Alterations of the tumor suppressor genes CDKN2A (p16INK4a), p14ARF, CDKN2B (p15INK4b), and CDKN2C (p18INK4c) in atypical and anaplastic meningiomas

American Journal of Pathology

Volumn 159, Issue 2, 2001, Pages 661-669

  Boström, Jan ^a   Meyer Puttlitz, Birgit ^a   Wolter, Marietta ^b   Blaschke, Britta ^b   Weber, Ruthild G ^c   Lichter, Peter ^d   Ichimura, Koichi ^e   Collins, V Peter ^e   Reifenberger, Guido ^b  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ANAPLASTIC CARCINOMA; ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; GENE DOSAGE; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MENINGIOMA; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

EID: 0034884392     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61737-3     Document Type: Article

References (46)

1. Meningiomas
2. "Malignancy" in meningiomas: A clinicopathologic study of 116 patients, with grading implications
3. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma
4. Molecular genetic approach to human meningioma: Loss of genes on chromosome 22
5. Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas
6. Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas
7. Analysis of the neurofibromatosis type 2 gene reveals molecular variants of meningioma
8. Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: Toward a genetic model of meningioma progression
9. INK4a/CDKN2A tumor suppressor and its relatives
10. The p53 pathway
11. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer
12. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
13. Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors
14. INK4a, MTS1) and CDK4 gene have frequent mutations of the retinoblastoma gene
15. Deletion mapping of the short arm of chromosome 1 identifies a common region of deletion distal to D1S496 in human meningiomas
16. Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression
17. Chordoid glioma of the third ventricle: Immunohistochemical and molecular genetic characterization of a novel tumor entity
18. Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas
19. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
20. Cytogenetic changes in 67 cranial and spinal meningiomas: Relation to histopathological and clinical pattern
21. Cytogenetic, molecular genetic and pathological analyses in 126 meningiomas
22. Allelic loss at 1p is associated with tumor progression of meningiomas
23. Chromosomal deletions in anaplastic meningiomas suggest multiple regions outside chromosome 22 as important in tumor progression
24. Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas: A genetic model of meningioma progression
25. Deletion of chromosome 1p and loss of expression of alkaline phosphatase indicate progression of meningiomas
26. Genomic instability in 1p and human malignancies
27. Identification of a consistent region of allelic loss on 1p32 in meningiomas: Correlation with increased morbidity
28. Search for mutations of the hRAD54 gene in sporadic meningiomas with deletion at 1p32
29. INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
30. Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias
31. INK4C genes in multiple myeloma
32. INK4 mutations
33. INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6
34. INK4C gene in human meningiomas
35. Homozygous deletions of the CDKN2/p16 gene in dural hemangiopericytomas
36. Infrequent alterations of the p15, p16, CDK4 and cyclin D1 genes in non-astrocytic human brain tumors
37. INK4A, pRb, and CDK4 in low- and high-grade meningiomas
38. INK4A determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4
39. Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule
40. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
41. ARF tumour suppressor mediate nucleolar localization
42. Alterations in DNA methylation: A fundamental aspect of neoplasia
43. Detection of gains and losses in 18 meningiomas by comparative genomic hybridization
44. Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system
45. Accumulation of wild-type p53 in meningiomas
46. Detection of TP53 gene mutation in human meningiomas: A study using immunohistochemistry, PCR/single-strand conformation polymorphism and DNA sequencing techniques on paraffin-embedded samples