KILLER/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death

Advances in Experimental Medicine and Biology

Volumn 465, Issue , 2000, Pages 143-151

  Wu, G S ^a   Kim, K ^a   El Deiry, W S ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DNA; FAS LIGAND; PROTEIN P21; PROTEIN P53; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; CELL CYCLE; DNA DAMAGE; ENZYME ACTIVATION; GENE INDUCTION; GENE THERAPY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CASPASES; DNA DAMAGE; ENZYME ACTIVATION; GENE THERAPY; HUMANS; LIGANDS; LINKAGE (GENETICS); NEOPLASMS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034482740     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (53)

1. Death receptors: Signaling and modulation
2. Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis
3. Self-association of the "death-domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects
4. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
5. Requirement for p53 and p21 to sustain G2 arrest after DNA damage
6. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway
7. FADD, a novel death domaincontaining protein, interacts with the death domain of Fas and initiates apoptosis
8. Thymocyte apoptosis induced by p53-dependent and independent pathways
9. The p53 pathway and cancer therapy
10. Cell death: TRAIL and its receptors
11. The TRAIL of death
12. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
13. The TNF receptor 1-associated protein TRADD signals cell death and NF activation
14. For p53, there's more than one way to kill a cell
15. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
16. On the TRAIL from p53 to apoptosis?
17. Apoptosis: A Basic Biological Phenomenon with Wide-Ranging Implications in Tissue Kinetics
18. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
19. p53, the cellular gatekeeper for growth and division
20. Identification and molecular cloning of two novel receptors for cytotoxic ligand TRAIL
21. Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA
22. A novel receptor for Apo2L/TRAIL contains a truncated death domain
23. Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apopiosis
24. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
25. A breakpoint map of recurrent chromosomal rearrangements in human neoplasia
26. Tumor suppressor p53 is a regulator of bc12 and bax gene expression in vitro and in vivo
27. Tumor suppressor p53 is a direct transcriptional activator of human bax gene
28. Apoptosis by death factor
29. Lethal effect of the anti-Fas antibody in mice
30. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APOexpression
31. Rare loss-of-function mutation of a death receptor gene in head and neck cancer
32. The receptor for the cytotoxic ligand TRAIL
33. An antagonist decoy receptor and a death domaincontaining receptor for TRAIL
34. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling
35. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
36. A model for p53-induced apoptosis
37. APO2 ligand: A novel lethal weapon against malignant glioma?
38. Characterization of two receptors for TRAIL
39. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-KB
40. TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signals from TRAIL
41. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
42. Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells
43. TNF-relating apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells
44. TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL
45. Identification and characterization of a new member of the TNF family that induces apoptosis
46. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
47. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
48. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
49. Transducing signals of life and death