Immunosenescence of polymorphonuclear neutrophils

TheScientificWorldJournal

Volumn 10, Issue , 2010, Pages 145-160

  Wessels, Inga ^a   Jansen, Judith ^a   Rink, Lothar ^a   Uciechowski, Peter ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Adhesion; Aging; Apoptosis; Chemotaxis; Degranulation; Elderly; fMLP; G CSF; GM CSF; Immunosenescence; Inflammaging; Inflammation; Intracellular killing; Membrane fluidity; Neutrophils; Phagocytosis; Polymorphonuclear leukocytes; Polymorphonuclear neutrophils; SENIEUR protocol; Signaling; Toll like receptor; Triggering receptor expressed on myeloid cells

Indexed keywords

ANTINEOPLASTIC AGENT;

ADAPTIVE IMMUNITY; AGING; ANTIGEN PRESENTING CELL; APOPTOSIS; CELL ADHESION; CELL AGING; CELL COUNT; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; DONOR; GENETIC DISORDER; GERIATRIC PATIENT; HUMAN; IMMUNE SYSTEM; IMMUNITY; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INFECTION SENSITIVITY; MEDICAL RESEARCH; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; PUBLIC HEALTH; RESPIRATORY BURST; SENESCENCE; SHORT SURVEY; SIGNAL TRANSDUCTION;

AGING; ANTIGEN-PRESENTING CELLS; APOPTOSIS; CHEMOTAXIS, LEUKOCYTE; HUMANS; IMMUNOLOGIC FACTORS; MODELS, BIOLOGICAL; NEUTROPHILS; PHAGOCYTOSIS; SIGNAL TRANSDUCTION;

MURINAE;

EID: 77749248871     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2010.14     Document Type: Short Survey

References (126)

1. Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M.P., Laura, Invidia, L., Celani, L., Scurti, S., Cevenini, E., Castellani, G.C., and Salvioli, S. (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 128, 92-105.
2. Ligthart, G.J., Corberand, J.X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Mullerhermelink, H.K., and Steinmann, G.G. (1984) Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Ageing Dev. 28, 47-55.
3. Nathan, C. (2006) Neutrophils and immunity: challenges and opportunities. Nat. Rev. 6, 173-182.
4. Morrison, S.J. and Spradling, A.C. (2008) Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 132, 598-611.
5. Waterstrat, A., Oakley, E., Miller, A., Swiderski, C., Liang, Y., and Van Zant, G. (2008) Mechanisms of stem cell ageing. In Telomeres and Telomerase in Ageing, Disease, and Cancer. Rudolph, K.L., Ed. Springer-Verlag. pp. 111-140.
6. Gale, R.E., Fielding, A.K., Harrison, C.N., and Linch, D.C. (1997) Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age. Br. J. Haematol. 98, 512-519.
7. Chambers, S.M., Shaw, C.A., Gatza, C., Fisk, C.J., Donehower, L.A., and Goodell, M.A. (2007) Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 5, e201.
8. Linton, P.J. and Dorshkind, K. (2004) Age-related changes in lymphocyte development and function. Nat. Immunol. 5, 133-139.
9. Min, H., Montecino-Rodriguez, E., and Dorshkind, K. (2006) Effects of aging on the common lymphoid progenitor to pro-B cell transition. J. Immunol. 176, 1007-1012.
10. Geiger, H. and Rudolph, K.L. (2009) Aging in the lympho-hematopoieticstem cell compartment. Trends Immunol. 30, 360-365.
11. Rink, L., Nicklas, W., Alvarez-Ossorios, L., Fagin, U., and Kirchner, H. (1997) Microbial superantigens stimulate T cells by the superantigen-bridge and independently by a cytokine pathway. Cytokine Res. 17, 489-499.
12. Maue, A.C., Yager, E.J., Swain, S.L., Woodland, D.L., Blackman, M.A., and Haynes, L. (2009) T-cell immunosenescence: lessons learned from mouse models of aging. Trends Immunol. 30, 301-305.
