Sander T., Schmidt L.G., and Rolfs A. Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism. Pharmacogenetics 7 (1997) 271-281
10. Foley P.F., Loh E.W., Innes D.J., Williams S.M., Tannenberg A.E., Harper C.G., and Dodd P.R. Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. Ann. N.Y. Acad. Sci. 1025 (2004) 39-46
11. Geijer T., Neiman J., Rydberg U., and Terenius L. Dopamine D2-receptor gene polymorphisms in Scandinavian chronic alcoholics. Eur. Arch. Psychiatry Clin. Neurosci. 244 (1994) 26-32
12. Goldman D., Oroszi G., O'Malley S., and Anton R. COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms. J. Stud. Alcohol. Suppl. 15 (2005) 56-64
13. Hallikainen T., Hietala J., Kauhanen J., Pohjalainen T., Syvalahti E., Salonen J.T., and Tiihonen J. Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males. Am. J. Med. Genet. A 119 (2003) 152-155
14. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., and Lesch K.P. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66 (1996) 2621-2624
15. Heinz A., Goldman D., Gallinat J., Schumann G., and Puls I. Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. Psychopharmacology (Berl) 174 (2004) 561-570
16. Kidd K., Morar B., Castiglione C., Zhao H., Pakstis A., Speed W., Bonne-Tamir B., Lu R., Goldman D., Lee Ch., Nam Y.S., Grandy D., Jenkins T., and Kidd J. A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum. Genet. 103 (1998) 211-227
17. Kidd K., Pakstis A., Castiglione C., Kidd J., Speed W., Goldman D., Knowler W., Lu R., and Bonne-Tamir B. DRD2 haplotypes containing the TaqI A1 allele: implications for alcoholism research. Alcoholism: Clin. Exp. Res. 20 4 (1996) 697-705
18. Kohnke M.D., Wiatr G., Kolb W., Kohnke A.M., Schick S., and Lutz U. Plasma homovanillic acid: a significant association with alcoholism is independent of a functional polymorphism of the human catechol-O-methyltransferase gene. Neuropsychopharmacology 28 (2003) 1004-1010
19. Konishi T., Luo H.R., Calvillo M., Mayo M.S., Lin K.M., and Wan Y.J. ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. Alcohol. Clin. Exp. Res. 28 (2004) 1145-1152
20. Lachman H.M., Papolos D.F., Saqito T., Yu Y.M., Szumlanski C.L., and Weinshilboum R.M. Human catechol-O-methyltranferase pharmacogenetics: description of functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6 (1996) 243-250
21. Laine T.P., Ahonen A., Rasanen P., Pohjalainen T., Tiihonen J., and Hietala J. The A1 allele of the D2 dopamine receptor gene is associated with high dopamine transporter density in detoxified alcoholics. Alcohol Alcohol. 36 (2001) 262-265
22. Lesch O.M., Dietzel M., Musalek M., Walter H., and Zeiler K. The course of alcoholism. Long-term prognosis in different types. Forensic Sci. Int. 36 (1988) 121-138
23. Limosin F., Loze J.Y., Boni C., Fedeli L.P., Hamon M., Rouillon F., Ades J., and Gorwood P. The A9 allele of the dopamine transporter gene increases the risk of visual hallucinations during alcohol withdrawal in alcohol-dependent women. Neurosci. Lett. 362 (2004) 91-94
24. Lucht M., Kuehn K., Schroeder W., Armbruster J., Abraham G., Schattenberg A., Herrmann F.H., and Freyberger H.J. Influence of the dopamine D2 receptor (DRD2) exon 8 genotype on efficacy of tiapride and clinical outcome of alcohol withdrawal. Pharmacogenetics 11 (2001) 647-653
25. Meyer-Lindenberg A., Kohn P.D., Kolachana B., Kippenhan S., McInerney-Leo A., Nussbaum R., Weinberger D.R., and Berman K.F. Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat. Neurosci. 8 (2005) 594-596
26. Miller S., Dykes D., and Plesky H. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16 (1988) 1215
