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Volumn 65 A, Issue 3, 2010, Pages 225-235

Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians

Author keywords

Cytokine; Inflammation; Late life survival

Indexed keywords

CYTOKINE;

EID: 77949501780     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glp210     Document Type: Article
Times cited : (16)

References (83)
  • 1
    • 0032496353 scopus 로고    scopus 로고
    • Biodemographic trajectories of longevity
    • Vaupel JW, Carey JR, Christensen K, et al. Biodemographic trajectories of longevity. Science. 1998;280:855-860.
    • (1998) Science , vol.280 , pp. 855-860
    • Vaupel, J.W.1    Carey, J.R.2    Christensen, K.3
  • 2
    • 0141923680 scopus 로고    scopus 로고
    • Predictors of mortality in 2,249 nonagenarians\the Danish 1905-Cohort Survey
    • Nybo H, Petersen HC, Gaist D, et al. Predictors of mortality in 2,249 nonagenarians\the Danish 1905-Cohort Survey. J Am Geriatr Soc. 2003;51:1365-1373.
    • (2003) J Am Geriatr Soc , vol.51 , pp. 1365-1373
    • Nybo, H.1    Petersen, H.C.2    Gaist, D.3
  • 4
    • 33646898766 scopus 로고    scopus 로고
    • Prediction of mortality risk in the elderly
    • Störk S, Feelders RA, Van den Beld AW, et al. Prediction of mortality risk in the elderly. Am J Med. 2006;119:519-525.
    • (2006) Am J Med , vol.119 , pp. 519-525
    • Störk, S.1    Feelders, R.A.2    Van Den Beld, A.W.3
  • 5
    • 0033134682 scopus 로고    scopus 로고
    • Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
    • Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106:506-512.
    • (1999) Am J Med , vol.106 , pp. 506-512
    • Harris, T.B.1    Ferrucci, L.2    Tracy, R.P.3
  • 7
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685-1695.
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 8
    • 0036237810 scopus 로고    scopus 로고
    • Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study
    • Visser M, Pahor M, Taaffe DR, et al. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2002;57:M326-M332.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57
    • Visser, M.1    Pahor, M.2    Taaffe, D.R.3
  • 9
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 10
    • 35948933394 scopus 로고    scopus 로고
    • Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
    • Ray S, Britschgi M, Herbert C, et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med. 2007;13:1359-1362.
    • (2007) Nat Med , vol.13 , pp. 1359-1362
    • Ray, S.1    Britschgi, M.2    Herbert, C.3
  • 11
    • 0037180778 scopus 로고    scopus 로고
    • The inflammatory reflex
    • Tracey KJ. The inflammatory reflex. Nature. 2002;420:853-859.
    • (2002) Nature , vol.420 , pp. 853-859
    • Tracey, K.J.1
  • 12
    • 5444239286 scopus 로고    scopus 로고
    • Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming
    • Van Den Biggelaar AH, De Craen AJ, Gussekloo J, et al. Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming. FASEB J. 2004;18:1022-1024.
    • (2004) FASEB J , vol.18 , pp. 1022-1024
    • Van Den Biggelaar, A.H.1    De Craen, A.J.2    Gussekloo, J.3
  • 14
    • 4544322522 scopus 로고    scopus 로고
    • Inflammatory exposure and historical changes in human life-spans
    • Finch CE, Crimmins EM. Inflammatory exposure and historical changes in human life-spans. Science. 2004;305:1736-1739.
    • (2004) Science , vol.305 , pp. 1736-1739
    • Finch, C.E.1    Crimmins, E.M.2
  • 16
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
    • Wiss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med. 2006;12:1005-1015.
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wiss-Coray, T.1
  • 17
    • 0037721389 scopus 로고    scopus 로고
    • The-308 G/A tumor necrosis factor-alpha gene dimorphism: A risk factor for unstable angina
    • Bernard V, Pillois X, Dubus I, et al. The-308 G/A tumor necrosis factor-alpha gene dimorphism: a risk factor for unstable angina. Clin Chem Lab Med. 2003;41:511-516.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 511-516
    • Bernard, V.1    Pillois, X.2    Dubus, I.3
  • 18
    • 35648965192 scopus 로고    scopus 로고
    • Interleukin-6 174G/C polymorphism and ischemic stroke: A systematic review
    • Tso AR, Merino JG, Warach S. Interleukin-6 174G/C polymorphism and ischemic stroke: a systematic review. Stroke. 2007;38:3070-3075.
