Differential binding of bispyridinium oxime drugs with acetylcholinesterase

Acta Pharmacologica Sinica

Volumn 31, Issue 3, 2010, Pages 313-328

  Kesharwani, Manoj K ^a   Ganguly, Bishwajit ^a   Das, Amit ^b   Bandyopadhyay, Tusar ^b  

^a CSIR CENTRAL SALT AND MARINE CHEMICALS RESEARCH INSTITUTE   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Acetylcholinesterase structure; Nerve gas; Oxime drugs; Protein drug complexes; Steered molecular dynamics simulation

Indexed keywords

ACETYLCHOLINESTERASE; BIS(PYRIDINIUM OXIME) DERIVATIVE;

ARTICLE; BINDING KINETICS; DRUG EFFICACY; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME REACTIVATION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; SIMULATION;

ACETYLCHOLINESTERASE; ANIMALS; CATALYTIC DOMAIN; HYDROGEN BONDING; HYDROPHOBICITY; MICE; MOLECULAR DYNAMICS SIMULATION; OXIMES; PROTEIN BINDING; PYRIDINIUM COMPOUNDS;

EID: 77749246102     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.193     Document Type: Article

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