13. Cancro, M.P., Hao, Y., Scholz, J.L., Riley, R.L., Frasca, D., Dunn-Walters, D.K., and Blomberg, B.B. (2009) B cells and aging: molecules and mechanisms. Trends Immunol. 30, 313-318.
14. Chen, W.H., Kozlovsky, B.F., Effros, R.B., Grubeck-Loebenstein, B., Edelman, R., and Sztein, M.B. (2009) Vaccination in the elderly: an immunological perspective. Trends Immunol. 30, 351-359.
15. Weng, N., Akbar, A.N., and Goronzy, J. (2009) CD28S T cells: their role in the age associated decline of immune function. Trends Immunol. 30, 306-312.
16. Gibson, K.L., Wu, Y.-C., Barnett, Y., Duggan, O., Vaughan, R., Kondeatis, E., Nilsson, B.-O., Wikby, A., Kipling, D., and Dunn-Walters, D.K. (2009) B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell 8, 18-25.
17. Clark, J.A. and Peterson, T.C. (1994) Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide. Mech. Ageing Dev. 77, 127-139.
18. Delpedro, A.D., Barjavel, M.J., Mamdough, Z., Faure, S., and Bakouche, O. (1998) Signal transduction in LPS-activated aged and young monocytes. J. Interferon Cytokine Res. 18, 429-437.
19. Mariani, E., Meneghetti, A., Neri, S., Ravaglia, G., Forti, P., Cattini, L., and Facchini, A. (2002) Chemokine production by natural killer cells from nonagenarians. Eur. J. Immunol. 32, 1524-1529.
20. Gabriel, P., Cakman, I., and Rink, L. (2002) Overproduction of monokines by leukocytes after stimulation with lipopolysaccharide in the elderly. Exp.Gerontol. 37, 235-247.
21. Gon, Y., Hashimoto, S., Hayashi, S., Koura, T., Matsumoto, K., and Horie, T. (1996) Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin. Exp. Immunol. 106, 120-126.
22. van Duin, D. and Shaw A.C. (2007) Toll-like receptors in older adults. J. Am. Geriatr. Soc. 55, 1438-1444.
23. Kong, K.-F., Delroux, K., Wang, X., Qian, F., Arjon, A., Malawista, S.E., Fikrig, E., and Montgomery, R.R. (2008) Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J. Virol. 82, 7613-7623.
24. Ashcroft, G.S., Horan, M.A., and Ferguson, M.W. (1998) Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing. Lab. Invest. 78, 45-58.
25. Agrawal, A., Agrawal, S., Cao, J.N., Su, H., Osann, K., and Gupta, S. (2007) Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3- kinase-signaling pathway. J. Immunol. 178, 6912-6922.
26. Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M., Ravetch, J.V., Steinman, R.M., and Nussenzweig, M.C. (2001) Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194, 769-779.
27. Steinman, R.M., Turley, S., Mellman, I., and Inaba, K. (2000) The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191, 411-416.
28. Steinman, R.M., Hawiger, D., and Nussenzweig, M.C. (2009) Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685-711.
29. Aydar, Y., Balogh, P., Tew, J., and Szakal, A.K. (2002) Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation. Eur. J. Immunol. 32, 2817-2826.
30. Holmes, K.L., Schnitzlein, C.T., Perkins, E.H., and Tew, J. (1984) The effect of age on antigen retention in lymphoid follicles and in collagenous tissue of mice. Mech. Ageing Dev. 25, 243-255.
31. Greiwe, J.S., Cheng, B., Rubin, D.C., Yarasheski, K.E., and Semenkovich C.F. (2001) Resistance exercise decreases skeletal muscle tumor necrosis factor in frail elderly humans. FASEB J. 15, 475-482.
32. Steger, M.M., Maczek, C., and Grubeck-Loebenstein, B. (1996) Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals. Clin. Exp. Immunol. 105, 544-550.
33. Donnini, A., Argentati, K., Mancini, L., Smorlesi, A., Bartozzi, B., Bernardini, G., and Provinciali, M. (2002) Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age. Exp. Gerontol. 37, 1097-1112.
34. Komatsubara, S., Cinader, B., and Muramatsu, S. (2006) Functional competence of dendritic cells of ageing C57BL/6 mice. Scand. J. Immunol. 24, 517-525.
