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Volumn 13, Issue 9 B, 2009, Pages 3876-3887

Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells

Author keywords

CA IX; Colon cancer; COX 2; Hypoxia; Inflammation

Indexed keywords


EID: 77449140110     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00580.x     Document Type: Article
Times cited : (36)

References (49)
  • 1
    • 17244379178 scopus 로고    scopus 로고
    • Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    • author reply 464-5
    • Edge SB, Sobin LH, Page DL. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst. 2005, 97:463-4. author reply 464-5
    • (2005) J Natl Cancer Inst. , vol.97 , pp. 463-464
    • Edge, S.B.1    Sobin, L.H.2    Page, D.L.3
  • 2
    • 34247110393 scopus 로고    scopus 로고
    • Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice
    • Taniguchi K, Kakinuma S, Tokairin Y. Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice. Oncology. 2007, 71:124-30.
    • (2007) Oncology. , vol.71 , pp. 124-130
    • Taniguchi, K.1    Kakinuma, S.2    Tokairin, Y.3
  • 3
    • 33750598021 scopus 로고    scopus 로고
    • Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    • Zhang J, Stirling B, Temmerman ST. Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest. 2006, 116:3042-9.
    • (2006) J Clin Invest. , vol.116 , pp. 3042-3049
    • Zhang, J.1    Stirling, B.2    Temmerman, S.T.3
  • 4
    • 33751361302 scopus 로고    scopus 로고
    • Bacteria, inflammation, and colon cancer
    • Yang L, Pei Z. Bacteria, inflammation, and colon cancer. World J Gastroenterol. 2006, 14:6741-6.
    • (2006) World J Gastroenterol. , vol.14 , pp. 6741-6746
    • Yang, L.1    Pei, Z.2
  • 5
    • 17744418769 scopus 로고    scopus 로고
    • The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    • Steinbach G, Lynch PM, Phillips RK. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 2000, 342:1946-52.
    • (2000) N Engl J Med. , vol.342 , pp. 1946-1952
    • Steinbach, G.1    Lynch, P.M.2    Phillips, R.K.3
  • 6
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: a molecular target for colorectal cancer prevention
    • Brown JR, DuBois RN. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol. 2005, 23:2840-55.
    • (2005) J Clin Oncol. , vol.23 , pp. 2840-2855
    • Brown, J.R.1    DuBois, R.N.2
  • 7
    • 0027993458 scopus 로고
    • Up-regulation of cyclooxygenase-2 gene-expression in human colorectal adenomas and adenocarcinomas
    • Eberhart CE, Coffey RJ, Radhika A. Up-regulation of cyclooxygenase-2 gene-expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994, 107:1183-8.
    • (1994) Gastroenterology. , vol.107 , pp. 1183-1188
    • Eberhart, C.E.1    Coffey, R.J.2    Radhika, A.3
  • 8
    • 26444543238 scopus 로고    scopus 로고
    • Mechanisms for the prevention of gastrointestinal cancer: the role of prostaglandin E2
    • Backlund MG, Mann JR, Dubois RN. Mechanisms for the prevention of gastrointestinal cancer: the role of prostaglandin E2. Oncology. 2005, 69:S28-32.
    • (2005) Oncology. , vol.69
    • Backlund, M.G.1    Mann, J.R.2    Dubois, R.N.3
  • 9
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuji S. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 1998, 93:705-16.
    • (1998) Cell. , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3
  • 10
    • 1242314857 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in colorectal cancer
    • Sinicrope FA, Gill S. Role of cyclooxygenase-2 in colorectal cancer. Cancer Metastasis Rev. 2004, 23:63-75.
    • (2004) Cancer Metastasis Rev. , vol.23 , pp. 63-75
    • Sinicrope, F.A.1    Gill, S.2
  • 11
    • 0030606299 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Apc (D716) knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    • Oshima M, Dinchuk JE, Kargman SL. Suppression of intestinal polyposis in Apc (D716) knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell. 1996, 87:803-9.
    • (1996) Cell. , vol.87 , pp. 803-809
    • Oshima, M.1    Dinchuk, J.E.2    Kargman, S.L.3
  • 12
    • 33746123520 scopus 로고    scopus 로고
    • Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