27. Munafo M.R., Clark T., and Flint J. Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Mol. Psychiatry 10 (2005) 415-419
28. Munafo M.R., Johnstone E.C., Welsh K.I., and Walton R.T. Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers. Pharmacogenomics J. 5 (2005) 96-101
29. Munafo M.R., Lingford-Hughes A.R., Johnstone E.C., and Walton R.T. Association between the serotonin transporter gene and alcohol consumption in social drinkers. Am. J. Med. Genet. B 135 (2005) 10-14
30. Noble E., Zhang X., Ritchie T., and Sparkes R. Haplotypes at the DRD2 locus and severe alcoholism. Am. J. Med. Genet. 96 (2000) 622-631
31. Noble E.P. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am. J. Med. Genet. B Neuropsychiatr. Genet. 116 (2003) 103-125
32. Oroszi G., and Goldman D. Alcoholism: genes and mechanisms. Pharmacogenomics 5 (2004) 1037-1048
33. Ploski R., Wozniak W., Pawlowski R., Monies D.M., Branicki W., Kupiec T., Kloosterman A., Dobosz T., Bosch E., Nowak M., Lessig R., Jobling M.A., Roewer L., and Kayser M. Homogeneity and distinctiveness of Polish paternal lineages revealed by Y chromosome microsatellite haplotype analysis. Hum. Genet. 110 (2002) 592-600
34. Reck B., Mukhopadhyay N., Tsai H., and Weeks D. Analysis of alcohol dependence phenotype in the COGA families using covariates to detect linkage. BMC Genet. 6 Suppl. 1 (2005) 143 [Epub ahead of print]
35. Robins L., Wing J., Wittchen H., Helzer J., Babor T., and Burke J. The Composite International Diagnostic Interview. An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch. Gen. Psychiatry 45 (1988) 1069-1077
36. Ruiz-Narvaez E.A., and Campos H. Transmission disequilibrium test (TDT). Eur. J. Hum. Genet. 12 (2004) 1069-1077
37. Samochowiec J., Ladehoff M., Pelz J., Smolka M., Schmidt L.G., Rommelspacher H., and Finckh U. Predominant influence of the 3′-region of dopamine D2 receptor gene (DRD2) on the clinical phenotype in German alcoholics. Pharmacogenetics 10 (2000) 471-475
38. Sander T., Harms H., Podschus J., Finckh U., Nickel B., and Bander R. Dopamine D1-,D2-, and D3 receptor genes in alcohol dependence. Psychiatric. Genet. 5 (1995) 171-176 38
39. Sander H., Harms H., Podschus J., Finckh U., Nickel B., Rolfs A., Rommelspacher H., and Schmidt L.G. Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium. Biol. Psychiatry 41 (1997) 299-304
40. SAS Institute: SAS/STST User's Guide, Release 6.03 edition SAS Institute, Cary, NC, 1988.
41. Schmidt L., Harms H., Kuhn S., Rommelspacher H., and Sander T. Modification of alcohol withdrawal by the A9 allele of the dopamine transporter gene. Am. J. Psychiatry 155 (1998) 474-478
42. Schwab S., Soyka M., Niederecker M., Ackenheil M., Scherer J., and Wildenauer D.B. Allelic association of human D2 receptor DNA polymorphism ruled out in 45 alcoholics. Am. Journal of Hum. Genet. 49 (1991) 203
43. Singerman B., Stoltzman R., Robins L., Helzer J., and Croughan J.L. Diagnostic concordance between DSM-III, Feighner, and RDC. J. Clin. Psychiatry 42 (1981) 422-426
44. Vanderbergh D.J., Persico A.M., Hawkins A.L., Griffin C.A., Li X., Jabs E.W., and Uhl G.R. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 14 (1992) 1104-1106
45. Walter H., Ramskogler K., Semler B., Lesch O.M., and Platz W. Dopamine and alcohol relapse: D1 and D2 antagonists increase relapse rates in animal studies and in clinical trials. J. Biomed. Sci. 8 (2001) 83-88
46. Yang H., Chang C., Lin C., Chen C., Lin C., and Fann C. A genome-wide scanning and fine mapping study of COGA data. BMC Genet. 6 Suppl. 1 (2005) 30 (Epub ahead of print)