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Volumn 53, Issue 2, 2010, Pages 183-189

Structural immunology of costimualtory and coinhibitory molecules

Author keywords

Costimulatory molecules; Immunotherapy; Molecular structure; T cells

Indexed keywords

CHEMICAL STRUCTURE; HUMAN; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 77949292371     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-010-0043-2     Document Type: Review
Times cited : (9)

References (43)
  • 1
    • 0027982995 scopus 로고
    • Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity
    • Chen L, McGowan P, Ashe S, et al. Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity. J Exp Med, 1994, 179: 523-532.
    • (1994) J Exp Med , vol.179 , pp. 523-532
    • Chen, L.1    McGowan, P.2    Ashe, S.3
  • 4
    • 0026537347 scopus 로고
    • CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
    • Harding F A, McArthur J G, Gross J A, et al. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature, 1992, 356: 607-609.
    • (1992) Nature , vol.356 , pp. 607-609
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3
  • 5
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol, 2004, 4: 336-347.
    • (2004) Nat Rev Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 6
    • 0036214017 scopus 로고    scopus 로고
    • The B7 family of ligands and its receptors: New pathways for costimulation and inhibition of immune responses
    • Carreno B M, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol, 2002, 20: 29-53.
    • (2002) Annu Rev Immunol , vol.20 , pp. 29-53
    • Carreno, B.M.1    Collins, M.2
  • 7
    • 0035967157 scopus 로고    scopus 로고
    • Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
    • Schwartz J C, Zhang X, Fedorov A A, et al. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature, 2001, 410: 604-608.
    • (2001) Nature , vol.410 , pp. 604-608
    • Schwartz, J.C.1    Zhang, X.2    Fedorov, A.A.3
  • 8
    • 0035967146 scopus 로고    scopus 로고
    • Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
    • Stamper C C, Zhang Y, Tobin J F, et al. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature, 2001, 410: 608-611.
    • (2001) Nature , vol.410 , pp. 608-611
    • Stamper, C.C.1    Zhang, Y.2    Tobin, J.F.3
  • 9
    • 0037089648 scopus 로고    scopus 로고
    • Ligand binding sites of inducible costimulator and high avidity mutants with improved function
    • Wang S, Zhu G, Tamada K, et al. Ligand binding sites of inducible costimulator and high avidity mutants with improved function. J Exp Med, 2002, 195: 1033-1041.
    • (2002) J Exp Med , vol.195 , pp. 1033-1041
    • Wang, S.1    Zhu, G.2    Tamada, K.3
  • 10
    • 12144290320 scopus 로고    scopus 로고
    • Structural and functional analysis of the costimulatory receptor programmed death-1
    • Zhang X, Schwartz J C, Guo X, et al. Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity, 2004, 20: 337-347.
    • (2004) Immunity , vol.20 , pp. 337-347
    • Zhang, X.1    Schwartz, J.C.2    Guo, X.3
  • 11
    • 0038185203 scopus 로고    scopus 로고
    • Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction
    • Wang S, Bajorath J, Flies D B, et al. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J Exp Med, 2003, 197: 1083-1091.
    • (2003) J Exp Med , vol.197 , pp. 1083-1091
    • Wang, S.1    Bajorath, J.2    Flies, D.B.3
  • 12
    • 42949160646 scopus 로고    scopus 로고
    • The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
    • Lin D Y, Tanaka Y, Iwasaki M, et al. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci USA, 2008, 105: 3011-3016.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3011-3016
    • Lin, D.Y.1    Tanaka, Y.2    Iwasaki, M.3
  • 13
    • 48749095324 scopus 로고    scopus 로고
    • Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2
    • Lazar-Molnar E, Yan Q, Cao E, et al. Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. Proc Natl Acad Sci USA, 2008, 105: 10483-10488.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10483-10488
    • Lazar-Molnar, E.1    Yan, Q.2    Cao, E.3
  • 14
    • 4444369694 scopus 로고    scopus 로고
    • B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse
    • Pentcheva-Hoang T, Egen J G, Wojnoonski K, et al. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity, 2004, 21: 401-413.
    • (2004) Immunity , vol.21 , pp. 401-413
    • Pentcheva-Hoang, T.1    Egen, J.G.2    Wojnoonski, K.3
  • 15
    • 36749010774 scopus 로고    scopus 로고
    • Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
    • Pentcheva-Hoang T, Chen L, Pardoll D M, et al. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability. Proc Natl Acad Sci USA, 2007, 104: 17765-17770.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17765-17770
    • Pentcheva-Hoang, T.1    Chen, L.2    Pardoll, D.M.3
  • 16
    • 0024539057 scopus 로고
    • Structure of tumour necrosis factor
    • Jones E Y, Stuart D I, Walker N P. Structure of tumour necrosis factor. Nature, 1989, 338: 225-228.
    • (1989) Nature , vol.338 , pp. 225-228
    • Jones, E.Y.1    Stuart, D.I.2    Walker, N.P.3
  • 17
    • 0028353492 scopus 로고
    • The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
    • Smith C A, Farrah T, Goodwin R G. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell, 1994, 76: 959-962.
    • (1994) Cell , vol.76 , pp. 959-962
    • Smith, C.A.1    Farrah, T.2    Goodwin, R.G.3
  • 18
    • 0032005028 scopus 로고    scopus 로고
    • Modularity in the TNF-receptor family
    • Naismith J H, Sprang S R. Modularity in the TNF-receptor family. Trends Biochem Sci, 1998, 23: 74-79.
    • (1998) Trends Biochem Sci , vol.23 , pp. 74-79
    • Naismith, J.H.1    Sprang, S.R.2
  • 19
    • 0027211704 scopus 로고
    • Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation
    • Banner D W, D'Arcy A, Janes W, et al. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell, 1993, 73: 431-445.
    • (1993) Cell , vol.73 , pp. 431-445
    • Banner, D.W.1    D'Arcy, A.2    Janes, W.3
  • 21
