Molecular Anatomy of 2009 Influenza virus A (H1N1)

Archives of Medical Research

Volumn 40, Issue 8, 2009, Pages 643-654

  Arias, Carlos F ^a   Escalera Zamudio, Marina ^a   de los Dolores Soto Del Río, María ^a   Georgina Cobián Güemes, Ana ^a   Isa, Pavel ^a   López, Susana ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

Biology; Influenza; Pandemics; Pathogenesis; Virulence

Indexed keywords

AMANTADINE; ANTIVIRUS AGENT; CS 8958; FAVIPIRAVIR; INFLUENZA VIRUS HEMAGGLUTININ; NONSTRUCTURAL PROTEIN 1; OSELTAMIVIR; PERAMIVIR; RIMANTADINE; UNCLASSIFIED DRUG; VIRUS SIALIDASE; ZANAMIVIR;

AMINO ACID SUBSTITUTION; ANTIGENIC VARIATION; ANTIVIRAL RESISTANCE; CLINICAL TRIAL; GENETIC REASSORTMENT; HUMAN; IMMUNE RESPONSE; INFLUENZA; INFLUENZA VIRUS A H1N1; LOW TEMPERATURE; MIXED INFECTION; MOLECULAR PHYLOGENY; NONHUMAN; PANDEMIC; REVIEW; VIRUS ENTRY; VIRUS GENOME; VIRUS MORPHOLOGY; VIRUS PARTICLE; VIRUS PATHOGENESIS; VIRUS RECOMBINATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSMISSION; VIRUS VIRULENCE; ZOONOSIS;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; EVOLUTION, MOLECULAR; GALACTOSE; GENES, VIRAL; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; NEURAMINIDASE; PHYLOGENY; RECEPTORS, VIRUS; SIALIC ACIDS; VIRAL PROTEINS; VIRAL TROPISM; VIRUS REPLICATION;

EID: 77949720263     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2009.10.007     Document Type: Review

References (83)

