Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner

Journal of Cellular and Molecular Medicine

Volumn 13, Issue 10, 2009, Pages 4176-4184

  Shang, Linshan ^a   Zhou, Haibin ^a   Xia, Yu ^a   Wang, Hui ^a   Gao, Guimin ^a   Chen, Bingxi ^a   Liu, Qiji ^a   Shao, Changshun ^a,b   Gong, Yaoqin ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Gene expression; Nutritional stress; P53; Promoter; SIRT1

Indexed keywords

PROTEIN P53; SIRT1 PROTEIN, HUMAN; SIRTUIN 1; CULTURE MEDIUM;

ANIMAL; ARTICLE; CULTURE MEDIUM; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; TUMOR CELL LINE; UPREGULATION;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CULTURE MEDIA, SERUM-FREE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MOLECULAR SEQUENCE DATA; RESPONSE ELEMENTS; SIRTUIN 1; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

MUS; RODENTIA;

EID: 77449145472     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00468.x     Document Type: Article

References (32)

1. Blander G, Guarente L. The Sir2 family of protein deacetylases. Annu Rev Biochem. 2004, 73:417-35.
2. Gray SG, Ekstrom TJ. The human histone deacetylase family. Exp Cell Res. 2001, 262:75-83.
3. Aparicio OM, Billington BL, Gottschling DE. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell. 1991, 66:1279-87.
4. Rine J, Herskowitz I. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics. 1987, 116:9-22.
5. Sinclair DA, Guarente L. Extrachromosomal rDNA circles - a cause of aging in yeast. Cell. 1997, 91:1033-42.
6. Dryden SC, Nahhas FA, Nowak JE. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol. 2003, 23:3173-85.
7. Starai VJ, Celic I, Cole RN. Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science. 2002, 298:2390-2.
8. Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 1999, 13:2570-80.
9. Tissenbaum HA, Guarente L. Increased dosage of a Sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 2001, 410:227-30.
10. Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science. 2000, 289:2126-8.
11. North BJ, Verdin E. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol. 2004, 5:224.1-12.
12. Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene. 2005, 24:7410-25.
13. Motta MC, Divecha N, Lemieux M. Mammalian SIRT1 represses forkhead transcription factors. Cell. 2004, 116:551-63.
14. Picard F, Kurtev M, Chung N. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004, 429:771-6.
15. Smith J. Human Sir2 and the 'silencing' of p53 activity. Trends Cell Biol. 2002, 12:404-6.
16. Vaziri H, Dessain SK, Ng Eaton E. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 2001, 107:149-59.
17. Brunet A, Sweeney LB, Sturgill JF. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004, 303:2011-5.
18. Bordone L, Cohen D, Robinson A. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell. 2007, 6:759-67.
19. Nemoto S, Fergusson MM, Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science. 2004, 306:2105-8.
20. el-Deiry WS, Kern SE, Pietenpol JA. Definition of a consensus binding site for p53. Nat Genet. 1992, 1:45-9.
21. McLure KG, Lee PW. How p53 binds DNA as a tetramer. EMBO J. 1998, 17:3342-50.
22. Dhar SK, Xu Y, Chen Y. Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression. J Biol Chem. 2006, 281:21698-709.
23. Chen D, Steele AD, Lindquist S. Increase in activity during calorie restriction requires Sirt1. Science. 2005, 310:1641.
24. Cohen HY, Miller C, Bitterman KJ. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004, 305:390-2.
25. Kim D, Nguyen MD, Dobbin MM. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007, 26:3169-79.
26. Viswanathan M, Kim SK, Berdichevsky A. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell. 2005, 9:605-15.
27. Wei CL, Wu Q, Vega VB. A global map of p53 transcription-factor binding sites in the human genome. Cell. 2006, 124:207-19.
28. Qian H, Wang T, Naumovski L. Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites. Oncogene. 2002, 21:7901-11.
29. Contente A, Dittmer A, Koch MC. A polymorphic microsatellite that mediates induction of PIG3 by p53. Nat Genet. 2002, 30:315-20.
30. Luo J, Nikolaev AY, Imai S. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 2001, 107:137-48.
31. Motta MC, Divecha N, Lemieux M. Mammalian SIRT1 represses forkhead transcription factors. Cell. 2004, 116:551-63.
32. Jones RG, Plas DR, Kubek S. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell. 2005, 18:283-93.