Methylation of the imidazole side chains of the Alzheimer disease amyloid-β peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

Journal of Biological Chemistry

Volumn 280, Issue 14, 2005, Pages 13355-13363

  Tickler, Anna K ^a,b   Smith, Danielle G ^a,b   Ciccotosto, Giuseppe D ^a,b   Tew, Deborah J ^a,b   Curtain, Cyril C ^a,b,c   Carrington, Darryl ^a,b   Masters, Colin L ^a,b   Bush, Ashley I ^a,b,d   Cherny, Robert A ^a,b   Cappai, Roberto ^a,b   Wade, John D ^a   Barnham, Kevin J ^a,b  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; ENZYMES; HYDROGEN PEROXIDE; POLYPEPTIDES; TOXICITY;

FIBRILS; NEURODEGENERATION; NEUROTOXICITY; REDOX ACTIVE METAL IONS;

DISEASES;

AMYLOID BETA PROTEIN; IMIDAZOLE DERIVATIVE; SUPEROXIDE DISMUTASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; METHYLATION; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SUBSTITUTION REACTION; SURFACE PROPERTY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BINDING SITES; CIRCULAR DICHROISM; COPPER; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; FREE RADICAL SCAVENGERS; HISTIDINE; HUMANS; IMIDAZOLES; METHYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEUROTOXINS; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; SUPEROXIDE DISMUTASE;

EID: 20244381121     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414178200     Document Type: Article

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