Miniaturization and validation of the Ellman's reaction based acetylcholinesterase inhibitory assay into 384-well plate format and screening of a chemical library

Combinatorial Chemistry and High Throughput Screening

Volumn 13, Issue 3, 2010, Pages 278-284

  Järvinen, Päivi P ^a,b   Fallarero, Adyary ^b   Gupta, Shikhar ^c   Mohan, Gobi C ^c   Hatakka, Annele I ^a   Vuorela, Pia M ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Ellman's method; High throughput screening; Inhibition; Miniaturization

Indexed keywords

ACETAMIDE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; N [3 (3,5 DIMETHYL 1 PIPERIDINYL)PROPYL] 5 ETHYL 2 METHYL 8 OXO THIENO [2',3' 4,5] PYRROLO[1,2 D] [1,2,4] TRIAZINE 7(8H) ACETAMID; PHYSOSTIGMINE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL REACTION KINETICS; DRUG STRUCTURE; ELECTRONICS; HIGH THROUGHPUT SCREENING; IC 50; PRACTICE GUIDELINE; PRIORITY JOURNAL; VALIDATION PROCESS;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; ELECTROPHORUS; HIGH-THROUGHPUT SCREENING ASSAYS; HORSES; INHIBITORY CONCENTRATION 50; MINIATURIZATION; SMALL MOLECULE LIBRARIES;

EID: 77949807477     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620710790980559     Document Type: Article

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