Radiobiological effects of hypoxia-dependent uptake of 64Cu- ATSM: Enhanced DNA damage and cytotoxicity in hypoxic cells

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 2, 2010, Pages 330-338

  Weeks, Amanda J ^a   Paul, Rowena L ^b   Marsden, Paul K ^b   Blower, Philip J ^b   Lloyd, Daniel R ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

64Cu; Cytotoxicity; DNA damage; Hypoxia

Indexed keywords

COPPER 64; DIACETYL BIS ((4) METHYLTHIOSEMICARBAZONE); DIAGNOSTIC AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; RADIOISOTOPE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANOXIA; ARTICLE; ATMOSPHERE; AUGER ELECTRON SPECTROSCOPY; CELL STRAIN MCF 7; CELL SURVIVAL; CLONOGENESIS; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; HUMAN; HUMAN CELL; HYPOXIA; HYPOXIC CELL; OXYGEN CONCENTRATION; POSITRON EMISSION TOMOGRAPHY; RADIOBIOLOGY; RADIOSENSITIVITY; WESTERN BLOTTING;

BIOLOGICAL TRANSPORT; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ORGANOMETALLIC COMPOUNDS; OXYGEN; RADIOBIOLOGY; THIOSEMICARBAZONES;

EID: 77949264268     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-009-1305-8     Document Type: Article

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