    • (2007) Stroke , vol.38 , pp. 3070-3075
    • Tso, A.R.1    Merino, J.G.2    Warach, S.3
  • 19
    • 0036616916 scopus 로고    scopus 로고
    • Association of the tumour necrosis factor alpha-308G/A polymorphism with the risk of diabetes in an elderly population-based cohort
    • Heijmans BT, Westendorp RG, Droog S, Kluft C, Knook DL, Slagboom PE. Association of the tumour necrosis factor alpha-308G/A polymorphism with the risk of diabetes in an elderly population-based cohort. Genes Immun. 2007;3:225-228.
    • (2007) Genes Immun , vol.3 , pp. 225-228
    • Heijmans, B.T.1    Westendorp, R.G.2    Droog, S.3    Kluft, C.4    Knook, D.L.5    Slagboom, P.E.6
  • 20
    • 53049093745 scopus 로고    scopus 로고
    • TNF promoter polymorphisms associated with muscle phenotypes in humans
    • Liu D, Metter EJ, Ferrucci L, Roth SM. TNF promoter polymorphisms associated with muscle phenotypes in humans. J Appl Physiol. 2008;105:859-867.
    • (2008) J Appl Physiol , vol.105 , pp. 859-867
    • Liu, D.1    Metter, E.J.2    Ferrucci, L.3    Roth, S.M.4
  • 21
    • 37549009962 scopus 로고    scopus 로고
    • Association between genetic variants of IL-1beta IL-6 and TNF-alpha cytokines and cognitive performance in the elderly general population of the MEMO-study
    • Baune BT, Ponath G, Rothermundt M, Riess O, Funke H, Berger K. Association between genetic variants of IL-1beta, IL-6 and TNF-alpha cytokines and cognitive performance in the elderly general population of the MEMO-study. Psychoneuroendocrinology. 2008;33:68-76.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 68-76
    • Baune, B.T.1    Ponath, G.2    Rothermundt, M.3    Riess, O.4    Funke, H.5    Berger, K.6
  • 22
    • 53849138674 scopus 로고    scopus 로고
    • Lack of association between TNF-alpha polymorphisms and Alzheimer's disease in an Italian cohort
    • Tedde A, Putignano AL, Nacmias B, Bagnoli S, Cellini E, Sorbi S. Lack of association between TNF-alpha polymorphisms and Alzheimer's disease in an Italian cohort. Neurosci Lett. 2008;446:139-142.
    • (2008) Neurosci Lett , vol.446 , pp. 139-142
    • Tedde, A.1    Putignano, A.L.2    Nacmias, B.3    Bagnoli, S.4    Cellini, E.5    Sorbi, S.6
  • 23
    • 0034849867 scopus 로고    scopus 로고
    • A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity
    • Bonafè M, Olivieri F, Cavallone L, et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol. 2001;31:2357-2361.
    • (2001) Eur J Immunol , vol.31 , pp. 2357-2361
    • Bonafè, M.1    Olivieri, F.2    Cavallone, L.3
  • 24
    • 0037374849 scopus 로고    scopus 로고
    • Inflammation, genetics, and longevity: Further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha-308 promoter SNP
    • Lio D, Scola L, Crivello A, et al. Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha-308 promoter SNP. J Med Genet. 2003;40:296-299.
    • (2003) J Med Genet , vol.40 , pp. 296-299
    • Lio, D.1    Scola, L.2    Crivello, A.3
  • 25
    • 47049121588 scopus 로고    scopus 로고
    • A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism
    • Cardelli M, Cavallone L, Marchegiani F, et al. A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism. J Gerontol A Biol Sci Med Sci. 2008;63:454-460.
    • (2008) J Gerontol A Biol Sci Med Sci , vol.63 , pp. 454-460
    • Cardelli, M.1    Cavallone, L.2    Marchegiani, F.3
  • 26
    • 57749202485 scopus 로고    scopus 로고
    • Effect of interleukin-6 polymorphisms on human longevity: A systematic review and meta-analysis
    • Di Bona D, Vasto S, Capurso C, et al. Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis. Ageing Res Rev. 2009;8:36-42.
    • (2009) Ageing Res Rev , vol.8 , pp. 36-42
    • Di Bona, D.1    Vasto, S.2    Capurso, C.3
  • 27
    • 5444225275 scopus 로고    scopus 로고
    • Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study
    • Van den Biggelaar AH, Huizinga TW, de Craen AJ, et al. Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study. Exp Gerontol. 2004;39:1407-1414.
