DNA methylation of multiple promoter-associated CpG islands in meningiomas: Relationship with the allelic status at 1p and 22q

Acta Neuropathologica

Volumn 108, Issue 5, 2004, Pages 413-421

  Bello, M Josefa ^a   Amiñoso, Cinthia ^a   Lopez Marin, Isabel ^a   Arjona, Dolores ^a   Gonzalez Gomez, Pilar ^a   Alonso, M Eva ^a   Lomas, Jesus ^a   de Campos, Jose M ^b   Kusak, M Elena ^b   Vaquero, Jesus ^c   Isla, Alberto ^a   Gutierrez, Manuel ^a   Sarasa, Jose L ^d   Rey, Juan A ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

^c HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^d Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

CpG islands; Meningioma; MGMT; Promoter methylation; THBS1

Indexed keywords

CASPASE 8; DEATH ASSOCIATED PROTEIN KINASE; ESTROGEN RECEPTOR ALPHA; GENOMIC DNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P14; PROTEIN P16; PROTEIN P73; RETINOBLASTOMA PROTEIN; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN TISSUE; CANCER GRADING; CARCINOGENESIS; CHROMOSOME 1P; CHROMOSOME 22Q; CHROMOSOME ABERRATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; FEMALE; GENE DELETION; GENE FREQUENCY; GENE ISOLATION; GENETIC ASSOCIATION; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MENINGIOMA; PRIORITY JOURNAL; PROMOTER REGION; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MENINGEAL NEOPLASMS; MENINGIOMA; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS);

EID: 7744237347     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-004-0911-6     Document Type: Article

References (60)