35. Linton, P.J., Haynes, L., Klinman, N.R., and Swain, S.L. (1996) Antigen-independent changes in naive CD4 T cells with aging. J. Exp. Med. 184, 1891-1900.
36. Tesar, B.M., Walker, W.E., Unternaehrer, J., Joshi, N.S., Chandele, A., Haynes, L., Kaech, S., and Goldstein, D.R. (2006) Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell 5, 473-486.
37. Agrawal, A., Agrawal, S., and Gupta, S. (2009) Role of dendritic cells in aging. In Handbook on Immunosenescence. Fulop, T. et al., Eds. Springer Netherlands. pp. 499-510.
38. Panda, A., Arjona, A., Sapey, E., Bai, F., Fikrig, E., Montgomery, R., Lord, J.M., and Shaw, C.A. (2009) Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol. 30, 325-333.
39. Uciechowski, P. and Rink, L. (2009) Neutrophil granulocyte functions in the elderly. In Handbook on Immunosenescence. Fulop, T. et al., Eds. Springer Netherlands. pp. 439-455.
40. Schröder, A.K., von der Ohe, M., Kolling, U., Altstaedt, J., Uciechowski, P., Fleischer, D., Dalhoff, K., Ju, X., Zenke, M., Heussen, N., and Rink, L. (2006) Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators. Immunology 119, 317-327.
41. Hellewell, P.G. and Williams, T.J. (1994) The Neutrophil. In The Handbook of Immunopharmacology: Immunopharmacology of Neutrophils. Page, C. et al., Eds. Academic Press.
42. Prentki, M., Wollheim, C.B., and Lewgn, P.D. (1984) Ca2+ homeostasis in permeabilized human neutrophils. J. Biol. Chem. 259, 13777-13782.
43. Kovacs, E.J., Palmer, J.L., Fortin, C.F., Fulop, T., Jr., Goldstein, D.R., and Linton, P.J. (2009) Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors. Trends Immunol. 30, 319-324.
44. Fortin, C.F., Lesur, O., and Fulop, T., Jr. (2007) Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4. Intern. Immunol. 19, 41-50.
45. Fortin, C.F., Ear, T., and McDonald, P.P. (2009) Autocrine role of endogenous interleukin-18 on inflammatory cytokine generation by human neutrophils. FASEB J. 23, 194-203.
46. Schroeder, A.K. and Rink, L. (2003) Neutrophil immunity of the elderly. Mech. Ageing Dev. 124, 419-425.
47. Gomez, C.R., Nomellini, V., Faunce, D.E., and Kovacs, E.J. (2008) Innate immunity and aging. Exp. Gerontol. 43, 718-728.
48. Hannah, S., Mecklenburgh, K., Rahman, I., Bellingan, G.J., Greening, A., Haslett, C., and Chilvers, E.R. (1995) Hypoxia prolongs neutrophil survival in vitro. FEBS Lett. 372, 233-237.
49. Laupland, K.B., Deirdre, L., Church, D.L., Mucenski, M., Sutherland, L.R., and Davies, H.D. (2003) Population-based study of the epidemiology of and the risk factors for invasive Staphylococcus aureus infections. J. Infect. Dis. 187, 1452-1459.
50. Fortin, C.F., Larbi, A., Dupuis, G., and Fulop, T. (2009) Signal transduction changes in fMLP, TLRs, TREM-1 and GM-CSF receptors in PMN with aging. In Handbook on Immunosenescence. Fulop, T. et al., Eds. Springer Netherlands. pp. 457-474.
51. Chatta, G.S., Andrews, R.G., Rodger, E., Schrag M., and Dale, D.C. (1993) Hematopoietic progenitors and aging: alterations in granulocyte precursors and responsiveness to recombinant human G-CSF, GM-CSF and IL-3. J.Gerontol. 48, M207.
52. Lord, J.M., Butcher, S., Killampali, V., Lascelles, D., and Salmon, M. (2001) Neutrophil ageing and immunosenescence. Mech. Ageing Dev. 122, 1521-1535.
