Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-d-aspartate receptor-triggered neurotoxicity

Neuroscience

Volumn 166, Issue 4, 2010, Pages 1083-1090

  Zhang, M ^a   Xu, J T ^b   Zhu, X ^a   Wang, Z ^a   Zhao, X ^b   Hua, Z ^c   Tao, Y X ^b,c   Xu, Y ^a,c  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NANJING UNIVERSITY   (China)

Author keywords

Ca2+ loading; N methyl d aspartate receptors; neuronal nitric oxide synthase; PSD 93

Indexed keywords

CALCIUM ION; CYCLIC GMP; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NITRIC OXIDE; POSTSYNAPTIC DENSITY 93 PROTEIN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN DISEASE; BRAIN ISCHEMIA; CONTROLLED STUDY; GENE DISRUPTION; MOUSE; NERVE CELL; NERVE CELL LESION; NERVE CELL STIMULATION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SEIZURE; SIGNAL TRANSDUCTION; SYNAPTOSOME; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN DISEASES, METABOLIC; CALCIUM SIGNALING; CELLS, CULTURED; CYCLIC GMP; EXCITATORY AMINO ACID AGONISTS; GENE TARGETING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE DEGENERATION; NEUROTOXINS; NITRIC OXIDE; PRESYNAPTIC TERMINALS; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 77349097080     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.01.030     Document Type: Article

References (36)