1. Alonso ME, Bello MJ, Gonzalez-Gomez P, Arjona D, Lomas J, Campos JM de, Isla A, Sarasa JL, Rey JA (2003) Aberrant promoter methylation of multiple genes in oligodendrogliomas and ependymomas. Cancer Genet Cytogenet 144:134-142 10.1016/S0165-4608(02)00928-7, 1:CAS:528:DC%2BD3sXltF2hsbY%3D, 12850376
2. Alonso ME, Bello MJ, Gonzalez-Gomez P, Arjona D, Campos JM de, Gutierrez M, Rey JA (2004) Aberrant CpG island methylaiton of multiple genes in ependymal tumors. J Neurooncol 67:159-165 10.1023/B:NEON.0000021862.41799.f7, 15072463
3. Amatya VJ, Takeshima Y, Inai K (2004) Methylation of p14(ARF) gene in meningiomas and its correlation to the p53 expression and mutation. Mod Pathol 17:705-710
4. Apte SS, Mattei M-G, Olsen BR (1994) Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics 19:86-90 10.1006/geno.1994.1016, 1:CAS:528:DyaK2cXlvFOitbs%3D, 8188246
5. Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR (1999) Methylation-associated silencing of the tissue inhibitor of Metalloproteinase-3 gene suggests a suppressor role in kidney, brain, and other human cancers. Cancer Res 59:798-802 1:CAS:528:DyaK1MXht1SjurY%3D, 10029065
6. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP (1998) Alterations in the DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res 72:141-196 1:CAS:528:DyaK2sXotVyktr8%3D, 9338076
7. Bello MJ, Campos JM de, Kusak ME, Vaquero J, Sarasa JL, Pestaǹa A, Rey JA (1994) Allelic loss at 1p is associated with tumor progression of meningiomas. Genes Chromosomes Cancer 9:296-298
8. Bello MJ, Campos JM de, Vaquero J, Kusak ME, Sarasa JL, Rey JA (2000) High-resolution analysis of chromosome arm 1p alterations in meningioma. Cancer Genet Cytogenet 120:30-36 10.1016/S0165-4608(99)00249-6, 1:CAS:528:DC%2BD3cXksFGjtrs%3D, 10913674
9. Bello MJ, Alonso ME, Amiǹoso C, Anselmo NP, Arjona D, Gonzalez-Gomez P, Lopez-Marin I, Campos JM de, Gutierrez M, Isla A, Kusak ME, Lassaletta L, Sarasa JL, Vaquero J, Casartelli C, Rey JA (2004) Hypermethylation of the DNA repair gene MGMT: Association with TP53 G:C to A:T transitions in a series of 469 nervous system tumors. Mutation Res 554:23-32 10.1016/j.mrfmmm.2004.02.011, 1:CAS:528:DC%2BD2cXmvFyrurw%3D
10. Bostr̈m J, Meyer-Puttlitz B, Wolter M, Blschke B, Weber RG, Lichter P, Ichimura K, Collins VP, Reifenberger G (2001) Alterations of the tumor suppressor genes CDKN2A (p16 INK4a ), p14 ARF , CDKN2B (p15 INK4b ), and CDKN2C (p18 INK4c ) in atypical and anaplastic meningiomas. Am J Pathol 159:661-669 11485924
11. Büschges R, Boström J, Wolter M, Blaschke B, Weber RG, Lichter P, Collins P, Reifenberger G (2001) Analysis of human meningiomas for aberrations of the MADH2, MADH4, APM-1 and DCC tumor suppressor genes on the long arm of chromosome 18. Int J Cancer 92:551-554 10.1002/ijc.1219, 11304690
12. Cai DX, Banerjee R, Scheithauer BW, Lohse CM, Kleinschmidt-Demasters BK, Perry A (2001) Chromosome 1p and 14q FISH analysis in clinicopathologic subsets of meningioma: Diagnostic and prognostic implications. J Neuropathol Exp Neurol 60:628-636
13. Corn PG, Kuerbitz SJ, Noesel MM van, Esteller M, Compitello N, Baylin SB, Herman JG (1999) Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation. Cancer Res 59:3352-3356 1:CAS:528:DyaK1MXks1Oms74%3D, 10416592
14. Costello JF, Plass C, Cavenee W (2000) Aberrant methylation of genes in low-grade astrocytomas. Brain Tumor Pathol 17:49-56 1:CAS:528:DC%2BD3MXit1eqs7w%3D, 11210171
15. Dong S-H, Pang JC-S, Poon W-S, Hu J, To K-F, Chang AR, Ng H-K (2001) Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors. J Neuropathol Exp Neurol 60:808-816 1:CAS:528:DC%2BD3MXmtVGmsrg%3D, 11487055
16. Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN, Issa J-PJ, Sidransky D, Baylin SB, Herman JG (2000) Inactivation of the DNA repair gene O 6 -methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 60:2368-2371 1:CAS:528:DC%2BD3cXjtV2qtro%3D, 10811111
17. Esteller M, Corn PG, Baylin SB, Herman JG (2001) A gene hypermethylation profile of human cancer. Cancer Res 61:3225-3229 1:CAS:528:DC%2BD3MXjtFSjt7g%3D, 11309270
18. Esteller M, Risques R-A, Minoru T, Capella G, Moreno V, Peinado MA, Baylin SH, Herman JG (2001) Promoter hypermethylation of the DNA repair gen O 6 -methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res 61:4689-4692 1:CAS:528:DC%2BD3MXks1GrtLg%3D, 11406538
19. Gonzalez-Gomez P, Bello MJ, Alonso ME, Arjona D, Lomas J, Campos JM de, Isla A, Rey JA (2003) CpG island methylation status and mutation analysis of the RB1 gene essential promoter region and protein-binding pocket domain in nervous system tumours. Br J Cancer 88:109-114 10.1038/sj.bjc.6600737, 1:CAS:528:DC%2BD3sXntFSnsA%3D%3D, 12556968
20. Gonzalez-Gomez P, Bello MJ, Alonso ME, Lomas J, Arjona D, Campos JM de, Vaquero J, Isla A, Lassaletta L, Gutierrez M, Sarasa JL, Rey JA (2003) CpG island methylation in sporadic and neurofibromatosis type 2-associated schwannomas. Clin Cancer Res 9:5601-5606
21. Gonzalez-Gomez P, Bello MJ, Arjona D, Alonso ME, Lomas J, Campos JM de, Kusak ME, Gutierrez M, Sarasa JL, Rey JA (2003) Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas. Oncol Rep 10:1519-1523 1:CAS:528:DC%2BD3sXmvFWns7k%3D, 12883734
22. Gonzalez-Gomez P, Bello MJ, Arjona D, Lomas J, Alonso ME, Campos JM de, Vaquero J, Isla A, Gutierrez M, Rey JA (2003) Promoter hypermethylation of multiple genes in astrocytic gliomas. Int J Oncol 22:601-608 1:CAS:528:DC%2BD3sXhslKru70%3D, 12579314
23. Gonzalez-Gomez P, Bello MJ, Lomas J, Alonso ME, Amiǹoso C, Lopez-Marin I, Anselmo NP, Sarasa JL, Gutierrez M, Casartelli C, Rey JA (2003) Aberrant methylation of multiple genes in neuroblastic tumours: relationship with MYCN amplification and allelic status at 1p. Eur J Cancer 39:1478-1485 10.1016/S0959-8049(03)00312-5, 1:CAS:528:DC%2BD3sXkvVWjsrs%3D, 12826052
24. Herman JG, Graff JR, Myohannen S, Nelkin BD, Baylin BD (1996) Methylation-specific PCR: A novel PCR assay for methylaiton status of CpG islands. Proc Natl Acad Sci USA 93:9821-9826 10.1073/pnas.93.18.9821, 1:CAS:528:DyaK28XlsFeht7Y%3D, 8790415
25. Hong C, Bollen AW, Costello JF (2003) The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas. Cancer Res 63:7600-7605 1:CAS:528:DC%2BD3sXptFOls7o%3D, 14633674
26. Horiguchi K, Tomizawa Y, Tosaka M, Ishiuchi S, Kurihara H, Mori M, Saito N (2003) Epigenetic inactivation of RASSF1A candidate tumor suppressor gene at 3p21.3 in brain tumors. Oncogene 22:7862-7865 10.1038/sj.onc.1207082, 1:CAS:528:DC%2BD3sXosVykurs%3D, 14586413
27. Jiang SY, Jordan VC (1992) Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J Natl Cancer Inst 65:163-168
28. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancer. Cell 90:809-819 10.1016/S0092-8674(00)80540-1, 1:CAS:528:DyaK2sXlvFKmurY%3D, 9288759
29. Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF, Sherr CJ (1998) Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci USA 95:8292-8297 10.1073/pnas.95.14.8292, 1:CAS:528:DyaK1cXks1Slu7g%3D, 9653180
30. Kang GH, Shim Y-H, Jung H-Y, Kim WH, Ro JY, Rhyu M-G (2001) CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res 61:2847-2851 1:CAS:528:DC%2BD3MXivFGru74%3D, 11306456
31. Kino T, Takeshima H, Nakao M, Nishi T, Yamamoto K, Kimura T, Saito Y, Kochi M, Kuratsu J, Saya H, Ushio Y (2001) Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma. Genes Cells 6:441-454 10.1046/j.1365-2443.2001.00432.x, 1:CAS:528:DC%2BD3MXkslWit7s%3D, 11380622
