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Volumn 30, Issue 1, 2010, Pages 75-86

Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma

Author keywords

Benign tumor; Beta catenin; Gene mutation; Genomic; Gp130; Hepatocellular adenoma; Hepatocellular carcinoma; Malignant transformation; MiRNA; Oncogene; Stat3; TP53; Transcriptome; Tumor suppressor gene

Indexed keywords

BETA CATENIN; CATENIN; GLYCOPROTEIN GP 130; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; MICRORNA; TRANSCRIPTOME; WNT PROTEIN;

EID: 77349085585     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0030-1247134     Document Type: Review
Times cited : (75)

References (120)
  • 1
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • Parkin D M. Global cancer statistics in the year 2000. Lancet Oncol 2001 2 (9) 533-543
    • (2001) Lancet Oncol , vol.2 , Issue.9 , pp. 533-543
    • Parkin, D.M.1
  • 2
    • 7044231396 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Recent trends in the United States
    • El-Serag H B. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 2004 127 (5, Suppl 1) S27-S34
    • (2004) Gastroenterology , vol.127 , Issue.5 SUPPL. 1
    • El-Serag, H.B.1
  • 3
    • 14744291909 scopus 로고    scopus 로고
    • Epidemiology and natural history of hepatocellular carcinoma
    • McGlynn K A., London W T. Epidemiology and natural history of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol 2005 19 (1) 3-23
    • (2005) Best Pract Res Clin Gastroenterol , vol.19 , Issue.1 , pp. 3-23
    • McGlynn, K.A.1    London, W.T.2
  • 4
    • 20344392430 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology, risk factors, and screening
    • Sherman M. Hepatocellular carcinoma: epidemiology, risk factors, and screening. Semin Liver Dis 2005 25 (2) 143-154
    • (2005) Semin Liver Dis , vol.25 , Issue.2 , pp. 143-154
    • Sherman, M.1
  • 6
    • 33745570822 scopus 로고    scopus 로고
    • Southern Europe as an example of interaction between various environmental factors: A systematic review of the epidemiologic evidence
    • Donato F, Gelatti U, Limina R M., Fattovich G. Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence. Oncogene 2006 25 (27) 3756-3770
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3756-3770
    • Donato, F.1    Gelatti, U.2    Limina, R.M.3    Fattovich, G.4
  • 7
    • 33745521748 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity
    • Seeff L B., Hoofnagle J H. Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity. Oncogene 2006 25 (27) 3771-3777
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3771-3777
    • Seeff, L.B.1    Hoofnagle, J.H.2
  • 8
    • 0033852937 scopus 로고    scopus 로고
    • Hepatocellular carcinoma occurring in nonfibrotic liver: Epidemiologic and histopathologic analysis of 80 French cases
    • Bralet M P., Régimbeau J M., Pineau P et al. Hepatocellular carcinoma occurring in nonfibrotic liver: epidemiologic and histopathologic analysis of 80 French cases. Hepatology 2000 32 (2) 200-204
    • (2000) Hepatology , vol.32 , Issue.2 , pp. 200-204
    • Bralet, M.P.1    Régimbeau, J.M.2    Pineau, P.3
  • 9
    • 4544273428 scopus 로고    scopus 로고
    • Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
    • Lee J S., Chu I S., Heo J et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 2004 40 (3) 667-676
    • (2004) Hepatology , vol.40 , Issue.3 , pp. 667-676
    • Lee, J.S.1    Chu, I.S.2    Heo, J.3
  • 10
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • Lee J S., Heo J, Libbrecht L et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 2006 12 (4) 410-416
    • (2006) Nat Med , vol.12 , Issue.4 , pp. 410-416
    • Lee, J.S.1    Heo, J.2    Libbrecht, L.3
  • 12
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S, Rickman D S., de Reynis A et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 2007 45 (1) 42-52
    • (2007) Hepatology , vol.45 , Issue.1 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    De Reynis, A.3
  • 13
    • 63349098247 scopus 로고    scopus 로고
    • Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene
    • Cieply B, Zeng G, Proverbs-Singh T, Geller D A., Monga S P. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology 2009 49 (3) 821-831