53. Born, J., Uthgenannt, D., Dodt, C., Nunninghoff, D., Ringvolt, E., Wagner, T., and Fehm, H.-L. (1995) Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep. Mech. Ageing Dev. 84, 113.
54. Albright, J.F. and Albright, J.W. (2003) Aging, Immunity, and Infection. Humana Press, Totowa, NJ. pp. 61-135.
55. Fulop, T., Jr., Fouquet, C., Allaire, P., Perrin, N., Lacombe, G., Stankova, J., Rola-Pleszczynski, M., Gagné, D., Wagner, J.R., Khalil, A., and Dupuis, G. (1997) Changes in apoptosis of human polymorhonuclear granulocytes with aging. Mech. Ageing Dev. 96, 15-34.
56. Tortorella, C., Simone, O., Piazzolla, G., and Stella, I. (2006) Role of phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways in granulocyte macrophage-colony-stimulating factor failure to delay Fas-induced neutrophil apoptosis in elderly humans. J. Gerontol. 61A, 1111-1118.
57. Fortin, C.F., Lesur, O., and Fulop, T., Jr. (2007) Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functions. FEBS Lett. 581, 1173-1178.
58. Fulop, T., Larbi, A., Douziech, N., Fortin, C., Guérard, K.-P., Lesur, O., Khalil, A., and Dupuis, G. (2004) Signal transduction and functional changes in neutrophils with aging. Ageing Cell 3, 217-226.
59. Tortorella, C., Piazzolla, G., Spaccavento, F., Jirillo, E., and Antonaci, S. (1999) Age-related effects of oxidative metabolism and cyclic AMP signaling on neutrophil apoptosis. Mech. Ageing Dev. 110, 195-205.
60. Vandavier, R.W., Henson, P.M., and Douglas, I.S. (2006) Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest 129, 1673-1682.
61. Leng, S.X., Xue, Q.L., Tian, J., Walston, J.D., and Fried, L.P. (2007) Inflammation and frailty in older women. J. Am. Geriatr. Soc. 55, 864-871.
62. Fortin, C.F., McDonald, P.P., Lesur, O., and Fulop, T., Jr. (2008) Aging and neutrophils: there is still much to do. Rejuv. Res. 11, 873-882.
63. Alonso-Fernandez, P., Puerto, M., Maté, I., Reibera, J.M., and de la Fuente, M. (2008) Neutrophils of centenarians show function levels similar to those of young adults. J. Am. Geriatr. Soc. 56, 2244-2251.
64. Di Lorenzo, G., Balistreri, C.R., Candore, G., Cigna, D., Colombo, D., Romano, G.C., Colucci, A.T., Gervasi, F., Listi, F., Potestio, M., and Caruso, C. (1999) Granulocyte and natural killer activity in the elderly. Mech. Ageing Dev. 108, 25-38.
65. Corberand, J.X., Laharrague, P.F., and Fillola, G. (1986) Neutrophils of healthy aged humans are normal. Mech. Ageing Dev. 36, 63.
66. Niwa, Y., Kasama, T., Myachi, Y., and Kanoh, T. (1989) Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies. Life Sci. 44, 1655-1664.
67. MacGregor, R., Spagnuolo, P.L., and Lentnek, A.L. (1974) Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system. N. Engl. J. Med. 291, 642-646.
68. Walrand, S., Moreau, K., Caldefie, F., Tridon, A., Portefaix, G., Cynober, L., Beaufrère, B., Vasson, M.P., and Boirie, Y. (2001) Specific and nonspecific immune responses to fasting and refeeding differ in healthy young adult and elderly persons. Am. J. Clin. Nutr. 74, 670-678.
69. Antonaci, S., Jirillo, E., Ventura, M.T., Garofalo, A.R., and Bonomo, L. (1984) Non-specific immunity in aging: deficiency of monocyte and polymorphonuclear cell-mediated functions. Mech. Ageing Dev. 24, 367-375.
70. Rao, K.M. (1986) Age-related decline in ligand-induced actin polymerization in human leukocytes and platelets. J. Gerontol. 41, 561-566.
71. Fortin, C.F., Larbi, A., Lesur, O., Douziech, N., and Fulop, T. (2006) Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions. J. Leukoc. Biol. 79, 1061-1072.