32. Lamszus K, Kluwe L, Matschke J, Meissner H, Laas R, Westphal M (1999) Allelic losses at 1p, 9q, 10q, 14q, and 22q in the progression of aggressive meningiomas and undifferentiated meningeal sarcomas. Cancer Genet Cytogenet 110:103-110 10.1016/S0165-4608(98)00209-X, 1:STN:280:DyaK1M3jtV2ksA%3D%3D, 10214357
33. Leone PE, Bello MJ, Campos JM de, Vaquero J, Sarasa JL, Pestaǹa A, Rey JA (1999) NF2 gene mutations and allelic status of 1p, 14q and 22q in sporadic meningiomas. Oncogene 18:2231-2239 10.1038/sj.onc.1202531, 1:CAS:528:DyaK1MXis12murg%3D, 10327069
34. Li Q, Ahuja N, Burger PC, Issa J-PJ (1999) Methylation and silencing of the thrombospondin-1 promoter in human cancer. Oncogene 18:3284-3289 10.1038/sj.onc.1202663, 1:CAS:528:DyaK1MXjvVeqs7s%3D, 10359534
35. Lindblom A, Ruttledge M, Collins VP, Nordenskjold M, Dumanski JP (1994) Chromosomal deletions in anaplastic meningiomas suggest multiple regions outside chromosome 22 as important in tumor progression. Int J Cancer 56:354-357 1:STN:280:ByuC2cfltl0%3D, 8314321
36. Lomas J, Amiǹoso C, Gonzalez-Gomez P, Alonso ME, Arjona D, Lopez-Marin I, Campos JM de, Isla A, Vaquero J, Gutierrez M, Sarasa JL, Bello MJ, Rey JA (2004) Methylation status of TP73 in meningiomas. Cancer Genet Cytogenet 148:148-151 10.1016/S0165-4608(03)00244-9, 1:CAS:528:DC%2BD2cXltVKhtQ%3D%3D, 14734228
37. Lopez-Gines C, Cerda-Nicolas M, Gil-Benso R, Callaghan R, Collado M, Roldan P, Llombart-Bosch A (2004) Association of loss of 1p and alterations of chromosome 14 in meningioma progression. Cancer Genet Cytogenet 148:123-128 10.1016/S0165-4608(03)00279-6, 1:CAS:528:DC%2BD2cXltVKhsw%3D%3D, 14734222
38. Louis DN, Scheithauer BW, Budka H, Deimling A von, Kepes JJ (2000) Meningioma. Kleihues P, Cavenee WK (eds) Pathology and genetics. Tumours of the nervous system. World Health Organization classification of tumours. IARC Press, Lyon, 176-184 Kleihues P, Cavenee WK (eds) World Health Organization classification of tumours. IARC Press, Lyon
39. Mihaila D, Gutierrez JA, Rosemblum ML, Newsham IF, Bogler O, Rempel SA (2003) Meningiomas: Analysis of loss of heterozygosity on chromosome 10 in tumor progression and the delineation of four regions of chromosomal deletion in common with other cancers. Clin Cancer Res 9:4435-4442
40. Murakami M, Hashimoto N, Takahashi Y, Hosokawa Y, Inazawa J, Mineura K (2003) A consistent region of deletion on 1p36 in meningiomas: identification and relation to malignant progression. Cancer Genet Cytogenet 140:99-106 10.1016/S0165-4608(02)00653-2, 1:CAS:528:DC%2BD3sXhslKhtr8%3D, 12645646
41. Nakamura M, Watanabe T, Yonekawa Y, Kleihues P, Ohgaki H (2001) Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C to A:T mutations of the TP53 tumor suppressor gene. Carcinogenesis 22:1715-1719 10.1093/carcin/22.10.1715, 1:CAS:528:DC%2BD3MXnsFKmtbc%3D, 11577014
42. Nakamura M, Yonekawa Y, Kleihues P, Ohgaki H (2001) Promoter hypermethylation of the RB1 gene in glioblastomas. Lab Invest 81:77-82 1:CAS:528:DC%2BD3MXht1Sht7w%3D, 11204276
43. Natarajan AT, Vermeulen S, Darroudi F, Valentine MB, Brent TP, Mitra S, Tano K (1992) Chromosomal localization of human O(6)-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization. Mutagenesis 7:83-85 1:CAS:528:DyaK38Xit12gs7s%3D, 1635460
44. Pegg AE (1990) Mammalian O 6 -alkylguanine-DNA alkyltransferase regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res 50:6119-6129 1:CAS:528:DyaK3cXmtVOisLs%3D, 2205376
45. Powe DG, Brough JL, Carter GI, Bailey EM, Stetler-Stevenson WG, Turner DR, Hewitt RE (1997) TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma. Br J Cancer 75:1678-1683 1:CAS:528:DyaK2sXkt1Ontrc%3D, 9184186