    • Kaidi A, Qualtrough D, Williams AC. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res. 2006, 66:6683-91.
    • (2006) Cancer Res. , vol.66 , pp. 6683-6691
    • Kaidi, A.1    Qualtrough, D.2    Williams, A.C.3
  • 13
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulatory factor in tumor growth
    • Harris AL. Hypoxia-a key regulatory factor in tumor growth. Nat Rev Cancer. 2002, 2:38-47.
    • (2002) Nat Rev Cancer. , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 14
    • 33751543273 scopus 로고    scopus 로고
    • Hypoxia: importance in tumor biology, non invasive measurement by imaging, and value of its measurement in the management of cancer therapy
    • Tatum JL, Kelloff GJ, Gillies RJ. Hypoxia: importance in tumor biology, non invasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 2006, 82:699-757.
    • (2006) Int J Radiat Biol. , vol.82 , pp. 699-757
    • Tatum, J.L.1    Kelloff, G.J.2    Gillies, R.J.3
  • 15
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T. Hypoxia mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 1996, 379:88-91.
    • (1996) Nature. , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 16
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: significance and impact on clinical outcome
    • Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007, 26:225-39.
    • (2007) Cancer Metastasis Rev. , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 17
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    • Swinson DE, Jones JL, Richardson D. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol. 2003, 21:473-82.
    • (2003) J Clin Oncol. , vol.21 , pp. 473-482
    • Swinson, D.E.1    Jones, J.L.2    Richardson, D.3
  • 18
    • 33846211525 scopus 로고    scopus 로고
    • Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
    • Hussain SA, Ganesan R, Reynolds G. Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer. Br J Cancer. 2007, 96:104-9.
    • (2007) Br J Cancer. , vol.96 , pp. 104-109
    • Hussain, S.A.1    Ganesan, R.2    Reynolds, G.3
  • 19
    • 33751277287 scopus 로고    scopus 로고
    • CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance
    • Brennan DJ, Jirstrom K, Kronblad A. CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin Cancer Res. 2006, 12:6421-31.
    • (2006) Clin Cancer Res. , vol.12 , pp. 6421-6431
    • Brennan, D.J.1    Jirstrom, K.2    Kronblad, A.3    et al4
  • 20
    • 33646003243 scopus 로고    scopus 로고
    • Hypoxia in human colorectal adenocarcinoma: comparison between extrinsic and potential intrinsic hypoxia markers
    • Goethals L, Debucquoy A, Perneel C. Hypoxia in human colorectal adenocarcinoma: comparison between extrinsic and potential intrinsic hypoxia markers. Int J Radiat Oncol Biol Phys. 2006, 65:246-54.
    • (2006) Int J Radiat Oncol Biol Phys. , vol.65 , pp. 246-254
    • Goethals, L.1    Debucquoy, A.2    Perneel, C.3
  • 21
    • 19544381887 scopus 로고    scopus 로고
    • MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX
    • Kopacek J, Barathova M, Dequiedt F. MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX. Biochim Biophys Acta. 2005, 1729:41-9.
    • (2005) Biochim Biophys Acta. , vol.1729 , pp. 41-49
    • Kopacek, J.1    Barathova, M.2    Dequiedt, F.3
  • 22
    • 30044437912 scopus 로고    scopus 로고
    • The role of extracellular signal-regulated protein kinase in transcriptional regulation of the hypoxia marker carbonic anhydrase IX
    • Kaluz S, Kaluzová M, Stanbridge EJ. The role of extracellular signal-regulated protein kinase in transcriptional regulation of the hypoxia marker carbonic anhydrase IX. J Cell Biochem. 2006, 97:207-16.
    • (2006) J Cell Biochem. , vol.97 , pp. 207-216
    • Kaluz, S.1    Kaluzová, M.2    Stanbridge, E.J.3
  • 23
    • 33847637262 scopus 로고    scopus 로고
    • P66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres
    • Sansone P, Storci G, Giovannini C. p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres. Stem Cells. 2007, 25:807-15.
    • (2007) Stem Cells. , vol.25 , pp. 807-815
    • Sansone, P.1    Storci, G.2    Giovannini, C.3
  • 24
    • 22244467085 scopus 로고    scopus 로고
    • Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner
