Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma

Genes to Cells

Volumn 6, Issue 5, 2001, Pages 441-454

  Kino, Takeshi ^a   Takeshima, Hideo ^b   Nakao, Mitsuyoshi ^a   Nishi, Toru ^a   Yamamoto, Keizo ^a   Kimura, Takahiro ^a   Saito, Yoshiki ^a   Kochi, Masato ^a   Kuratsu, Jun Ichi ^b   Saya, Hideyuki ^a   Ushio, Yukitaka ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; LUCIFERASE; MESSENGER RNA; NUCLEAR PROTEIN;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; BASE PAIRING; BINDING AFFINITY; CONTROLLED STUDY; CPG ISLAND; ENZYME ASSAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE LOSS; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METHYLATION; MOLECULAR CLONING; NEURILEMOMA; NEUROFIBROMATOSIS; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; RNA TRANSLATION; SITE DIRECTED MUTAGENESIS; TRANSLATION INITIATION;

ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; BRAIN NEOPLASMS; CLONING, MOLECULAR; CPG ISLANDS; DNA METHYLATION; GENE SILENCING; GENES, NEUROFIBROMATOSIS 2; GENES, REPORTER; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEURILEMMOMA; PROMOTER REGIONS (GENETICS); RATS; TRANSFECTION;

EID: 6644226164     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2001.00432.x     Document Type: Article

References (26)

1. Bergman, Y. & Mostoslavsky R. (1998) DNA demethylation: turning genes on. Biol. Chem. 379, 401-407.
2. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
3. De Vitis, L.R., Tedde, A., Vitelli, F., et al. (1996) Screening for mutations in the neurofibromatosis type 2 (NF2) gene in sporadic meningiomas. Hum. Genet. 97, 632-637.
4. Eldridge, R. (1981) Central neurofibromatosis with bilateral acoustic neuroma. Adv. Neurol. 29, 57-65.
5. Fujita, N., Takebayashi, S., Okumura, K., et al. (1999) Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms. Mol. Cell. Biol. 19, 6415-6426.
6. Gregor, V., Passarge, E., Hopping, W., Messmer, B. & Horsthemke, B. (1988) Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum. Genet. 83, 155-158.
7. Harbour, J.W. (1998) Overview of RB gene mutations in patients with retinoblastoma. Implications for clinical genetic screening. Ophthalmology 105, 1442-1447.
8. Herman, J.G., Latif, F., Weng, Y., et al. (1994) Silencing of the VHL tumor suppressor gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. USA 91, 9700-9704.
9. Iguchi, A.S. & Schaffner, W. (1989) CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes Dev. 3, 612-619.
10. Iravani, M., Dhat, R. & Price, C.M. (1997) Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia. Oncogene 15, 2609-2614.
11. Jacoby L.B., MacCollin, M., Barone, R., Ramesh, V. & Gusella, J.F. (1996) Frequency and distribution of NF2 mutations in schwannomas. Genes Chromosomes Cancer 17, 45-55.
12. Jacoby, L.B., MacCollin, M., Louis, D.N., et al. (1994) Exon scanning for mutation of the NF2 gene in schwannomas Hum. Mol. Genet. 3, 413-419.
13. Lobanenkov, V.V., Nicolas, R.H., Adler, V.V, et al. (1990) A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5′-flanking sequence of the chicken c-myc gene. Oncogene 5, 1743-1753.
14. Mancini, D.N., Rodenhiser, D.I., Ainsworth, P.J., et al. (1998) CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site. Oncogene 16, 1161-1169.
15. Mancini, D.N., Singh, S.M., Archer, T.K. & Rodenhiser, D.I. (1999) Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors. Oncogene 18, 4108-4119.
16. Merel, P., Khe, H.X., Sanson, M., et al. (1995) Screening for germ-line mutations in the NF2 gene. Genes Chromosomes Cancer 12, 117-127.
17. Merlo, A., Herman, J.G., Mao, L., et al. (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDK2/MTS1 in human cancers. Nature Med. 1, 686-692.
18. Quandt, K., Frech, K., Karas, H., Wingender, E. & Werner, T. (1995) MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucl. Acids Res. 23, 4878-4884.
19. Rouleau, G.A., Merel, P., Lutchman, M., et al. (1993) Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature 363, 515-521.
20. Sainz, J., Figueroa, K., Baser, M.E. & Pulst, S.M. (1996) Identification of three neurofibromatosis type 2 (NF2) gene mutations in vestibular schwannomas. Hum. Genet. 97, 121-123.
21. Sainz, J., Huynh, D.P., Figueroa, K., Ragge, N.K., Baser, M.E. & Pulst, S.M. (1994) Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas. Hum. Mol. Genet. 3, 885-891.
22. Takeshima, H., Izawa, I., Lee, P.S., Safdar, N., Levin, V.A. & Saya, H. (1994) Detection of cellular proteins that interact with the NF2 tumor suppressor gene product. Oncogene 9, 2135-2144.
23. Takeshima, H., Joh, T., Tsuzuki, T., Shimada, K. & Matsukado, Y. (1988) Structural organization of the mouse mitochondrial malate dehydrogenase gene. J. Mol. Biol. 200, 1-11.
24. Tiemeier, D.C., Tilghman, S.M. & Leder, P. (1977) Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene 2, 173-191.
25. Yamamoto, K., Takeshima, H., Hamada, K., et al. (1999) Cloning and functional characterization of the 5′-flanking region of the human monocyte chemoattractant protein-1 receptor (CCR2) gene. J. Biol. Chem. 274, 4646-4654.
26. Yoshiura, K., Kanai, Y., Ochiai, A., Shimoyama, Y., Sugimura, T. & Hirohashi, S. (1995) Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. USA 92, 7416-7419.