Moscatilin induces apoptosis in human colorectal cancer cells: A crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage

Clinical Cancer Research

Volumn 14, Issue 13, 2008, Pages 4250-4258

  Chen, Tzu Hsuan ^a   Pan, Shiow Lin ^a   Guh, Jih Hwa ^a   Liao, Cho Hwa ^a   Huang, Der Yi ^a   Chen, Chien Chih ^b   Teng, Che Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; HISTONE H2AX; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MOSCATILIN; PACLITAXEL; PROTEIN BCL 2; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; TUBULIN; UNCLASSIFIED DRUG; VINCRISTINE; BENZYL DERIVATIVE; DENDROPHENOL;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN HCT116; COLORECTAL CANCER; COMET ASSAY; DNA DAMAGE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFICACY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE ASSEMBLY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION; WESTERN BLOTTING; XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CELL SEPARATION; CHEMISTRY; COLORECTAL TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BENZYL COMPOUNDS; CELL LINE, TUMOR; CELL SEPARATION; COLORECTAL NEOPLASMS; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; NEOPLASM TRANSPLANTATION; TUBULIN;

EID: 48249090478     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-4578     Document Type: Article

References (42)

1. Hibi M, Lin A, SmealT, Minden A, Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993;7:2135-48.
2. Liu J, Lin A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res 2005;15:36-42.
3. Cho SG, Choi EJ. Apoptotic signaling pathways: caspases and stress-activated protein kinases. J Biochem Mol Biol 2002;35:24-7.
4. Hochedlinger K. Wagner EF, Sabapathy K. Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. Oncogene 2002;21:2441-5.
5. Behrens A, Sibilia M, Wagner EF. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 1999; 21:326-9.
6. Tournier C, Hess P, Yang DD, et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000;288:870-4.
7. Lei K, Nimnual A, Zong WX, et al. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH (2) -terminal kinase. Mol Cell Biol 2002;22:4929-42.
8. Graves JD, Gotoh Y, Draves KE, et al. Caspasemediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J 1998;17: 2224-34.
9. Ichijo H, Nishida E, lrie K, et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 1997;275: 90-4.
10. MacFarlane M, Cohen GM, Dickens M. JNK (c-Jun N-terminal kinase) and p38 activation in receptormediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation. Biochem J 2000;348 Pt 1:93-101.
11. 2-terminal kinase and p38 kinase in calphostin C- induced apoptosis requires caspase-3-like proteases but is dispensable for cell death. J Biol Chem 1999; 274:5310-7.
12. Manfredi JJ, Parness J, Horwitz SB. Taxol binds to cellular microtubules. J Cell Biol 1982;94:688-96.
13. Rowinsky EK. The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu Rev Med 1997;48:353-74.
14. Hadfield JA, Ducki S, Hirst N, McGown AT. Tubulin and microtubules as targets for anticancer drugs. Prog Cell Cycle Res 2003;5:309-25.
15. Majumder PL, Sen RC. Moscatilin, a bibenzyl derivative from the orchid Dendrobrium moscatum. Phytochemistry 1987;26:2121-5.
16. Ho CK, Chen CC. Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent. Cancer Invest 2003;21:729-36.
17. Chen CC, Wu LG, Ko FN, Teng CM. Antiplatelet aggregation principles of Dendrobrium loddigesii. J Nat Prod 1994;57:1271-4.
18. Miyazawa M, Shimamura H, Nakamura S, Sugiura W, Kosaka H, Kameoka H. Moscatilin from Dendrobrium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. J Agric Food Chem 1999;47:2163-7.
19. Chen YC, Lu PH, Pan SL, et al. Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways. Biochem Pharmacol 2007;74:10-9.
20. 2 checkpoint. Oncogene 2002;21:8089-104.
21. 2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. Oncol Rep 2007;17:597-603.
22. Lu PH, Kung FL, Kuo SC, Chueh SC, Guh JH. Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. Naunyn Schmiedebergs Arch Pharmacol 2006;374:223-33.
23. RoosWP, Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol Med 2006;12:440-50.
24. Huang X, Traganos F, Darzynkiewicz Z. DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis. Cell Cycle 2003;2:614-9.
25. Wils P, Phung-Ba V, Warnery A, et al. Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem Pharmacol 1994;48:1528-30.
26. Metzinger DS, Taylor DD, Gercel-Taylor C. Induction of p53 and drug resistance following treatment with cisplatin or paclitaxel in ovarian cancer cell lines. Cancer Lett 2006;236:302-8.
27. Wang LG, Liu XM, KreisW, Budman DR. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol 1999;44:355-61.
28. Ling YH, Tornos C, Perez-Soler R. Phosphorylation of bcl-2 is a marker of M phase events and not a determinant of apoptosis. J Biol Chem 1998;273: 18984-91.
29. Taverna P, Rendahl K, Jekic-McMulen D, et al. Tezacitabine enhances the DNA-directed effects of fluoropyrimidines in human colon cancer cells and tumor xenografts. Biochem Pharmacol 2007;73:44-55.
30. Boccarelli A, Giordano D, Natile G, Coluccia M. Differential processing of antitumour-active and antitumour-inactive trans platinum compounds by SKOV-3 ovarian cancer cells. Biochem Pharmacol 2006;72: 280-92.
31. Montecucco A, Biamonti G. Cellular response to etoposide treatment. Cancer Lett 2007;252:9-18.
32. Efeyan A, Serrano M. p53: guardian of the genome and policeman of the oncogenes. Cell Cycle 2007;6: 1006-10.
33. Aris SM, Gewirtz DA, Ryan JJ. Knott KM, Farrell NP. Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes. Biochem Pharmacol 2007;73:1749-57.
34. Mohamad N, Gutierrez A, Nunez M, et al. Mitochondrial apoptotic pathways. Biocell 2005;29:149-61.
35. Shiah HS, Lee WS, Juang SH, et al. Mitochondriamediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036. Biochem Pharmacol 2007;73:610-9.
36. IpYT, Davis RJ. Signal transduction by the c-Jun N- terminal kinase (JNK)-from inflammation to development. Curr Opin Cell Biol 1998;10:205-19.
37. Potapova O, Gorospe M, Bost F, et al. c-Jun N- terminal kinase is essential for growth of human T98G glioblastoma cells. J Biol Chem 2000;275: 24767-75.
38. Bost F, McKay R, Bost M, Potapova O, Dean NM, Mercola D. The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol Cell Biol 1999;19:1938-49.
39. Sanchez-Perez I, Murguia JR, Perona R. Cisplatin induces a persistent activation of JNK that is related to cell death. Oncogene 1998;16:533-40.
40. Yang Y, Zhu X, Chen Y, Wang X, Chen R. p38 and JNK MAPK, but not ERK1/2 MAPK, play important role in colchicine-induced cortical neurons apoptosis. Eur J Pharmacol 2007;576:26-33.
41. Yang DD, Kuan CY, Whitmarsh AJ, et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997;389: 865-70.
42. Berglund CM, Radesater AC, Persson MA, Budd Haeberlein SL. UV-induced apoptosis in SH-SY5Y cells: contribution to apoptosis by JNK signaling and cytochrome c. J Neurosci Res 2004;78:580-9