    • Krysan K, Reckamp KL, Dalwadi H. Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Cancer Res. 2005, 65:6275-81.
    • (2005) Cancer Res. , vol.65 , pp. 6275-6281
    • Krysan, K.1    Reckamp, K.L.2    Dalwadi, H.3
  • 25
    • 33646509029 scopus 로고    scopus 로고
    • RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells
    • Strillacci A, Griffoni C, Spisni E. RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells. Br J Cancer. 2006, 94:1300-10.
    • (2006) Br J Cancer. , vol.94 , pp. 1300-1310
    • Strillacci, A.1    Griffoni, C.2    Spisni, E.3
  • 27
    • 0038118505 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma
    • Chrastina A, Zavada J, Parkkila S. Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma. Int J Cancer. 2003, 105:873-8.
    • (2003) Int J Cancer. , vol.105 , pp. 873-878
    • Chrastina, A.1    Zavada, J.2    Parkkila, S.3
  • 28
    • 0141937204 scopus 로고    scopus 로고
    • Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX
    • Zat'ovicova M, Tarabkova K, Svastova E. Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX. J Immunol Methods. 2003, 282:117-34.
    • (2003) J Immunol Methods. , vol.282 , pp. 117-134
    • Zat'ovicova, M.1    Tarabkova, K.2    Svastova, E.3
  • 29
    • 0028857271 scopus 로고
    • A " quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas
    • Detre S, Saclani Jotti G, Dowsett M. A " quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas. J Clin Pathol. 1995, 48:876-8.
    • (1995) J Clin Pathol. , vol.48 , pp. 876-878
    • Detre, S.1    Saclani Jotti, G.2    Dowsett, M.3
  • 30
    • 0034671307 scopus 로고    scopus 로고
    • Hypoxia-inducible expression of tumor-associated carbonic anhydrases
    • Wykoff CC, Beasley NJ, Watson PH. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res. 2000, 60:7075-83.
    • (2000) Cancer Res. , vol.60 , pp. 7075-7083
    • Wykoff, C.C.1    Beasley, N.J.2    Watson, P.H.3
  • 31
    • 0035947586 scopus 로고    scopus 로고
    • Prostaglandin E2 increases growth and motility of colorectal carcinoma cells
    • Sheng H, Shao J, Washington MK. Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem. 2001, 276:18075-81.
    • (2001) J Biol Chem. , vol.276 , pp. 18075-18081
    • Sheng, H.1    Shao, J.2    Washington, M.K.3
  • 32
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • Saxena NK, Sharma D, Ding X. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res. 2007, 67:2497-507.
    • (2007) Cancer Res. , vol.67 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3
  • 33
    • 33745686438 scopus 로고    scopus 로고
    • Association between cyclooxygenase-2 and matrix metalloproteinase-2 expression in non-small cell lung cancer
    • Byun JH, Lee MA, Roh SY. Association between cyclooxygenase-2 and matrix metalloproteinase-2 expression in non-small cell lung cancer. Jpn J Clin Oncol. 2006, 36:263-8.
    • (2006) Jpn J Clin Oncol. , vol.36 , pp. 263-268
    • Byun, J.H.1    Lee, M.A.2    Roh, S.Y.3
  • 34
    • 33748489508 scopus 로고    scopus 로고
    • H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive, phenotype in rat liver epithelial cells
    • Lee KW, Kim MS, Kang NJ. H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive, phenotype in rat liver epithelial cells. Int J Cancer. 2006, 119:1767-75.
    • (2006) Int J Cancer. , vol.119 , pp. 1767-1775
    • Lee, K.W.1    Kim, M.S.2    Kang, N.J.3
  • 35
    • 8844249356 scopus 로고    scopus 로고
    • Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
    • Svastova E, Hulikova A, Rafajova M. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett. 2004, 577:439-45.
    • (2004) FEBS Lett. , vol.577 , pp. 439-445
    • Svastova, E.1    Hulikova, A.2    Rafajova, M.3
  • 37
    • 33744912284 scopus 로고    scopus 로고
    • Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway
    • Uenoyama Y, Seno H, Fukuda A. Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway. Oncogene. 2006, 25:3277-85.
    • (2006) Oncogene. , vol.25 , pp. 3277-3285
    • Uenoyama, Y.1    Seno, H.2    Fukuda, A.3
  • 38
    • 22844444398 scopus 로고    scopus 로고
    • Methylation of the CA9 promoter can modulate expression of the tumor-associated carbonic anhydrase IX in dense carcinoma cell lines