72. De la Funete, M., Hernandez, A., and Vallejo, M.C. (2005) The immune system in the oxidative stress conditions of aging and hypertension: favorable effects of antioxidants and physical exercise. Antioxid. Redox. Signal. 7, 1356-1366.
73. Wenisch, C., Patruta, S., Daxböck, F., Krause, R., and Hörl, W. (2000) Effect of age on human neutrophil function. J. Leukoc. Biol. 67, 40-45.
74. Swift, M.E., Burns, A.L., Gray, K.L., and DiPetro, L.A. (2001) Age-related alterations in the inflammatory response to dermal injury. J. Invest. Dermatol. 117, 1027-1035.
75. Singh, P., Coskun, Z.Z., Goode, C., Dean, A., Thompson-Snipes, L., and Darlington, G. (2008) Lymphoid neogenesis and immune infiltration in aged liver. Hepatology 47, 1680-1690.
76. Nomellini, V., Faunce, D.E., Gomez, C.R., and Kovacs, E.J. (2008) An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition. J. Leukoc. Biol. 83, 1493-1501.
77. Biasi, D., Carletto, A., Dellágnola, C., Caramaschi, P., Montesanti, F., Zavateri, G., Zeminian, S., Bellavite, P., and Bambara, L.M. (1996) Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects. Inflammation 20, 673-681.
78. Placket, T.P., Boehmer, E.D., Faunce, D.E., and Kovacs, E.J. (2004) Aging and innate immune cells. J. Leukoc. Biol. 76, 291-299.
79. Butcher, S., Chahel, H., and Lord, J.M. (2000) Aging and the neutrophil: no appetite for killing? Immunology 100, 411-416.
80. Esparza, B., Sanchez, H., and Ruiz, M. (1996) Neutrophil function in elderly persons assessed by flow cytometry. Immunol. Invest. 25, 185-190.
81. Egger, G., Burda, A., Mitterhammer, H., Baumann, G., Bratschitsch, G., and Glasner, A. (2003) Impaired blood polymorphonuclear leukocytemigration and infection risk in severe trauma. J. Infect. 47, 148-154.
82. Lipschitz, D.A., Udupa, K.B., Indelicato, S.R., and Das, M. (1991) Effect of age on second messenger generation in neutrophils. Blood 78, 1347-1354.
83. Fulup, T., Jr., Fóris, G., Wórum, I., and Leövey, A. (1985) Age-dependent alterations of Fcg receptor-mediated effector functions of human polymorphonuclear leucocytes. Clin. Exp. Immunol. 61, 425-432.
84. Ito, Y., Kajkenova, O., Feuers, R.J., Udupa, K.B., Desai, V.G., Epstein, J., and Hart, R.W. (1998) Impaired glutathione peroxidase activity accounts for the age-related accumulation of hydrogen peroxide in activated human neutrophils. J. Gerontol. A Biol. Sci. Med. Sci. 53, M169-M175.
85. Tortorella, C., Piazzolla, G., Spaccavento, F., Vella, F., Pace, L., and Antonaci, S. (2000) Regulatory role of extracellular matrix proteins in neutrophil respiratory burst during aging. Mech. Ageing Dev. 119, 69-82.
86. Tortorella, C., Simone, O., Piazzolla, G., Stella, I., and Antonaci, S. (2007) Age-related impairment of GM-CSF induced signalling in neutrophils: role of SHP-1 and SOCS proteins. Ageing Res. Rev. 6, 81-93.
87. Seres, I., Csongor, I., Mohacsi, A., Leövey, A., and Fulop, T. (1993) Age-dependent alterations of human recombinant GM-CSF effects on human granulocytes. Mech. Ageing Dev. 71, 143.
88. Braga, P.C., Sala, M.T., Dal Sasso, M., Mancini, L., Sandrini, M.C., and Annoni, G. (1997) Influence of age on oxidative bursts (chemiluminescence) of polymorphonuclear neutrophil leukocytes. Gerontology 44, 192.
89. Fulop, T., Jr. and Seres, I. (1994) Signal transduction changes in granulocytes and lymphocytes with aging. Immunol. Lett. 40, 259.
