Ligand binding sites of inducible costimulator and high avidity mutants with improved function

Journal of Experimental Medicine

Volumn 195, Issue 8, 2002, Pages 1033-1041

  Wang, Shengdian ^a   Zhu, Gefeng ^a   Tamada, Koji ^a   Chen, Lieping ^a   Bajorath, Jürgen ^b,c  

^a MAYO GRADUATE SCHOOL   (United States)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Avidity; CD28; ICOS; Molecular model; Mutagenesis

Indexed keywords

ALLOANTIGEN; B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MUTANT PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMORAL IMMUNITY; IMMUNE RESPONSE; LIGAND BINDING; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BINDING SITES; CARRIER PROTEINS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037089648     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011607     Document Type: Article

References (29)

1. CD28/B7 system of T cell costimulation
2. Co-stimulation in T cell responses
3. The central effectors of cell death in the immune system
4. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
5. CTLA-4 ligation blocks CD28-dependent T cell activation
6. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
7. The T cell activation molecule H4 and the CD28-like molecule ICOS are identical
8. Expression of the novel T cell activation molecule hpH4 in HIV-infected patients: Correlation with the disease status
9. Costimulation of T cells by a B7-H2, a B7-like molecule that binds ICOS
10. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα
11. T-cell co-stimulation through B7RP-1 and ICOS
12. Identification of GL50, a novel 137-like protein that functionally binds to ICOS receptor
13. LICOS, a primordial costimulatory ligand?
14. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS
15. Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand
16. + T cells
17. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
18. Characterization of human inducible costimulator ligand expression and function
19. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE
20. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses
21. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
22. ICOS is critical for CD40-mediated antibody class switching
23. ICOS co-stimulatory receptor is essential for T-cell activation and function
24. ICOS is essential for effective T-helper-cell responses
25. Complementarity determining region1 (CDR1)- and CDR2-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
26. Solution structure of human CD152 and delineation of a CD80/CD86 binding site conserved in CD28
27. Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family
28. Molecular model of inducible costimulator protein and three-dimensional analysis of its relation to the CD28 family of T cell-specific costimulatory receptors
29. Induction, binding specificity and function of human ICOS