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol E A, Borriello F, Schweitzer A N, et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity, 1995, 3: 541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3
  • 22
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, Penninger J M, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science, 1995, 270: 985-988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 23
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan G Q, Yang J C, Sherry R M, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA, 2003, 100: 8372-8377.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3
  • 24
    • 65349185047 scopus 로고    scopus 로고
    • The clinical utility of inhibiting CD28- mediated costimulation
    • Linsley P S, Nadler S G. The clinical utility of inhibiting CD28- mediated costimulation. Immunol Rev, 2009, 229: 307-321.
    • (2009) Immunol Rev , vol.229 , pp. 307-321
    • Linsley, P.S.1    Nadler, S.G.2
  • 25
    • 0026738641 scopus 로고
    • Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg
    • Lenschow D J, Zeng Y, Thistlethwaite J R, et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science, 1992, 257: 789-792.
    • (1992) Science , vol.257 , pp. 789-792
    • Lenschow, D.J.1    Zeng, Y.2    Thistlethwaite, J.R.3
  • 26
    • 20044386299 scopus 로고    scopus 로고
    • Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
    • Larsen C P, Pearson T C, Adams A B, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant, 2005, 5: 443-453.
    • (2005) Am J Transplant , vol.5 , pp. 443-453
    • Larsen, C.P.1    Pearson, T.C.2    Adams, A.B.3
  • 27
    • 0028055141 scopus 로고
    • + T cells and defective antibody production in vivo
    • + T cells and defective antibody production in vivo. J Exp Med, 1994, 179: 809-17.
    • (1994) J Exp Med , vol.179 , pp. 809-817
    • Ronchese, F.1    Hausmann, B.2    Hubele, S.3
  • 28
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley P S, Greene J L, Brady W, et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity, 1994, 1: 793-801.
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3
  • 29
    • 0027937702 scopus 로고
    • Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
    • Peach R J, Bajorath J, Brady W, et al. Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J Exp Med, 1994, 180: 2049-2058.
    • (1994) J Exp Med , vol.180 , pp. 2049-2058
    • Peach, R.J.1    Bajorath, J.2    Brady, W.3
  • 30
    • 20044386299 scopus 로고    scopus 로고
    • Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
    • Larsen C P, Pearson T C, Adams A B, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant, 2005, 5: 443-453.
    • (2005) Am J Transplant , vol.5 , pp. 443-453
    • Larsen, C.P.1    Pearson, T.C.2    Adams, A.B.3
  • 31
    • 33644829825 scopus 로고    scopus 로고
    • Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways
    • Cardona K, Korbutt G S, Milas Z, et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med, 2006, 12: 304-306.
    • (2006) Nat Med , vol.12 , pp. 304-306
    • Cardona, K.1    Korbutt, G.S.2    Milas, Z.3
  • 32
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • Dong H, Zhu G, Tamada K, et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med, 1999, 5: 1365-1369.
    • (1999) Nat Med , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3
  • 33
    • 0035794314 scopus 로고    scopus 로고
    • B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    • Tseng S Y, Otsuji M, Gorski K, et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med, 2001, 193: 839-846.
    • (2001) J Exp Med , vol.193 , pp. 839-846
    • Tseng, S.Y.1    Otsuji, M.2    Gorski, K.3
  • 34
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity, 1999, 11: 141-151.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3
  • 35
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    • Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science, 2001, 291: 319-322.
    • (2001) Science , vol.291 , pp. 319-322
    • Nishimura, H.1    Okazaki, T.2    Tanaka, Y.3
  • 36
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman Y, Wood C R, Chernova T, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol, 2001, 2: 261-268.
    • (2001) Nat Immunol , vol.2 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 37
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman G J, Long A J, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med, 2000, 192: 1027-1034.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 38
    • 0038491416 scopus 로고    scopus 로고
    • + T cells independent of the PD-1 receptor
    • + T cells independent of the PD-1 receptor. J Exp Med, 2003, 198: 31-38.
    • (2003) J Exp Med , vol.198 , pp. 31-38
    • Shin, T.1    Kennedy, G.2    Gorski, K.3
  • 39
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte M J, Keir M E, Phamduy T B, et al. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity, 2007, 27: 111-122.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3
  • 40
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome S E, Salomao D R, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med, 2002, 8: 793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 41
    • 65349156913 scopus 로고    scopus 로고
    • Costimulatory and coinhibitory receptors in anti-tumor immunity
    • Driessens G, Kline J, Gajewski T F. Costimulatory and coinhibitory receptors in anti-tumor immunity. Immunol Rev, 2009, 229: 126-144.
    • (2009) Immunol Rev , vol.229 , pp. 126-144
    • Driessens, G.1    Kline, J.2    Gajewski, T.F.3
  • 42
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber D L, Wherry E J, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature, 2006, 439: 682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3
  • 43
    • 42649125225 scopus 로고    scopus 로고
    • PD-1 and its ligands in tolerance and immunity
    • Keir M E, Butte M J, Freeman G J, et al. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol, 2008, 26: 677-704.
    • (2008) Annu Rev Immunol , vol.26 , pp. 677-704
    • Keir, M.E.1    Butte, M.J.2    Freeman, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.