2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2195-2203

  Scheiff, Anja B ^a   Yerande, Swapnil G ^b   El Tayeb, Ali ^a   Li, Wenjin ^a   Inamdar, Gajanan S ^b   Vasu, Kamala K ^b   Sudarsanam, Vasudevan ^b   Müller, Christa E ^a  

^a UNIVERSITY OF BONN   (Germany)

^b B V PATEL PHARMACEUTICAL EDUCATION AND RESEARCH DEVELOPMENT PERD CENTRE   (India)

Author keywords

Adenosine A1 receptor antagonist; Adenosine receptor; Structure activity relationships; Thiazole

Indexed keywords

2 AMINO 5 BENZOYL 4 PHENYLTHIAZOLE DERIVATIVE; 2 BENZOYLAMINO 5 METHYLBENZOYL 4 PHENYLTHIAZOLE; 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR ANTAGONIST; CAFFEINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IC 50; LIGAND BINDING; NONHUMAN; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; RATS; RECEPTOR, ADENOSINE A1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

RATTUS;

EID: 77649238025     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.072     Document Type: Article

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