1. Strauss J., Strauss E. Minus-strand RNA viruses. Viruses and Human Disease 2008, Elsevier, Oxford, UK, pp. 137-175. 2nd ed.
2. Wright P., Neumann G., Kawaoka Y. Orthomyxoviruses. Fields Virology 2006, 1691-1740. Lippincott Williams & Wilkins, Philadelphia. 5th ed. D. Knipe, P. Howley (Eds.).
3. Fouchier R.A., Munster V., Wallensten A., et al. Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J Virol 2005, 79:2814-2822.
4. Webster R.G., Bean W.J., Gorman O.T., et al. Evolution and ecology of influenza A viruses. Microbiol Rev 1992, 56:152-179.
5. Bouvier N.M., Palese P. The biology of influenza viruses. Vaccine 2008, 26(Suppl 4):D49-D53.
6. Palese P., Shaw M. Orthomyxoviridae: the viruses and their replication. Fields Virology 2006, 1647-1689. Lippincott Williams &Wilkins, Philadelphia. 5th ed. D. Knipe, P. Howley (Eds.).
7. Both G.W., Siegman L.J., Bellamy A.R., et al. Coding assignment and nucleotide sequence of simian rotavirus SA11 gene segment 10: location of glycosylation sites suggests that the signal peptide is not cleaved. J Virol 1983, 48:335-339.
8. Drake J.W. Rates of spontaneous mutation among RNA viruses. Proc Natl Acad Sci USA 1993, 90:4171-4175.
9. Smith G.J., Bahl J., Vijaykrishna D., et al. Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci USA 2009, 106:11709-11712.
10. Suzuki Y., Nei M. Simulation study of the reliability and robustness of the statistical methods for detecting positive selection at single amino acid sites. Mol Biol Evol 2002, 19:1865-1869.
11. Scholtissek C., Rohde W., Von Hoyningen V., et al. On the origin of the human influenza virus subtypes H2N2 and H3N2. Virology 1978, 87:13-20.
12. Holmes E.C., Ghedin E., Miller N., et al. Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses. PLoS Biol 2005, 3:e300.
13. Orlich M., Gottwald H., Rott R. Nonhomologous recombination between the hemagglutinin gene and the nucleoprotein gene of an influenza virus. Virology 1994, 204:462-465.
14. Suarez D.L., Senne D.A., Banks J., et al. Recombination resulting in virulence shift in avian influenza outbreak, Chile. Emerg Infect Dis 2004, 10:693-699.
15. Boni M.F., Zhou Y., Taubenberger J.K., et al. Homologous recombination is very rare or absent in human influenza A virus. J Virol 2008, 82:4807-4811.
16. He C.Q., Xie Z.X., Han G.Z., et al. Homologous recombination as an evolutionary force in the avian influenza A virus. Mol Biol Evol 2009, 26:177-187.
17. Ma W., Lager K.M., Vincent A.L., et al. The Role of Swine in the Generation of Novel Influenza Viruses. Zoonoses Public Health 2009.
18. Pappas C., Aguilar P.V., Basler C.F., et al. Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus. Proc Natl Acad Sci USA 2008, 105:3064-3069.
19. Lycett S.J., Ward M.J., Lewis F.I., et al. Detection of mammalian virulence determinants in highly pathogenic avian influenza H5N1 viruses: multivariate analysis of published data. J Virol 2009, 83:9901-9910.
20. Itoh Y., Shinya K., Kiso M., et al. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 2009, 460:1021-1025.
21. Munster V.J., de Wit E., van den Brand J.M., et al. Pathogenesis and transmission of swine-origin 2009 A (H1N1) influenza virus in ferrets. Science 2009, 325:481-483.
22. Barnett J.M., Cadman A., Burrell F.M., et al. In vitro selection and characterisation of influenza B/Beijing/1/87 isolates with altered susceptibility to zanamivir. Virology 1999, 265:286-295.
23. Connor R.J., Kawaoka Y., Webster R.G., et al. Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates. Virology 1994, 205:17-23.
24. Naeve C.W., Hinshaw V.S., Webster R.G. Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus. J Virol 1984, 51:567-569.
25. Rogers G.N., Paulson J.C. Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology 1983, 127:361-373.
26. Glaser L., Stevens J., Zamarin D., et al. A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J Virol 2005, 79:11533-11536.
27. Stevens J., Blixt O., Glaser L., et al. Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities. J Mol Biol 2006, 355:1143-1155.
28. Tumpey T.M., Maines T.R., Van Hoeven N., et al. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 2007, 315:655-659.
29. Garten R.J., Davis C.T., Russell C.A., et al. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science 2009, 325:197-201.
30. Neumann G., Noda T., Kawaoka Y. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 2009, 459:931-939.
31. Stevens J., Corper A.L., Basler C.F., et al. Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. Science 2004, 303:1866-1870.
32. Stegmann T., White J.M., Helenius A. Intermediates in influenza induced membrane fusion. EMBO J 1990, 9:4231-4241.
33. Horimoto T., Nakayama K., Smeekens S.P., et al. Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses. J Virol 1994, 68:6074-6078.
34. Zamarin D., Garcia-Sastre A., Xiao X., et al. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog 2005, 1:e4.
35. McAuley J.L., Hornung F., Boyd K.L., et al. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2007, 2:240-249.
36. Conenello G.M., Zamarin D., Perrone L.A., et al. A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence. PLoS Pathog 2007, 3:1414-1421.
37. Gabriel G., Dauber B., Wolff T., et al. The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci USA 2005, 102:18590-18595.
38. Steel J., Lowen A.C., Mubareka S., et al. Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog 2009, 5. e1000252.
39. Hatta M., Hatta Y., Kim J.H., et al. Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathog 2007, 3:1374-1379.
40. Massin P., van der Werf S., Naffakh N. Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. J Virol 2001, 75:5398-5404.