90. Polignano, A., Tortorella, C., Venezia, A., Jirillo, E., and Antonaci, S. (1994) Age-associated changes of neutrophil responsiveness in a human healthy elderly population. Cytobios 80, 145-153.
91. McLaughlin, B., O'Malley, K., and Cotter, T.G. (1986) Age-related differences in granulocyte chemotaxis and degranulation. Clin. Sci. 70, 59.
92. Whitelaw, D.A., Rayner, B.L., and Willcox, P.A. (1992) Community-acquired bacteremia in the elderly-a prospective study of 121 cases. J. Am. Geriatr. Soc. 40, 996.
93. Klut, M.E., Ruehlmann, D.O., Li, L., Whalen, B.A., Van Breemen, C., and Hogg, J.C. (2002) Age-related changes in the calcium homeostasis of adherent neutrophils. Exp. Gerontol. 37, 533-541.
94. Bhushan, M., Cumberbatch, M., Dearman, R., Andrew, S.M., Kimber, I., and Griffiths, C.E. (2002) Tumour necrosis factoralpha-induced migration of human Langerhans cells: the influence of ageing. Br. J. Dermatol. 146, 32-40.
95. Altstaedt, J., Kirchner, H., and Rink, L. (1996) Cytokine production of neutrophils is limited to interleukin-8. Immunology 89, 563-568.
96. von der Ohe, M., Altstaedt, J., Gross, U., and Rink, L. (2001) Human neutrophils produce macrophage inhibitory protein-1 beta but not type 1 interferons in response to viral stimulation. Interferon Cytokine Res. 21, 241-247.
97. Kasama, T., Miwa, Y., Izozaki, T., Adachi, M., and Kunkel, S.L. (2005) Neutrophil-derived cytokines: potential therapeutic targets in inflammation. Curr. Drug Targets Immune Endocr. Metabol. Disord. 4, 273-279.
98. Ferretti, S., Bonneau, O., Dubois, G.R., Jones, C.E., and Trifilieff, A. (2003) IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol. 170, 2106-2112.
99. Denkers, E.Y. (2003) From cells to signaling cascades: manipulation of innate immunity by Toxoplasma gondii. FEMS Immunol. Med. Microbiol. 39, 193.
100. Lloyd, A.R. and Oppenheim, J.J. (1992) Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Immunol. Today 13, 167-172.
101. Cassatella, M.A. (1995) The production of cytokines by polymorphonuclear neutrophils. Immunol. Today 16, 21-26.
102. Reato, G., Cuffini, A.M., Tullio, V., Palarchio, A.I., Bonini, A., Foa, R., and Carlone, N.A. (1999) Co-amoxiclav affects cytokine production by human polymorphonuclear cells. J. Antimicrob. Chemother. 43, 715-718.
103. Rink, L., Cakman, I., and Kirchner, H. (1998) Altered cytokine production in the elderly. Mech. Ageing Dev. 102, 199.
104. Wessels, I., Fleischer, D., Rink, L., and Uciechowski, P. (2010) Changes in chromatin structure and methylation of the human Interleukin-1β gene during monopoiesis. Immunology, in press.
105. DeMartinis, M., Modesti, M., and Ginaldi, L. (2004) Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons. Immunol. Cell Biol. 82, 415-420.
106. Larbi, A., Douziech, N., Fortin, C., Linteau, A., Dupuis, G., and Fulop, T., Jr. (2005) The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun. Ageing 2, 64-74.
107. Okuda, K., Tani, K., Ishigatsubo, Y., Yokota, S., and David, C.S. (1980) Antigen-pulsed neutrophils bearing antigens can induce T lymphocyte proliferative response to the syngeneic or semisygeneic antigen-primed T lymphocytes. Transplantation 30, 368-372.
108. Alvarez, E., Ruiz-Gutiérrez, V., Sobrino, F., and Santa-Maria, C. (2009) Age-related changes in membrane lipid composition, fluidity and respiratory burst in rat peritoneal neutrophils. Clin. Exp. Immunol. 124, 95-102.
