Examining the zinc binding site of the amyloid-β peptide

European Journal of Biochemistry

Volumn 267, Issue 22, 2000, Pages 6692-6698

  Yang, Dun Sheng ^a   McLaurin, Joanne ^a   Qin, Kefeng ^b   Westaway, David ^b   Fraser, Paul E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alzheimer's disease; Amyloid ; Fibril formation; Senile plaques; Zinc

Indexed keywords

ALANINE; AMYLOID BETA PROTEIN; CARBOXYLIC ACID DERIVATIVE; CYSTEINE; HISTIDINE; ZINC;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHELATION; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ELECTRON MICROSCOPY; FIBER; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION;

AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; BINDING SITES; CIRCULAR DICHROISM; CYSTEINE; HISTIDINE; MICROFIBRILS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; ZINC;

EID: 0033747946     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01767.x     Document Type: Article

References (47)

1. Aβ amyloidogenesis: Unique, or variation on a systemic theme?
2. Translating cell biology into therapeutic advances in Alzheimer's disease
3. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
4. Amyloid plaque core protein in Alzheimer's disease and Down's syndrome
5. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
6. Basement membranes, microfibrils and β-amyloid fibrillogenesis in Alzheimer's disease: High resolution ultrastructural findings
7. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
8. Mechanisms of neuronal degeneration in Alzheimer's disease
9. Amyloid β-protein fibrillogenesis: Structure and biological activity of protofibrillar intermediates
10. Protofibrillar intermediate of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
11. Solution structures of β-peptide and its constituent fragments: Relation to amyloid deposition
12. Amyloid β-peptide is produced by cultured cells during normal metabolism
13. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
14. Production of the Alzheimer amyloid beta peptide by normal proteolytic processing
15. Seeding one-dimensional crystallization of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
16. Structural neurology: Are seeds at the root of neuronal degeneration?
17. Fibril formation by primate, rodent, and Dutch-Hemorrhagic analogues of Alzheimer amyloid β-protein
18. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs
19. pH-dependent structural transitions of Alzheimer amyloid peptides
20. Phosphatidylinositol and inositol involvement in Alzheimer amyloid-β fibril growth and arrest
21. Manipulating the amyloid-β aggregation pathway with chemical chaperones
22. Apolipoprotein E associates with β amyloid peptide of Alzheimer's disease to form novel monofibrils
23. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer's beta-protein into filaments
24. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implication for the pathogenesis and treatment of Alzheimer's disease
25. An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain
26. Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability
27. Interactions of Aβ peptides with glycosaminoglycans: Effects on fibril nucleation and growth
28. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
29. α1-antichymotrypsin binding to Alzheimer Aβ peptide is sequence specific and induces fibril disaggregation in vitro
30. Zinc-induced Alzheimer's Aβ1-40 aggregation is mediated by conformational factors
31. Zinc and Alzheimer's disease: Is there a link?
32. Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease
33. Aluminum, iron, and zinc ions promote aggregation of physiological concentration of β-amyloid peptide
34. Rapid induction of Alzheimer Aβ amyloid formation by zinc
35. Zinc-induced aggregation of human and rat β-amyloid peptides in vitro
36. Selective aggregation of endogenous β-amyloid peptide and soluble amyloid precursor protein in cerebrospinal fluid by zinc
37. Copper, iron and zinc in Alzheimer's disease senile plaques
38. Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion
39. Histochemically reactive zinc in plaques of the Swedish mutant β-amyloid precursor protein transgenic mice
40. Dramatic aggregation of Alzheimer Aβ by Cu (II) is induced by conditions representing physiological acidosis
41. Modulation of Aβ adhesiveness and secretase site cleavage by zinc
42. Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis
43. The carboxyl terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implication for the pathogenesis of Alzheimer's disease
44. Kinetic theory of fibrillogenesis of amyloid beta-protein
45. Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the Aβ peptide of Alzheimer's disease
46. Synthetic peptide homologous to β protein from Alzheimer's disease forms amyloid-like fibrils in vitro
47. Conformational and fibrillogenesis of Alzheimer Aβ peptides with selected substitution of charged residues