Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity

Protein Science

Volumn 18, Issue 9, 2009, Pages 1847-1859

  Lendrihas, Thomas ^a   Zhang, Junshun ^a   Hunter, Gregory A ^a   Ferreira, Gloria C ^a,b,c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

oxoamine synthase family; 5 aminolevulinate; 5 aminolevulinate synthase; Heme; Phenolic oxygen; Pyridoxal; Pyridoxal 5 phosphate; Quinonoid intermediate

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; ACYL COENZYME A; AMINO ACID; ARGININE; CARBOXYLIC ACID; LIGAND; SUCCINYL COENZYME A; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CIRCULAR DICHROISM; ENZYME BINDING; ENZYME SPECIFICITY; HYDROPHOBICITY; KINETICS; MICROSCOPY; PRIORITY JOURNAL; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS;

5-AMINOLEVULINATE SYNTHETASE; ACYL COENZYME A; ANIMALS; CIRCULAR DICHROISM; KINETICS; MODELS, MOLECULAR; MURINAE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

MAMMALIA; MURINAE; RHODOBACTER CAPSULATUS;

EID: 69249096519     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.195     Document Type: Article

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