    • (2004) Exp Gerontol , vol.39 , pp. 1407-1414
    • Van Den Biggelaar, A.H.1    Huizinga, T.W.2    De Craen, A.J.3
  • 30
    • 0035319112 scopus 로고    scopus 로고
    • Cytokine gene polymorphism in human disease: On-line databases, supplement 1
    • Bidwell J, Keen L, Gallagher G, et al. Cytokine gene polymorphism in human disease: on-line databases, supplement 1. Genes Immun. 2001;2:61-70.
    • (2001) Genes Immun , vol.2 , pp. 61-70
    • Bidwell, J.1    Keen, L.2    Gallagher, G.3
  • 31
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
    • Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998;102:1369-1376.
    • (1998) J Clin Invest , vol.102 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffery, R.3
  • 32
    • 0033031984 scopus 로고    scopus 로고
    • Polymorphic haplotypes of the interleukin-10 5′ Flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis
    • Crawley E, Kay R, Sillibourne J, Patel P, Hutchinson I, Woo P. Polymorphic haplotypes of the interleukin-10 5′ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum. 1999;42:1101-1108.
    • (1999) Arthritis Rheum , vol.42 , pp. 1101-1108
    • Crawley, E.1    Kay, R.2    Sillibourne, J.3    Patel, P.4    Hutchinson, I.5    Woo, P.6
  • 33
    • 3843150366 scopus 로고    scopus 로고
    • The tumor necrosis factor alpha-308GG>A polymorphism is associated with dementia in the oldest old
    • Bruunsgaard H, Benfield TL, Andersen-Ranberg K, et al. The tumor necrosis factor alpha-308GG>A polymorphism is associated with dementia in the oldest old. J Am Geriatr Soc. 2004;52:1361-1366.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 1361-1366
    • Bruunsgaard, H.1    Benfield, T.L.2    Andersen-Ranberg, K.3
  • 34
    • 34047135047 scopus 로고    scopus 로고
    • An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people
    • Frayling TM, Rafiq S, Murray A, et al. An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol A Biol Sci Med Sci. 2007;62:73-78.
    • (2007) J Gerontol A Biol Sci Med Sci , vol.62 , pp. 73-78
    • Frayling, T.M.1    Rafiq, S.2    Murray, A.3
  • 35
    • 0033024330 scopus 로고    scopus 로고
    • Serum IL-6 level and the development of disability in older persons
    • Ferrucci L, Harris TB, Guralnik JM, et al. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc. 1999;47:639-646.
    • (1999) J Am Geriatr Soc , vol.47 , pp. 639-646
    • Ferrucci, L.1    Harris, T.B.2    Guralnik, J.M.3
  • 36
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    • Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-270.
    • (2000) Annu Rev Med , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 38
    • 43249118045 scopus 로고    scopus 로고
    • Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review
    • Danesh J, Kaptoge S, Mann AG, et al. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med. 2008;5:e78.
    • (2008) PLoS Med , vol.5
    • Danesh, J.1    Kaptoge, S.2    Mann, A.G.3
  • 39
    • 0035187606 scopus 로고    scopus 로고
    • The Danish 1905 cohort: A genetic-epidemiological nationwide survey
    • Nybo H, Gaist D, Jeune B, et al. The Danish 1905 cohort: a genetic-epidemiological nationwide survey. J Aging Health. 2001;13:32-46.
    • (2001) J Aging Health , vol.13 , pp. 32-46
    • Nybo, H.1    Gaist, D.2    Jeune, B.3
  • 40
    • 33751395235 scopus 로고    scopus 로고
    • The danish civil registration system. A cohort of eight million persons
    • Pedersen CB, Gotzsche H, Moller JO, Mortensen PB. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull. 2006;53:441-449.
    • (2006) Dan Med Bull , vol.53 , pp. 441-449
    • Pedersen, C.B.1    Gotzsche, H.2    Moller, J.O.3    Mortensen, P.B.4
  • 42
    • 0016823810 scopus 로고
    • "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 43
    • 0034988718 scopus 로고    scopus 로고
    • The heritability of cognitive functioning in very old adults: Evidence from Danish twins aged 75 years and older
    • McGue M, Christensen K. The heritability of cognitive functioning in very old adults: evidence from Danish twins aged 75 years and older. Psychol Aging. 2001;16:272-280.
