Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans

EMBO Journal

Volumn 24, Issue 18, 2005, Pages 3166-3177

  Astner, Isabel ^a   Schulze, Jörg O ^a   Van Den Heuvel, Joop ^a   Jahn, Dieter ^b   Schubert, Wolf Dieter ^a   Heinz, Dirk W ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Aminolevulinic acid synthase; Bacteriochlorophyll; PLP; Tetrapyrrole biosynthesis; X linked sideroblastic anemia

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; BACTERIAL ENZYME; COENZYME A; DIMER; GLYCINE; HEME; PYRIDOXAL 5 PHOSPHATE; SUCCINYL COENZYME A; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; CRYSTAL STRUCTURE; ENZYME STRUCTURE; FEMALE; GENETIC LINKAGE; HUMAN; MALE; PATHOGENESIS; PRIORITY JOURNAL; RHODOBACTER CAPSULATUS; X LINKED SIDEROBLASTIC ANEMIA;

5-AMINOLEVULINATE SYNTHETASE; ACYL COENZYME A; AMINO ACID SEQUENCE; ANEMIA, SIDEROBLASTIC; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GENETIC DISEASES, X-LINKED; GLYCINE; HEME; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, QUATERNARY; PYRIDOXAL PHOSPHATE; RHODOBACTER CAPSULATUS; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

ALPHAPROTEOBACTERIA; ANIMALIA; EUKARYOTA; RHODOBACTER CAPSULATUS;

EID: 25144499698     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600792     Document Type: Article

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