1. Aarts M., Liu Y.T., Liu L.D., Besshoh S., Arundine M., Gurd J.W., Wang Y.T., Salter M.W., and Tymianski M. Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science 298 (2002) 846-850
2. Aarts M.M., and Tymianski M. Molecular mechanisms underlying specificity of excitotoxic signaling in neurons. Curr Mol Med 4 (2004) 137-147
3. Arundine M., and Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 34 (2003) 325-337
4. Brenman J.E., Christopherson K.S., Craven S.E., McGee A.W., and Bredt D.S. Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein. J Neurosci 16 (1996) 7407-7415
5. Burnashev N., Schoepfer R., Monyer H., Ruppersberg J.P., Gunther W., Seeburg P.H., and Sakmann B. Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science 257 (1992) 1415-1419
6. Cao J., Viholainen J.I., Dart C., Warwick H.K., Leyland M.L., and Courtney M.J. The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. J Cell Biol 168 (2005) 117-126
7. Carroll R.C., and Zukin R.S. NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 25 (2002) 571-577
8. Cui H., Hayashi A., Sun H.S., Belmares M.P., Cobey C., Phan T., Schweizer J., Salter M.W., Wang Y.T., Tasker R.A., et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci 27 (2007) 9901-9915
9. Czyz A., Baranauskas G., and Kiedrowski L. Instrumental role of Na+ in NMDA excitotoxicity in glucose-deprived and depolarized cerebellar granule cells. J Neurochem 81 (2002) 379-389
10. Dawson V.L., Kizushi V.M., Huang P.L., Snyder S.H., and Dawson T.M. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J Neurosci 16 (1996) 2479-2487
11. de Bartolomeis A., and Fiore G. Postsynaptic density scaffolding proteins at excitatory synapse and disorders of synaptic plasticity: implications for human behavior pathologies. Int Rev Neurobiol 59 (2004) 221-254
12. Elias G.M., Elias L.A., Apostolides P.F., Kriegstein A.R., and Nicoll R.A. Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development. Proc Natl Acad Sci U S A 105 (2008) 20953-20958
13. Gardoni F., Bellone C., Viviani B., Marinovich M., Meli E., Pellegrini-Giampietro D.E., Cattabeni F., and Di Luca M. Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII transduction pathway. Eur J Neurosci 16 (2002) 777-786
14. Girouard H., Wang G., Gallo E.F., Anrather J., Zhou P., Pickel V.M., and Iadecola C. NMDA receptor activation increases free radical production through nitric oxide and NOX2. J Neurosci 29 (2009) 2545-2552
15. Hazell A.S. Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies. Neurochem Int 50 (2007) 941-953
16. Hou X.Y., Zhang G.Y., Wang D.G., Guan Q.H., and Yan J.Z. Suppression of postsynaptic density protein 95 by antisense oligonucleotides diminishes post-ischemic pyramidal cell death in rat hippocampal CA1 subfield. Neurosci Lett 385 (2005) 230-233
17. Jiang S.X., Lertvorachon J., Hou S.T., Konishi Y., Webster J., Mealing G., Brunette E., Tauskela J., and Preston E. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem 280 (2005) 33811-33818
18. Kanada A., Nishimura Y., Yamaguchi J.Y., Kobayashi M., Mishima K., Horimoto K., Kanemaru K., and Oyama Y. Extract of Ginkgo biloba leaves attenuates kainate-induced increase in intracellular Ca2+ concentration of rat cerebellar granule neurons. Biol Pharm Bull 28 (2005) 934-936
19. Kim E., Cho K.O., Rothschild A., and Sheng M. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron 17 (1996) 103-113
20. Liaw W.J., Zhu X.G., Yaster M., Johns R.A., Gauda E.B., and Tao Y.X. Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density 93 protein. Mol Pain 4 (2008) 45
21. Liu Y., Wong T.P., Aarts M., Rooyakkers A., Liu L., Lai T.W., Wu D.C., Lu J., Tymianski M., Craig A.M., et al. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 27 (2007) 2846-2857
22. Lu Y.M., Yin H.Z., Chiang J., and Weiss J.H. Ca(2+)-permeable AMPA/kainate and NMDA channels: high rate of Ca2+ influx underlies potent induction of injury. J Neurosci 16 (1996) 5457-5465
23. McCollum A.T., Nasr P., and Estus S. Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death. J Neurochem 82 (2002) 1208-1220
24. McGee A.W., Topinka J.R., Hashimoto K., Petralia R.S., Kakizawa S., Kauer F., Aguilera-Moreno A., Wenthold R.J., Kano M., and Bredt D.S. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum. J Neurosci 21 (2001) 3085-3091
25. Mehta S.L., Manhas N., and Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev 54 (2007) 34-66
26. Roche K.W., Standley S., McCallum J., Dune Ly C., Ehlers M.D., and Wenthold R.J. Molecular determinants of NMDA receptor internalization. Nat Neurosci 4 8 (2001) 794-802
27. Sans N., Wang P.Y., Du Q., Petralia R.S., Wang Y.X., Nakka S., Blumer J.B., Macara I.G., and Wenthold R.J. mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression. Nat Cell Biol 7 (2005) 1179-1190
28. Sattler R., Xiang Z.G., Lu W.Y., Hafner M., MacDonald J.F., and Tymianski M. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284 (1999) 1845-1848
29. Soriano F.X., Martel M.A., Papadia S., Vaslin A., Baxter P., Rickman C., Forder J., Tymianski M., Duncan R., Aarts M., et al. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. J Neurosci 28 (2008) 10696-10710
30. Tao F., Tao Y.X., Mao P., Zhao C., Li D., Liaw W.J., Raja S.N., and Johns R.A. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience 120 (2003) 847-854
31. Tao Y.X., and Johns R.A. PDZ domains at excitatory synapses: potential molecular targets for persistent pain treatment. Curr Neuropharmacol 4 (2006) 217-223
32. Tao Y.X., and Raja S.N. Are synaptic MAGUK proteins involved in chronic pain?. Trends Pharmacol Sci 25 (2004) 397-400
33. von Engelhardt J., Coserea I., Pawlak V., Fuchs E.C., Kohr G., Seeburg P.H., and Monyer H. Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors. Neuropharmacology 53 (2007) 10-17
34. Watanabe Y., Song T., Sugimoto K., Horii M., Araki N., Tokumitsu H., Tezuka T., Yamamoto T., and Tokuda M. Post-synaptic density 95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Biochem J 372 (2003) 465-471
35. Xu Y., and Tao Y.X. Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. Neuroreport 15 (2004) 263-266
36. Xu Y., Zhang B., Hua Z., Johns R.A., Bredt D.S., and Tao Y.X. Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons. Exp Neurol 189 (2004) 16-24