    • (2001) Psychol Aging , vol.16 , pp. 272-280
    • McGue, M.1    Christensen, K.2
  • 45
    • 33746631686 scopus 로고    scopus 로고
    • Handgrip strength among nonagenarians and centenarians in three European regions
    • Jeune B, Skytthe A, Cournil A, et al. Handgrip strength among nonagenarians and centenarians in three European regions. J Gerontol A Biol Sci Med Sci. 2006;61:707-712.
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 707-712
    • Jeune, B.1    Skytthe, A.2    Cournil, A.3
  • 46
    • 0027151876 scopus 로고
    • Highly informative typing of the human TNF locus using six adjacent polymorphic markers
    • Udalova IA, Nedospasov SA, Webb GC, Chaplin DD, Turetskaya RL. Highly informative typing of the human TNF locus using six adjacent polymorphic markers. Genomics. 1993;16:180-186.
    • (1993) Genomics , vol.16 , pp. 180-186
    • Udalova, I.A.1    Nedospasov, S.A.2    Webb, G.C.3    Chaplin, D.D.4    Turetskaya, R.L.5
  • 47
    • 0034254552 scopus 로고    scopus 로고
    • TNF-alpha gene polymorphism: Clinical and biological implications
    • Hajeer AH, Hutchinson IV. TNF-alpha gene polymorphism: clinical and biological implications. Microsc Res Tech. 2000;50:216-228.
    • (2000) Microsc Res Tech , vol.50 , pp. 216-228
    • Hajeer, A.H.1    Hutchinson, I.V.2
  • 48
    • 0027397580 scopus 로고
    • Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: A possible link to insulin-dependent diabetes mellitus
    • Pociot F, Briant L, Jongeneel CV, et al. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. Eur J Immunol. 1993;23:224-231.
    • (1993) Eur J Immunol , vol.23 , pp. 224-231
    • Pociot, F.1    Briant, L.2    Jongeneel, C.V.3
  • 49
    • 0030954180 scopus 로고    scopus 로고
    • Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation
    • Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. PNAS. 1997;94:3195-3199.
    • (1997) PNAS , vol.94 , pp. 3195-3199
    • Wilson, A.G.1    Symons, J.A.2    McDowell, T.L.3    McDevitt, H.O.4    Duff, G.W.5
  • 50
    • 0028366342 scopus 로고
    • A polymorphic variation in a putative regulation box of the TNFA promoter region
    • D'Alfonso S, Richiardi PM. A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics. 1994;39:150-154.
    • (1994) Immunogenetics , vol.39 , pp. 150-154
    • D'Alfonso, S.1    Richiardi, P.M.2
  • 51
    • 0040780540 scopus 로고    scopus 로고
    • Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation
    • Terry CF, Loukaci V, Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem. 2000;275:18138-18144.
    • (2000) J Biol Chem , vol.275 , pp. 18138-18144
    • Terry, C.F.1    Loukaci, V.2    Green, F.R.3
  • 52
    • 61349133510 scopus 로고    scopus 로고
    • Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
    • Huth C, Illig T, Herder C, et al. Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174G>C with circulating glucose levels, interleukin-6 levels, and body mass index. Ann Med. 2009;41:128-138.
    • (2009) Ann Med , vol.41 , pp. 128-138
    • Huth, C.1    Illig, T.2    Herder, C.3
  • 53
    • 33644820475 scopus 로고    scopus 로고
    • Interleukin 6-174 g/c promoter polymorphism and risk of coronary heart disease: Results from the Rotterdam study and a meta-analysis
    • Sie MP, Sayed-Tabatabaei FA, Oei HH, et al. Interleukin 6-174 g/c promoter polymorphism and risk of coronary heart disease: results from the Rotterdam study and a meta-analysis. Arterioscler Thromb Vasc Biol. 2006;26:212-217.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 212-217
    • Sie, M.P.1    Sayed-Tabatabaei, F.A.2    Oei, H.H.3
  • 55
    • 2342635096 scopus 로고    scopus 로고
    • Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma
    • Kurz T, Strauch K, Dietrich H, et al. Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma. J Allergy Clin Immunol. 2004;113:896-901.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 896-901
    • Kurz, T.1    Strauch, K.2    Dietrich, H.3
  • 57
    • 0035205687 scopus 로고    scopus 로고
    • Cloning and mutation analysis of the human IL-18 promoter: A possible role of polymorphisms in expression regulation
    • Giedraitis V, He B, Huang WX, Hillert J. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuroimmunol. 2001;112:146-152.