    • Jakubickova L, Biesova Z, Pastorekova S. Methylation of the CA9 promoter can modulate expression of the tumor-associated carbonic anhydrase IX in dense carcinoma cell lines. Int J Oncol. 2005, 26:1121-7.
    • (2005) Int J Oncol. , vol.26 , pp. 1121-1127
    • Jakubickova, L.1    Biesova, Z.2    Pastorekova, S.3
  • 39
    • 34547138889 scopus 로고    scopus 로고
    • Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer
    • Hilska M, Roberts PJ, Collan YU. Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer. Int J Cancer. 2007, 121:714-23.
    • (2007) Int J Cancer. , vol.121 , pp. 714-723
    • Hilska, M.1    Roberts, P.J.2    Collan, Y.U.3
  • 40
    • 0031819881 scopus 로고    scopus 로고
    • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
    • Saarnio J, Parkkila S, Parkkila AK. Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol. 1998, 153:279-85.
    • (1998) Am J Pathol. , vol.153 , pp. 279-285
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3
  • 41
    • 11144224065 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer
    • Soumaoro LT, Uetake H, Higuchi T. Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. Clin Cancer Res. 2004, 10:8465-71.
    • (2004) Clin Cancer Res. , vol.10 , pp. 8465-8471
    • Soumaoro, L.T.1    Uetake, H.2    Higuchi, T.3
  • 42
    • 34249815207 scopus 로고    scopus 로고
    • Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas
    • Cleven AH, van Engeland M, Wouters BG. Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol. 2007, 29:229-40.
    • (2007) Cell Oncol. , vol.29 , pp. 229-240
    • Cleven, A.H.1    van Engeland, M.2    Wouters, B.G.3
  • 43
    • 26044442817 scopus 로고    scopus 로고
    • Macrophages direct tumour histology and clinical outcome in a colon cancer model
    • Oosterling SJ, van der Bij GJ, Meijer GA. Macrophages direct tumour histology and clinical outcome in a colon cancer model. J Pathol. 2005, 207:147-55.
    • (2005) J Pathol. , vol.207 , pp. 147-155
    • Oosterling, S.J.1    van der Bij, G.J.2    Meijer, G.A.3
  • 44
    • 0036288122 scopus 로고    scopus 로고
    • Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer
    • Petersen VC, Baxter KJ, Love SB. Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer. Gut. 2002, 51:65-9.
    • (2002) Gut. , vol.51 , pp. 65-69
    • Petersen, V.C.1    Baxter, K.J.2    Love, S.B.3
  • 45
    • 34247179157 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 and its inhibition in cancer: is there a role
    • Liao Z, Mason KA, Milas L. Cyclo-oxygenase-2 and its inhibition in cancer: is there a role. Drugs. 2007, 67:821-45.
    • (2007) Drugs. , vol.67 , pp. 821-845
    • Liao, Z.1    Mason, K.A.2    Milas, L.3
  • 46
    • 34247485893 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails
    • Winum JY, Thiry A, Cheikh KE. Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails. Bioorg Med Chem Lett. 2007, 17:2685-91.
    • (2007) Bioorg Med Chem Lett. , vol.17 , pp. 2685-2691
    • Winum, J.Y.1    Thiry, A.2    Cheikh, K.E.3
  • 47
    • 34249736510 scopus 로고    scopus 로고
    • Dual carbonic anhydrase-cyclooxygenase-2 inhibitors
    • Dogne JM, Thiry A, Pratico D. Dual carbonic anhydrase-cyclooxygenase-2 inhibitors. Curr Top Med Chem. 2007, 7:885-91.
    • (2007) Curr Top Med Chem. , vol.7 , pp. 885-891
    • Dogne, J.M.1    Thiry, A.2    Pratico, D.3
  • 48
    • 0033986761 scopus 로고    scopus 로고
    • Causes and consequences of tumour acidity and implications for treatment
    • Stubbs M, McSheehy PM, Griffiths JR. Causes and consequences of tumour acidity and implications for treatment. Mol Med Today. 2000, 6:15-9.
    • (2000) Mol Med Today. , vol.6 , pp. 15-19
    • Stubbs, M.1    McSheehy, P.M.2    Griffiths, J.R.3
  • 49
    • 42549148009 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: a new druggable target for the design of antitumor agents
    • Winum JY, Rami M, Scozzafava A. Carbonic anhydrase IX: a new druggable target for the design of antitumor agents. Med Res Rev. 2008, 28:445-63.
    • (2008) Med Res Rev. , vol.28 , pp. 445-463
    • Winum, J.Y.1    Rami, M.2    Scozzafava, A.3


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