Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 3351-3359

  Lendrihas, Thomas ^a   Hunter, Gregory A ^a   Ferreira, Gloria C ^a,b,c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5-AMINOLEVULINATE; 5-AMINOLEVULINATE SYNTHASE; ACTIVE SITE; CATALYTIC COMPLEXES; CATALYTIC EFFICIENCIES; CATALYZED REACTIONS; COENZYME A; COFACTORS; CONFORMATIONAL EQUILIBRIUM; CONFORMATIONAL TRANSITIONS; ENZYMATIC ACTIVITIES; ENZYME CONFORMATIONS; HEME BIOSYNTHESIS; HYDROGEN BONDINGS; HYDROXYL GROUPS; INDUCED-FIT MECHANISM; MICROENVIRONMENTS; PHENOLIC OXYGEN; PLP-DEPENDENT ENZYMES; PRODUCT RELEASE; PROTEIN FLUORESCENCE; RHODOBACTER CAPSULATUS; SIDE CHAINS; SUBSTRATE-BOUND; SULFUR ATOMS; SYNTHASES; THIOESTERS; TRANSIENT KINETIC ANALYSIS; WILD TYPES; X RAY CRYSTAL STRUCTURES;

AMINO ACIDS; ANIMALS; BIOCHEMISTRY; CARBON DIOXIDE; CIRCULAR DICHROISM SPECTROSCOPY; CRYSTAL ATOMIC STRUCTURE; DICHROISM; ENZYMES; HYDROGEN BONDS; OXYGEN; PHENOLS; PORPHYRINS; SULFUR;

PHOSPHATASES;

5 AMINOLEVULINATE SYNTHASE; ALANINE; GLYCINE; HYDROXYL GROUP; PYRIDOXAL 5 PHOSPHATE; SERINE; SUCCINYL COENZYME A; THREONINE; AMINOLEVULINIC ACID; OXYGEN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; FLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECRETION; ANIMAL; CHEMISTRY; KINETICS; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MOUSE; PROTEIN CONFORMATION; RHODOBACTER CAPSULATUS; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANIMALIA; FUNGI; MURINAE; RHODOBACTER CAPSULATUS;

5-AMINOLEVULINATE SYNTHETASE; AMINO ACID SEQUENCE; AMINOLEVULINIC ACID; ANIMALS; CATALYSIS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; KINETICS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXYGEN; PROTEIN CONFORMATION; RHODOBACTER CAPSULATUS; SERINE;

EID: 77449105229     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.066548     Document Type: Article

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