SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition

Oncogene

Volumn 29, Issue 11, 2010, Pages 1702-1716

  Kim, J A ^a   Lee, J ^a   Margolis, R L ^a,b   Fotedar, R ^a,b  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Cdk1 activation; Endoreplication; G2 M progression; JNK; Polyploidy; SP600125

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; AURORA A KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; DNA; POLO LIKE KINASE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA REPLICATION; ENDOREPLICATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; MITOSIS; POLYPLOIDY; PRIORITY JOURNAL;

ANTHRACENES; BLOTTING, WESTERN; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN B; CYCLIN-DEPENDENT KINASE 2; DNA REPLICATION; ENZYME ACTIVATION; FLOW CYTOMETRY; G2 PHASE; HCT116 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOSIS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77949659740     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.464     Document Type: Article

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