    • (2001) J Neuroimmunol , vol.112 , pp. 146-152
    • Giedraitis, V.1    He, B.2    Huang, W.X.3    Hillert, J.4
  • 58
    • 19944433955 scopus 로고    scopus 로고
    • Pro-and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: Interactions influence outcome
    • Zambon CF, Basso D, Navaglia F, et al. Pro-and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine. 2005;29:141-152.
    • (2005) Cytokine , vol.29 , pp. 141-152
    • Zambon, C.F.1    Basso, D.2    Navaglia, F.3
  • 59
    • 17144450947 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease
    • Culpan D, MacGowan SH, Ford JM, et al. Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease. Neurosci Lett. 2003;350:61-65.
    • (2003) Neurosci Lett , vol.350 , pp. 61-65
    • Culpan, D.1    MacGowan, S.H.2    Ford, J.M.3
  • 60
    • 0001882950 scopus 로고
    • On a matching problem arising in genetics
    • Levene H. On a matching problem arising in genetics. Ann Math Stat. 1949;20:91-94.
    • (1949) Ann Math Stat , vol.20 , pp. 91-94
    • Levene, H.1
  • 62
    • 0030131165 scopus 로고    scopus 로고
    • Testing for linkage disequilibrium in genotypic data using the expectation-maximization algorithm
    • Slatkin M, Excoffier L. Testing for linkage disequilibrium in genotypic data using the expectation-maximization algorithm. Heredity. 1996;76:377-383.
    • (1996) Heredity , vol.76 , pp. 377-383
    • Slatkin, M.1    Excoffier, L.2
  • 64
    • 85007110786 scopus 로고    scopus 로고
    • Arlequin ver. 3.0: An integrated software package for population genetics data analysis
    • Excoffier L, Laval G, Schneider S. Arlequin ver. 3.0: an integrated software package for population genetics data analysis. Evol Bioinform Online. 2005;1:47-50.
    • (2005) Evol Bioinform Online , vol.1 , pp. 47-50
    • Excoffier, L.1    Laval, G.2    Schneider, S.3
  • 65
    • 56549099067 scopus 로고    scopus 로고
    • Sex-specific genetic architecture of human disease
    • Ober C, Loisel DA, Gilad Y. Sex-specific genetic architecture of human disease. Nat Rev Genet. 2008;9:911-922.
    • (2008) Nat Rev Genet , vol.9 , pp. 911-922
    • Ober, C.1    Loisel, D.A.2    Gilad, Y.3
  • 66
    • 0034044042 scopus 로고    scopus 로고
    • Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE)
    • Franceschi C, Motta L, Valensin S, et al. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging. 2000;12:77-84.
    • (2000) Aging , vol.12 , pp. 77-84
    • Franceschi, C.1    Motta, L.2    Valensin, S.3
  • 67
    • 62649121840 scopus 로고    scopus 로고
    • Genetic priming of a proinflammatory profile predicts low IQ in octogenarians
    • Krabbe KS, Mortensen EL, Avlund K, et al. Genetic priming of a proinflammatory profile predicts low IQ in octogenarians. Neurobiol Aging. 2009;30:769-781.
    • (2009) Neurobiol Aging , vol.30 , pp. 769-781
    • Krabbe, K.S.1    Mortensen, E.L.2    Avlund, K.3
  • 68
    • 19244364722 scopus 로고    scopus 로고
    • Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis
    • Mulcahy B, Waldron-Lynch F, McDermott MF, et al. Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis. Am J Hum Genet. 1996;59:676-683.
    • (1996) Am J Hum Genet , vol.59 , pp. 676-683
    • Mulcahy, B.1    Waldron-Lynch, F.2    McDermott, M.F.3
  • 69
    • 0034792299 scopus 로고    scopus 로고
    • Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians
    • Wang XY, Hurme M, Jylhä M, Hervonen A. Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians. Mech Ageing Dev. 2001;123:29-38.
    • (2001) Mech Ageing Dev , vol.123 , pp. 29-38
    • Wang, X.Y.1    Hurme, M.2    Jylhä, M.3    Hervonen, A.4
  • 70
    • 0037398764 scopus 로고    scopus 로고
    • HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish
    • Ross OA, Curran MD, Rea IM, et al. HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish. Mech Ageing Dev. 2003;124:563-567.