46. Rempel SA, Schwechheimer K, Davis RL, Cavenee WK, Rosemblum, ML (1993) Loss of heterozygosity for loci on chromosme 10 is associated with morphologically malignant meningioma progression. Cancer Res 53:2386-2392 1:STN:280:ByyB2M7ks1M%3D, 8485725
47. Ruttledge MH, Sarrazin J, Rangaratnam S, Phelan CM, Twist P, Merel P, Delattre O, Thomas G, Nordenskjold M, Collins VP, Dumanski JP, Rouleau GA (1994) Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nat Genet 6:180-184 10.1038/ng0294-180, 1:CAS:528:DyaK2cXhs1SgtrY%3D, 8162072
48. Simon M, Deimling A von, Larson JJ, Wellenreuther R, Kaskel P, Waha A, Warnick RE, Tew JM, Menon AG (1995) Allelic losses on chromosome 14, 10, and 1 in atypical and malignant meningiomas. A genetic model of meningioma progression. Cancer Res 55:4696-4701 1:CAS:528:DyaK2MXoslWmsbk%3D, 7553651
49. Simpson DJ, Hibberts NA, McNicol AM, Clayton RN, Farrell WE (2000) Loss of pRB expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Res 60:1211-1216 1:CAS:528:DC%2BD3cXhvFWrsbg%3D, 10728677
50. Sherr CJ (1996) Cancer cell cycles. Science 274:1672-1677 10.1126/science.274.5293.1672, 1:CAS:528:DyaK28XntlyktLs%3D, 8939849
51. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ (2000) Caspase 8 is deleted or silenced preferentially in childhood neuroblastoams with amplification of MYCN. Nat Med 6:529-535 10.1038/75007, 1:CAS:528:DC%2BD3cXjtFyhsLs%3D, 10802708
52. Tse JY, Ng HK, Lo KW, Lam PY, Ng EK, Poon WS, Huang DP (1998) Analysis of cell cycle regulators: P16INK4A, pRb, and CDK4 in low- and high-grade meningiomas. Hum Pathol 29:1200-1207 10.1016/S0046-8177(98)90246-5, 1:CAS:528:DyaK1cXotVagu78%3D, 9824096
53. Uhlmann K, Rohde K, Zeller C, Szymas J, Vogel S, Marczinek K, Thiel G, Nùrnberg P, Laird PW (2003) Distinct methylaiton profiles of glioma subtypes. Int J Cancer 106:52-59 10.1002/ijc.11175, 1:CAS:528:DC%2BD3sXltFent7Y%3D, 12794756
54. Watanabe T, Nakamura M, Yonekawa Y, Kleihues P, Ohgaki H (2001) Promoter hypermethylation and homozygous deletion of the p14 ARF and p16 INK4a genes in oligodendrogliomas. Acta Neuropathol 101:185-189 1:CAS:528:DC%2BD3MXht1ejsrc%3D, 11307615
55. Weber RG, Boström J, Wolter M, Baudis M, Collins VP, Reifenberger G, Lichter P (1997) Analysis of geneomic alterations in benign, atypical, and anaplastic meningiomas. Toward a genetic model of meningioma progression. Proc Natl Acad Sci USA 94:14719-14724 10.1073/pnas.94.26.14719, 1:CAS:528:DyaK1cXis1OltQ%3D%3D, 9405679
56. Wolter M, Reifenberger J, Blaschke B, Ichimura K, Schmidt EE, Collins VP, Reifenberger G (2001) Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16 INK4a ), p14 ARF , and CDKN2B (MTS2, p15 INK4b ) tumor suppressor genes. J Neuropathol Exp Neurol 60:1170-1180 1:CAS:528:DC%2BD38XitFelsg%3D%3D, 11764089
57. Xing EP, Nie Y, Song Y, Yang G-Y, Cai YC, Wang LD, Yang CS (1999) Mechanisms of inactivation of p14 ARF , p15 INK4b , and p16 INK4a genes in human esophageal squamous cell carcinoma. Clin Cancer Res 5:2704-2713
58. Yin D, Xie D, Hofmann W-K, Miller CW, Black KL, Koeffler HP (2002) Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors. Oncogene 21:8372-8378 10.1038/sj.onc.1206031, 1:CAS:528:DC%2BD38XovVGms78%3D, 12447702
59. Yin D, Xie D, Hofmann W-K, Zhang W, Asotra K, Wong R, Black KL, Koeffler HP (2003) DNA repair gene O 6 -methylguanine-DNA methyltransferase: promoter hypermethylation associated with decreased expression and G:C to A:T mutations of p53 in brain tumors. Mol Carcinogenesis 36:23-31 10.1002/mc.10094, 1:CAS:528:DC%2BD3sXktlKrsg%3D%3D
60. Zöchbauer-Müller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, Minna JD (2001) Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 61:249-255 11196170