A structural informatics approach to mine kinase knowledge bases

Drug Discovery Today

Volumn 15, Issue 5-6, 2010, Pages 203-209

  Brooijmans, Natasja ^a   Mobilio, Dominick ^a   Walker, Gary ^a   Nilakantan, Ramaswamy ^b   Denny, Rajiah A ^c   Feyfant, Eric ^c   Diller, David ^c   Bikker, Jack ^a   Humblet, Christine ^c  

^a WYETH RESEARCH   (United States)

^b NONE   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[3 [4 [5 [2 (3 FLUOROANILINO) 2 OXOETHYL] 1H PYRAZOL 3 YLAMINO] 7 QUINAZOLINYLOXY]PROPYL](ETHYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE; ABELSON KINASE; ADENOSINE TRIPHOSPHATE; IMATINIB; LIGAND; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; PYRROLOPYRIDINE DERIVATIVE; SORAFENIB; UNCLASSIFIED DRUG;

BINDING SITE; COMPUTER AIDED DESIGN; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DATA MINING; DRUG DESIGN; DRUG MARKETING; DRUG PROTEIN BINDING; DRUG STRUCTURE; GEOMETRY; IC 50; KNOWLEDGE BASE; PHARMACOPHORE; PROTEIN ANALYSIS; PROTEIN DATA BANK; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STRUCTURE; REVIEW; STRUCTURAL BIOINFORMATICS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; HUMANS; INFORMATICS; KNOWLEDGE BASES; MOLECULAR STRUCTURE; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77649234648     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2009.11.005     Document Type: Review

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