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 821-831
    • Cieply, B.1    Zeng, G.2    Proverbs-Singh, T.3    Geller, D.A.4    Monga, S.P.5
  • 14
    • 0345006147 scopus 로고    scopus 로고
    • Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
    • de La Coste A, Romagnolo B, Billuart P et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci U S A 1998 95 (15) 8847-8851
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.15 , pp. 8847-8851
    • De La Coste, A.1    Romagnolo, B.2    Billuart, P.3
  • 15
    • 0032761853 scopus 로고    scopus 로고
    • Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection
    • Huang H, Fujii H, Sankila A et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol 1999 155 (6) 1795-1801
    • (1999) Am J Pathol , vol.155 , Issue.6 , pp. 1795-1801
    • Huang, H.1    Fujii, H.2    Sankila, A.3
  • 16
    • 0033536185 scopus 로고    scopus 로고
    • Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity
    • Legoix P, Bluteau O, Bayer J et al. Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity. Oncogene 1999 18 (27) 4044-4046
    • (1999) Oncogene , vol.18 , Issue.27 , pp. 4044-4046
    • Legoix, P.1    Bluteau, O.2    Bayer, J.3
  • 17
    • 0032525836 scopus 로고    scopus 로고
    • Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3
    • Miyoshi Y, Iwao K, Nagasawa Y et al. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 1998 58 (12) 2524-2527
    • (1998) Cancer Res , vol.58 , Issue.12 , pp. 2524-2527
    • Miyoshi, Y.1    Iwao, K.2    Nagasawa, Y.3
  • 18
    • 0037130449 scopus 로고    scopus 로고
    • Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
    • Taniguchi K, Roberts L R., Aderca I N. et al. Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002 21 (31) 4863-4871
    • (2002) Oncogene , vol.21 , Issue.31 , pp. 4863-4871
    • Taniguchi, K.1    Roberts, L.R.2    Aderca, I.N.3
  • 19
    • 0033547371 scopus 로고    scopus 로고
    • Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas
    • Terris B, Pineau P, Bregeaud L et al. Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas. Oncogene 1999 18 (47) 6583-6588
    • (1999) Oncogene , vol.18 , Issue.47 , pp. 6583-6588
    • Terris, B.1    Pineau, P.2    Bregeaud, L.3
  • 20
    • 0035395236 scopus 로고    scopus 로고
    • Beta-catenin mutation and overexpression in hepatocellular carcinoma: Clinicopathologic and prognostic significance
    • Wong C M., Fan S T., Ng I O. Beta-catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer 2001 92 (1) 136-145
    • (2001) Cancer , vol.92 , Issue.1 , pp. 136-145
    • Wong, C.M.1    Fan, S.T.2    Ng, I.O.3
  • 21
    • 6944250147 scopus 로고    scopus 로고
    • Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas
    • Ishizaki Y, Ikeda S, Fujimori M et al. Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas. Int J Oncol 2004 24 (5) 1077-1083
    • (2004) Int J Oncol , vol.24 , Issue.5 , pp. 1077-1083
    • Ishizaki, Y.1    Ikeda, S.2    Fujimori, M.3
  • 22
    • 37249092516 scopus 로고    scopus 로고
    • Genetic alterations of Wnt signaling pathway-associated genes in hepatocellular carcinoma
    • Kim Y D., Park C H., Kim H S. et al. Genetic alterations of Wnt signaling pathway-associated genes in hepatocellular carcinoma. J Gastroenterol Hepatol 2008 23 (1) 110-118
    • (2008) J Gastroenterol Hepatol , vol.23 , Issue.1 , pp. 110-118
    • Kim, Y.D.1    Park, C.H.2    Kim, H.S.3
  • 23
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P, Legoix P, Bluteau O et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001 120 (7) 1763-1773
    • (2001) Gastroenterology , vol.120 , Issue.7 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3
  • 24
    • 14544270262 scopus 로고    scopus 로고
    • Mutations of beta-catenin and AXIN i genes are a late event in human hepatocellular carcinogenesis
    • Park J Y., Park W S., Nam S W. et al. Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis. Liver Int 2005 25 (1) 70-76
    • (2005) Liver Int , vol.25 , Issue.1 , pp. 70-76
    • Park, J.Y.1    Park, W.S.2    Nam, S.W.3
  • 25
    • 0034088858 scopus 로고    scopus 로고
    • AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
    • Satoh S, Daigo Y, Furukawa Y et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000 24 (3) 245-250
    • (2000) Nat Genet , vol.24 , Issue.3 , pp. 245-250
    • Satoh, S.1    Daigo, Y.2    Furukawa, Y.3
  • 26
    • 33846846541 scopus 로고    scopus 로고
    • Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas
    • Zucman-Rossi J, Benhamouche S, Godard C et al. Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas. Oncogene 2007 26 (5) 774-780
    • (2007) Oncogene , vol.26 , Issue.5 , pp. 774-780
    • Zucman-Rossi, J.1    Benhamouche, S.2    Godard, C.3
  • 27
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • [see comments]
    • Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. [see comments] Nature 1991 350 (6317) 429-431
    • (1991) Nature , vol.350 , Issue.6317 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3    Ozturk, M.4
  • 28
    • 0028867236 scopus 로고
    • The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan
    • Hayashi H, Sugio K, Matsumata T, Adachi E, Takenaka K, Sugimachi K. The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan. Hepatology 1995 22 (6) 1702-1707
    • (1995) Hepatology , vol.22 , Issue.6 , pp. 1702-1707
    • Hayashi, H.1    Sugio, K.2    Matsumata, T.3    Adachi, E.4    Takenaka, K.5    Sugimachi, K.6
  • 29
    • 15144343103 scopus 로고    scopus 로고
    • P53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation
    • Honda K, Sbis E, Tullo A et al. p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation. Br J Cancer 1998 77 (5) 776-782
    • (1998) Br J Cancer , vol.77 , Issue.5 , pp. 776-782
    • Honda, K.1    Sbis, E.2    Tullo, A.3
  • 30
    • 34047210411 scopus 로고    scopus 로고
    • TP53 mutations and hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer
    • Hussain S P., Schwank J, Staib F, Wang X W., Harris C C. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene 2007 26 (15) 2166-2176
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2166-2176
    • Hussain, S.P.1    Schwank, J.2    Staib, F.3    Wang, X.W.4    Harris, C.C.5
  • 31
    • 0026553679 scopus 로고
    • Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas
    • Challen C, Guo K, Collier J D., Cavanagh D, Bassendine M F. Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas. J Hepatol 1992 14 (2-3) 342-346
    • (1992) J Hepatol , vol.14 , Issue.23 , pp. 342-346
    • Challen, C.1    Guo, K.2    Collier, J.D.3    Cavanagh, D.4    Bassendine, M.F.5
  • 32
    • 0028983193 scopus 로고
    • Analysis of ras gene mutations in hepatocellular carcinoma in southern African blacks
    • Leon M, Kew M C. Analysis of ras gene mutations in hepatocellular carcinoma in southern African blacks. Anticancer Res 1995 15 (3) 859-861
    • (1995) Anticancer Res , vol.15 , Issue.3 , pp. 859-861
    • Leon, M.1    Kew, M.C.2
  • 33
    • 0024505982 scopus 로고
    • Activated N-ras gene was found in human hepatoma tissue but only in a small fraction of the tumor cells
    • Takada S, Koike K. Activated N-ras gene was found in human hepatoma tissue but only in a small fraction of the tumor cells. Oncogene 1989 4 (2) 189-193
    • (1989) Oncogene , vol.4 , Issue.2 , pp. 189-193
    • Takada, S.1    Koike, K.2
  • 34
    • 0024801490 scopus 로고
    • Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma
    • Tsuda H, Hirohashi S, Shimosato Y, Ino Y, Yoshida T, Terada M. Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma. Jpn J Cancer Res 1989 80 (3) 196-199
    • (1989) Jpn J Cancer Res , vol.80 , Issue.3 , pp. 196-199
    • Tsuda, H.1    Hirohashi, S.2    Shimosato, Y.3    Ino, Y.4    Yoshida, T.5    Terada, M.6
  • 35
    • 0035815230 scopus 로고    scopus 로고
    • INK4A methylation in hepatocellular carcinomas in workers exposed to vinyl chloride
    • DOI 10.1054/bjoc.2000.1675
    • Weihrauch M, Benicke M, Lehnert G, Wittekind C, Wrbitzky R, Tannapfel A. Frequent k- ras -2 mutations and p16(INK4A)methylation in hepatocellular carcinomas in workers exposed to vinyl chloride. Br J Cancer 2001 84 (7) 982-989 (Pubitemid 32385844)
    • (2001) British Journal of Cancer , vol.84 , Issue.7 , pp. 982-989
