Extracellular matrix-Induced gene expression in human breast cancer cells

Molecular Cancer Research

Volumn 7, Issue 3, 2009, Pages 319-329

  Garamszegi, Nandor ^a,b   Garamszegi, Susanna P ^a   Shehadeh, Lina A ^b   Scully, Sean P ^a,b  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; FIBRONECTIN; INTEGRIN RECEPTOR; LAMININ; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1; VERY LATE ACTIVATION ANTIGEN 2;

ARTICLE; AUTOCRINE EFFECT; BREAST CANCER; CELL ADHESION; CELL COMMUNICATION; CELL NUCLEUS; CELL STRAIN MCF 7; CELL TYPE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FOCAL ADHESION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METASTASIS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; COLLAGEN TYPE I; COLLAGEN TYPE II; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN ALPHA2BETA1; LAMININ; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 62549136078     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0227     Document Type: Article

References (48)

1. Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 2002;70:537-46.
2. Fata JE, Werb Z, Bissell MJ. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res 2004;6:1 -11.
3. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006;6:392 -401.
4. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-54.
5. Atley LM, Mort JS, Lalumiere M, Eyre DR. Proteolysis of human bone collagen by cathepsin K: characterization of the cleavage sites generating by cross-linked N-telopeptide neoepitope. Bone 2000;26:241-7.
6. Downs JT, Lane CL, Nestor NB, et al. Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA. J Immunol Methods 2001;247: 25-34.
7. Li WW, Nemirovskiy O, Fountain S, Rodney Mathews W, Szekely-Klepser G. Clinical validation of an immunoaffinity LC-MS/MS assay for the quantification of a collagen type II neoepitope peptide: a biomarker of matrix metalloproteinase activity and osteoarthritis in human urine. Anal Biochem 2007;369:41-53.
8. Otterness IG, Downs JT, Lane C, et al. Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody. Matrix Biol 1999;18:331-41.
9. Buzza MS, Zamurs L, Sun J, et al. Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin, J Biol Chem 2005;280:23549-58.
10. Chang C, Lauffenburger DA, Morales TI. Motile chondrocytes from newborn calf: migration properties and synthesis of collagen II. Osteoarthritis Cartilage 2003; 1L603 - 12.
11. Kenny HA, Kaur S, Coussens LM, Lengyel E. The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. J Clin Invest 2008;118:1367-79.
12. Koshikawa N, Schenk S, Moeckel G, et al. Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. FASEB J 2004;18:364-6.
13. Midwood KS, Mao Y, Hsia HC, Valenick LV, Schwarzbauer JE. Modulation of cell-fibronectin matrix interactions during tissue repair. J Investig Dermatol Symp Proc 2006;11:73-8.
14. Pilcher BK, Dumin JA, Sudbeck BD, Krane SM, Welgus FIG, Parks WC. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix. J Cell Biol 1997;137:1445-57.
15. Remy L, Trespeuch C, Bachy S, Scoazec JY, Rousselle P. Matrilysin 1 influences colon carcinoma cell migration by cleavage of the laminin-5 03 chain. Cancer Res 2006:66:11228-37.
16. Steadman R. Irwin MH, St John PL, Blackburn WD, Heck LW, Abrahamson DR. Laminin cleavage by activated human neutrophils yields proteolytic fragments with selective migratory properties. J Leukoc Biol 1993;53:354-65.
17. Lamouille S, Derynck R. Cell size and invasion in TGF-β-induced epithelia to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 2007;178:437-51.
18. 1. Mol Biol Cell 1998;9:2627-38.
19. 6 binds and activates latent TGFβl: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999:96:319-28.
20. Sheppard D. Integrin-mediated activation of transforming growth factor-β(l) in pulmonary fibrosis. Chest 2001;120:49 - 53S.
21. Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat Cell Biol 2003;5: 410-21.
22. Attisano L, Wrana JL. Signal transduction by the TGF-β superfamily. Science 2002;296:1646 - 7.
23. Dore JJ, Jr., Yao D, Edens M, Garamszegi N, Sholl EL, Leof EB. Mechanisms of transforming growth factor-β receptor endocytosis and intracellular sorting differ between fibroblasts and epithelial cells. Mol Biol Cell 2001:12:675-84.
24. Garamszegi N, Dore JJ, Jr., Penheiter SG, Edens M, Yao D, Leof EB. Transforming growth factor β receptor signaling and endocytosis are linked through a COOH terminal activation motif in the type I receptor. Mol Biol Cell 2001;12:2881-93.
25. Penheiter SG, Mitchell H, Garamszegi N, Edens M, Dore JJ, Jr., Leof EB. Internalization-dependent and -independent requirements for transforming growth factor β receptor signaling via the Smad pathway. Mol Cell Biol 2002;22:4750-9.
26. Massague J. TGFβ in cancer. Cell 2008;134:215-30.
27. Derynck R, Zhang YE, Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003;425:577-84.
28. Massague J, Chen YG. Controlling TGF-β3 signaling. Genes Dev 2000; 14: 627-44.
29. Inman GJ, Nicolas FJ, Callahan JF, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002;62:65-74.
30. Schneiderbauer MM, Dutton CM, Scully SP. Signaling "cross-talk" between TGF-β1 and ECM signals in chondrocytic cells. Cell Signal 2004;16:1133-40.
31. Wang W, Huang XR, Canlas E, et al. Essential role of Smad3 in angiotensin II-induced vascular fibrosis [see comment]. Circ Res 2006;98:1032 - 9.
32. Moustakas A, Pardali K, Gaal A, Fleldin CH. Mechanisms of TGF-β signaling in regulation of cell growth and differentiation. Immunol Lett 2002;82: 85-91.
33. Muraoka RS, Dumont N, Ritter CA, et al. Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 2002;109: 1551-9.
34. Bissell MJ, Kenny PA, Radisky DC. Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb Symp Quant Biol 2005;70:343-56.
35. Kenny PA, Lee GY, Bissell MJ. Targeting the tumor microenvironment. Front Biosci 2007;12:3468-74.
36. LaBarge MA, Petersen OW, Bissell MJ, Of microenvironments and mammary stem cells. Stem Cell Rev 2007;3:137-46.
37. Lee GY, Kenny PA, Lee EH, Bissell MJ. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 2007;4:359-65.
38. Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003;30:256-68.
39. Comoglio PM, Boccaccio C, Trusolino L. Interactions between growth factor receptors and adhesion molecules: breaking the rules. Curr Opin Cell Biol 2003; 15:565-71.
40. Geiger B, Bershadsky A. Assembly and mechanosensory function of focal contacts. Curr Opin Cell Biol 2001;13:584-92.
41. Shi Y. Massague J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
42. Vilar JM, Jansen R, Sander C. Signal processing in the TGF-β superfamily ligand-receptor network. PLoS Comput Biol 2006;2:e3.
43. Plow EF, Haas TA, Zhang L, Loftus J, Smith JW. Ligand binding to integrins. J Biol Chem 2000;275:21785-8.
44. 1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines. Br J Cancer 2006; 94:1311-9.
45. Debnath J, Brugge JS. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 2005;5:675-88.
46. ten Dijke P, Arthur HM. Extracellular control of TGFβ signalling in vascular development and disease. Nat Rev Mol Cell Biol 2007;8:857-69.
47. Alcorn JF, Guala AS, van der Velden J, et al. Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-β1. J Cell Sci 2008;121:1036-45.
48. Song J. EMT or apoptosis: a decision for TGF-β. Cell Res 2007;17:289-90.