    • (2003) Mech Ageing Dev , vol.124 , pp. 563-567
    • Ross, O.A.1    Curran, M.D.2    Rea, I.M.3
  • 71
    • 0034606268 scopus 로고    scopus 로고
    • Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: The NIMH Alzheimer Disease Genetics Initiative
    • Collins JS, Perry RT, Watson B, Jr. et al. Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. Am J Med Genet. 2000;96:823-830.
    • (2000) Am J Med Genet , vol.96 , pp. 823-830
    • Collins, J.S.1    Perry, R.T.2    Watson Jr., B.3
  • 72
    • 0037043033 scopus 로고    scopus 로고
    • Association between the TNFalpha-308 A/G polymorphism and the onset-age of Alzheimer disease
    • Alvarez V, Mata IF, Gonzalez P, et al. Association between the TNFalpha-308 A/G polymorphism and the onset-age of Alzheimer disease. Am J Med Genet. 2002;114:574-577.
    • (2002) Am J Med Genet , vol.114 , pp. 574-577
    • Alvarez, V.1    Mata, I.F.2    Gonzalez, P.3
  • 73
    • 22144465537 scopus 로고    scopus 로고
    • TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels
    • Laws SM, Perneczky R, Wagenpfeil S, et al. TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels. Hum Mutat. 2005;26:29-35.
    • (2005) Hum Mutat , vol.26 , pp. 29-35
    • Laws, S.M.1    Perneczky, R.2    Wagenpfeil, S.3
  • 74
    • 68149148867 scopus 로고    scopus 로고
    • Rejuvenation of the aging T cell compartment
    • Holland AM, van den Brink MR. Rejuvenation of the aging T cell compartment. Curr Opin Immunol. 2009;21:454-459.
    • (2009) Curr Opin Immunol , vol.21 , pp. 454-459
    • Holland, A.M.1    Van Den Brink, M.R.2
  • 75
    • 58249130474 scopus 로고    scopus 로고
    • Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease
    • Yu JT, Tan L, Song JH, et al. Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease. Brain Res. 2009;1253:169-175.
    • (2009) Brain Res , vol.1253 , pp. 169-175
    • Yu, J.T.1    Tan, L.2    Song, J.H.3
  • 76
    • 0037444005 scopus 로고    scopus 로고
    • Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms
    • Suárez A, Castro P, Alonso R, Mozo L, Gutiérrez C. Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms. Transplantation. 2003;75:711-717.
    • (2003) Transplantation , vol.75 , pp. 711-717
    • Suárez, A.1    Castro, P.2    Alonso, R.3    Mozo, L.4    Gutiérrez, C.5
  • 77
    • 33845803671 scopus 로고    scopus 로고
    • Sex and age specificity of susceptibility genes modulating survival at old age
    • Passarino G, Montesanto A, Dato S, et al. Sex and age specificity of susceptibility genes modulating survival at old age. Hum Hered. 2006;62:213-220.
    • (2006) Hum Hered , vol.62 , pp. 213-220
    • Passarino, G.1    Montesanto, A.2    Dato, S.3
  • 78
    • 37349019458 scopus 로고    scopus 로고
    • Gender, a significant factor in the cross talk between genes, environment, and health
    • Ordovas JM. Gender, a significant factor in the cross talk between genes, environment, and health. Gend Med, 2007;4(suppl B): S111-S122.
    • (2007) Gend Med , vol.4 , Issue.SUPPL. B
    • Ordovas, J.M.1
  • 79
    • 34447644805 scopus 로고    scopus 로고
    • Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients
    • Cederholm T, Persson M, Andersson P, et al. Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients. J Intern Med. 2007;262:215-223.
    • (2007) J Intern Med , vol.262 , pp. 215-223
    • Cederholm, T.1    Persson, M.2    Andersson, P.3
  • 80
    • 0035487313 scopus 로고    scopus 로고
    • Cytokines and acute neurodegeneration
    • Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci. 2001;2:734-744.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 734-744
    • Allan, S.M.1    Rothwell, N.J.2
  • 81
  • 83
    • 0032542897 scopus 로고    scopus 로고
    • What's wrong with Bonferroni adjustments?
    • Pernerger TV. What's wrong with Bonferroni adjustments? BMJ. 1998;316:1236-1238.
    • (1998) BMJ , vol.316 , pp. 1236-1238
    • Pernerger, T.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.