41. Van Hoeven N., Pappas C., Belser J.A., et al. Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proc Natl Acad Sci USA 2009, 106:3366-3371.
42. Gabriel G., Herwig A., Klenk H.D. Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus. PLoS Pathog 2008, 4:e11.
43. Seo S.H., Hoffmann E., Webster R.G. Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nat Med 2002, 8:950-954.
44. Jackson D., Hossain M.J., Hickman D., et al. A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci USA 2008, 105:4381-4386.
45. Jiao P., Tian G., Li Y., et al. A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J Virol 2008, 82:1146-1154.
46. Li Z., Jiang Y., Jiao P., et al. The NS1 gene contributes to the virulence of H5N1 avian influenza viruses. J Virol 2006, 80:11115-11123.
47. Varghese J.N., Laver W.G., Colman P.M. Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution. Nature 1983, 303:35-40.
48. Deyde V.M., Xu X., Bright R.A., et al. Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide. J Infect Dis 2007, 196:249-257.
49. Schmidtke M., Zell R., Bauer K., et al. Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001. Intervirology 2006, 49:286-293.
50. Abed Y., Nehme B., Baz M., et al. Activity of the neuraminidase inhibitor A-315675 against oseltamivir-resistant influenza neuraminidases of N1 and N2 subtypes. Antiviral Res 2008, 77:163-166.
51. Baz M., Abed Y., Boivin G. Characterization of drug-resistant recombinant influenza A/H1N1 viruses selected in vitro with peramivir and zanamivir. Antiviral Res 2007, 74:159-162.
52. Gubareva L.V., Bethell R., Hart G.J., et al. Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en. J Virol 1996, 70:1818-1827.
53. Gubareva L.V., Kaiser L., Hayden F.G. Influenza virus neuraminidase inhibitors. Lancet 2000, 355:827-835.
54. Colman P.M. New antivirals and drug resistance. Annu Rev Biochem 2009, 78:95-118.
55. Dharan N.J., Gubareva L.V., Meyer J.J., et al. Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States. JAMA 2009, 301:1034-1041.
56. Poland G.A. Valuing influenza vaccine: medical, economic, and social benefits. Clin Infect Dis 2009, 48:299-301.
57. Furuta Y., Takahashi K., Fukuda Y., et al. In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob Agents Chemother 2002, 46:977-981.
58. Babu Y.S., Chand P., Bantia S., et al. BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. J Med Chem 2000, 43:3482-3486.
59. Yamashita M., Tomozawa T., Kakuta M., et al. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob Agents Chemother 2009, 53:186-192.
60. Sui J., Hwang W.C., Perez S., et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat Struct Mol Biol 2009, 16:265-273.
61. Shope R. The etiology of swine influenza. Science 1931, 73. 215-215.
62. Webby R.J., Swenson S.L., Krauss S.L., et al. Evolution of swine H3N2 influenza viruses in the United States. J Virol 2000, 74:8243-8251.
63. Vincent A.L., Lager K.M., Ma W., et al. Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States. Vet Microbiol 2006, 118:212-222.
64. Pensaert M., Ottis K., Vandeputte J., et al. Evidence for the natural transmission of influenza A virus from wild ducts to swine and its potential importance for man. Bull World Health Organ 1981, 59:75-78.
65. Brown I.H. The epidemiology and evolution of influenza viruses in pigs. Vet Microbiol 2000, 74:29-46.
66. Jung K., Song D.S. Evidence of the co-circulation of influenza H1N1, H1N2 and H3N2 viruses in the pig population of Korea. Vet Rec 2007, 161:104-105.
67. Trifonov V., Khiabanian H., Rabadan R. Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus. N Engl J Med 2009, 361:115-119.
68. Fraser C., Donnelly C.A., Cauchemez S., et al. Pandemic potential of a strain of influenza A (H1N1): early findings. Science 2009, 324:1557-1561.
69. Kawaoka Y., Webster R.G. Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells. Proc Natl Acad Sci USA 1988, 85:324-328.
70. Subbarao E.K., Kawaoka Y., Murphy B.R. Rescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation. J Virol 1993, 67:7223-7228.
71. Gabriel G., Abram M., Keiner B., et al. Differential polymerase activity in avian and mammalian cells determines host range of influenza virus. J Virol 2007, 81:9601-9604.
72. Chen W., Calvo P.A., Malide D., et al. A novel influenza A virus mitochondrial protein that induces cell death. Nat Med 2001, 7:1306-1312.
73. Katz J.M., Lu X., Tumpey T.M., et al. Molecular correlates of influenza A H5N1 virus pathogenesis in mice. J Virol 2000, 74:10807-10810.
74. Subbarao K., Shaw M.W. Molecular aspects of avian influenza (H5N1) viruses isolated from humans. Rev Med Virol 2000, 10:337-348.
75. Gubareva L.V., Robinson M.J., Bethell R.C., et al. Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en. J Virol 1997, 71:3385-3390.
76. Yamada S., Suzuki Y., Suzuki T., et al. Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 2006, 444:378-382.
77. Hatta M., Gao P., Halfmann P., et al. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 2001, 293:1840-1842.
78. Wu W.L., Chen Y., Wang P., et al. Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. J Virol 2008, 82:1798-1807.
79. Gubareva L.V. Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors. Virus Res 2004, 103:199-203.
80. Deyde V.M., Nguyen T., Bright R.A., et al. Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing method. Antimicrob Agents Chemother 2009, 53:1039-1047.
81. Seo S.H., Hoffmann E., Webster R.G. The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses. Virus Res 2004, 103:107-113.
82. Solorzano A., Webby R.J., Lager K.M., et al. Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J Virol 2005, 79:7535-7543.
83. Min J.Y., Li S., Sen G.C., et al. A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis. Virology 2007, 363:236-243.