109. Gosselini, E.J., Wardwell, K., Rigby, W.F., and Guyre, P.M. (1993) Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3. J. Immunol. 151, 1482-1490.
110. Fanger, N.A., Liu, C., Guyre, P.M., Wardwell, K., O'Neill, J., Guo, T.L., Christian, T.P., Mudzinski, S.P., and Gosselini, E.J. (1997) Activation of human T cells by major histocompatability complex class II expressing neutrophils: proliferation in the presence of superantigen, but not tetanus toxoid. Blood 89, 4128-4135.
111. Iking-Konert, C., Wagner, C., Denefleh, B., Hug, F., Schneider, M., Andrassy, K., and Hansch, G.M. (2009) Up-regulation of the dendritic cell marker CD83 on polymorphonuclear neutrophils (PMN): divergent expression in acute bacterial infections and chronic inflammatory disease. Clin. Exp. Immunol. 130, 501-508.
112. Wilson, D.M., III, Bohr, V.A., and McKinnon, P.J. (2008) DNA damage, DNA repair, ageing and age-related disease. Mech. Ageing Dev. 129, 349-352.
113. Wang, S.-C., Oelze, B., and Schumacher, A. (2009) Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS 3, 1-11.
114. Issa, J.P. (2003) Age-related epigenetic changes and the immune system. Clin. Immunol. 109, 103-108.
115. Kim, K.C., Friso, S., and Choi, S.W. (2009) DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J. Nutr. Biochem. 20, 917-926.
116. Haase, H. and Rink, L. (2009) The immune system and the impact of zinc during aging. Immun. Ageing 6, 9.
117. Shankar, A.H. and Prasad, A.S. (1998) Zinc and immune function: the biological basis of altered resistance to infection. Am. J. Clin. Nutr. 68, 447S-463S.
118. Haase, H. and Rink, L. (2009) Functional significance of zinc-related signaling pathways in immune cells. Annu. Rev. Nutr. 29, 133-152.
119. Prasad, A.S., Bao, B., Beck, F.W., and Sarkar, F.H. (2006) Correction of interleukin-2 gene expression by in vitro zinc addition to mononuclear cells from zinc-deficient human subjects: a specific test for zinc deficiency in humans. Transl. Res. 148, 325-333.
120. Munder, M. (2009) Arginase: an emerging key player in the mammalian immune system. Br. J. Pharmacol. 158, 638-651.
121. Tortorella, C., Piazzolla, G., Spaccavento, F., Pece, S., Jirillo, E., and Antonacci, S. (1998) Spontaneous and Fas-induced apoptotic cell death in aged neutrophils. J. Clin. Immunol. 5, 321-329.
122. Mollica, L., Fleury, I., Belisle, C., Provost, S., Roy, D.C., and Busque, L. (2009) No association between telomere length and blood cell counts in elderly individuals. J. Gerontol. A Biol. Sci. Med. Sci. 64, 963-964.
123. Tortorella, C., Polignano, A., Piazolla, G., Serrone, M., Jirillo, E., and Anonaci, S. (1996) Lipopolysaccharide-, granulocyte-monocyte colony stimulating factor and pentoxifylline-mediated effects on form ylmethionyl-leucinephenilalanine-stimulated neutrophil respiratory. Microbios 85, 189-198.
124. Yoshino, T., Tamura, M., Hattori, K., Kawamura, A., Imai, N., and Ono, M. (1992) Effects of recombinant human granulocyte colony-stimulating factor on neutrophil function in normal rats. Br. J. Haematol. 82, 664-670.
125. Fu, Y.K., Arkins, S., Li, Y.M., Dantzer, R., and Kelley, K.W.(1994) Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: reversal by the combination of gamma interferon and growth hormone. Infect. Immun. 62, 1-8.
126. Chaves, M.M., Costa, D.C., Pereira, C.C., Andrade, T.R., Horta, B.C., and Nogueira-Machado, J.A. (2007). Role of inositol 1,4,5-triphosphate and p38 mitogen-activated protein kinase in reactive oxygen species generation by granulocytes in a cyclic AMPdependent manner: an age-related phenomenon. Gerontology 53, 228-233.