    • Weihrauch, M.1    Benicke, M.2    Lehnert, G.3    Wittekind, C.4    Wrbitzky, R.5    Tannapfel, A.6
  • 36
    • 18644363653 scopus 로고    scopus 로고
    • Bi-allelic inactivation of TCF1 in hepatic adenomas
    • Bluteau O, Jeannot E, Bioulac-Sage P et al. Bi-allelic inactivation of TCF1 in hepatic adenomas. Nat Genet 2002 32 (2) 312-315
    • (2002) Nat Genet , vol.32 , Issue.2 , pp. 312-315
    • Bluteau, O.1    Jeannot, E.2    Bioulac-Sage, P.3
  • 37
    • 58149326854 scopus 로고    scopus 로고
    • Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S, Amessou M, Couchy G et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 2009 457 (7226) 200-204
    • (2009) Nature , vol.457 , Issue.7226 , pp. 200-204
    • Rebouissou, S.1    Amessou, M.2    Couchy, G.3
  • 38
    • 0028023861 scopus 로고
    • Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma
    • Zhang X, Xu H J., Murakami Y et al. Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma. Cancer Res 1994 54 (15) 4177-4182
    • (1994) Cancer Res , vol.54 , Issue.15 , pp. 4177-4182
    • Zhang, X.1    Xu, H.J.2    Murakami, Y.3
  • 39
    • 0033624490 scopus 로고    scopus 로고
    • P16INK4 gene mutation and allelic loss of chromosome 9p21-22 in Taiwanese hepatocellular carcinoma
    • Chen T C., Hsieh L L., Kuo T T. et al. p16INK4 gene mutation and allelic loss of chromosome 9p21-22 in Taiwanese hepatocellular carcinoma. Anticancer Res 2000 20 (3A, 3A) 1621-1626
    • (2000) Anticancer Res , vol.20 , Issue.3 A , pp. 1621-1626
    • Chen, T.C.1    Hsieh, L.L.2    Kuo, T.T.3
  • 40
    • 0029665012 scopus 로고    scopus 로고
    • Infrequent alterations of the p16INK4A gene in liver cancer
    • Kita R, Nishida N, Fukuda Y et al. Infrequent alterations of the p16INK4A gene in liver cancer. Int J Cancer 1996 67 (2) 176-180
    • (1996) Int J Cancer , vol.67 , Issue.2 , pp. 176-180
    • Kita, R.1    Nishida, N.2    Fukuda, Y.3
  • 41
    • 0033590404 scopus 로고    scopus 로고
    • High frequency of p16INK4A gene alterations in hepatocellular carcinoma
    • Liew C T., Li H M., Lo K W. et al. High frequency of p16INK4A gene alterations in hepatocellular carcinoma. Oncogene 1999 18 (3) 789-795
    • (1999) Oncogene , vol.18 , Issue.3 , pp. 789-795
    • Liew, C.T.1    Li, H.M.2    Lo, K.W.3
  • 42
    • 20044388328 scopus 로고    scopus 로고
    • PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
    • Lee J W., Soung Y H., Kim S Y. et al. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 2005 24 (8) 1477-1480
    • (2005) Oncogene , vol.24 , Issue.8 , pp. 1477-1480
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 43
    • 33646672648 scopus 로고    scopus 로고
    • Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients
    • Tanaka Y, Kanai F, Tada M et al. Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients. Oncogene 2006 25 (20) 2950-2952
    • (2006) Oncogene , vol.25 , Issue.20 , pp. 2950-2952
    • Tanaka, Y.1    Kanai, F.2    Tada, M.3
  • 44
    • 0032622519 scopus 로고    scopus 로고
    • Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma
    • Kawate S, Takenoshita S, Ohwada S et al. Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma. Int J Oncol 1999 14 (1) 127-131
    • (1999) Int J Oncol , vol.14 , Issue.1 , pp. 127-131
    • Kawate, S.1    Takenoshita, S.2    Ohwada, S.3
  • 45
    • 0033606964 scopus 로고    scopus 로고
    • Smad2 and Smad4 gene mutations in hepatocellular carcinoma
    • Yakicier M C., Irmak M B., Romano A, Kew M, Ozturk M. Smad2 and Smad4 gene mutations in hepatocellular carcinoma. Oncogene 1999 18 (34) 4879-4883
    • (1999) Oncogene , vol.18 , Issue.34 , pp. 4879-4883
    • Yakicier, M.C.1    Irmak, M.B.2    Romano, A.3    Kew, M.4    Ozturk, M.5
  • 46
    • 38449101817 scopus 로고    scopus 로고
    • Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients
    • Bae J J., Rho J W., Lee T J. et al. Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. Oncol Rep 2007 18 (4) 1007-1013
    • (2007) Oncol Rep , vol.18 , Issue.4 , pp. 1007-1013
    • Bae, J.J.1    Rho, J.W.2    Lee, T.J.3
  • 47
    • 0034079163 scopus 로고    scopus 로고
    • PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas
    • Fujiwara Y, Hoon D S., Yamada T et al. PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas. Jpn J Cancer Res 2000 91 (3) 287-292
    • (2000) Jpn J Cancer Res , vol.91 , Issue.3 , pp. 287-292
    • Fujiwara, Y.1    Hoon, D.S.2    Yamada, T.3
  • 48
    • 0032938982 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations in hepatocellular carcinomas: Somatic inactivation of both alleles in tumors
    • Kawamura N, Nagai H, Bando K et al. PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors. Jpn J Cancer Res 1999 90 (4) 413-418
    • (1999) Jpn J Cancer Res , vol.90 , Issue.4 , pp. 413-418
    • Kawamura, N.1    Nagai, H.2    Bando, K.3
  • 49
    • 45149128115 scopus 로고    scopus 로고
    • Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target
    • Wang Y, Lee A T., Ma J Z. et al. Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. J Biol Chem 2008 283 (19) 13205-13215
    • (2008) J Biol Chem , vol.283 , Issue.19 , pp. 13205-13215
    • Wang, Y.1    Lee, A.T.2    Ma, J.Z.3
  • 50
    • 0033587014 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations in hepatocellular carcinomas
    • Yao Y J., Ping X L., Zhang H et al. PTEN/MMAC1 mutations in hepatocellular carcinomas. Oncogene 1999 18 (20) 3181-3185
    • (1999) Oncogene , vol.18 , Issue.20 , pp. 3181-3185
    • Yao, Y.J.1    Ping, X.L.2    Zhang, H.3
  • 51
    • 0028804071 scopus 로고
    • M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
    • De Souza A T., Hankins G R., Washington M K., Orton T C., Jirtle R L. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet 1995 11 (4) 447-449
    • (1995) Nat Genet , vol.11 , Issue.4 , pp. 447-449
    • De Souza, A.T.1    Hankins, G.R.2    Washington, M.K.3    Orton, T.C.4    Jirtle, R.L.5
  • 52
    • 18344372735 scopus 로고    scopus 로고
    • M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan
    • Oka Y, Waterland R A., Killian J K. et al. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan. Hepatology 2002 35 (5) 1153-1163
    • (2002) Hepatology , vol.35 , Issue.5 , pp. 1153-1163
    • Oka, Y.1    Waterland, R.A.2    Killian, J.K.3
  • 53
    • 0030928653 scopus 로고    scopus 로고
    • Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis
    • Yamada T, De Souza A T., Finkelstein S, Jirtle R L. Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis. Proc Natl Acad Sci U S A 1997 94 (19) 10351-10355
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.19 , pp. 10351-10355
    • Yamada, T.1    De Souza, A.T.2    Finkelstein, S.3    Jirtle, R.L.4
  • 54
    • 0345722740 scopus 로고    scopus 로고
    • Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas
    • Park W S., Dong S M., Kim S Y. et al. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res 1999 59 (2) 307-310
    • (1999) Cancer Res , vol.59 , Issue.2 , pp. 307-310
    • Park, W.S.1    Dong, S.M.2    Kim, S.Y.3
  • 55
    • 1342308489 scopus 로고    scopus 로고
    • The relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma
    • Yang D H., Huang W, Cui J et al. The relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2004 3 (1) 86-89
    • (2004) Hepatobiliary Pancreat Dis Int , vol.3 , Issue.1 , pp. 86-89
    • Yang, D.H.1    Huang, W.2    Cui, J.3
  • 56
    • 10744223577 scopus 로고    scopus 로고
    • Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas
    • Kim C J., Cho Y G., Park J Y. et al. Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas. Eur J Cancer 2004 40 (1) 136-141
    • (2004) Eur J Cancer , vol.40 , Issue.1 , pp. 136-141
    • Kim, C.J.1    Cho, Y.G.2    Park, J.Y.3
  • 57
    • 75449090631 scopus 로고    scopus 로고
    • Loss of HNF1a function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis
    • Pelletier L, Rebouissou S, Paris A et al. Loss of HNF1a function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis. Hepatology 2009 51 (2) 557-566
    • (2009) Hepatology , vol.51 , Issue.2 , pp. 557-566
    • Pelletier, L.1    Rebouissou, S.2    Paris, A.3
  • 58
    • 33645223878 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC
    • Zucman-Rossi J, Jeannot E, Nhieu J T. et al. Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 2006 43 (3) 515-524
    • (2006) Hepatology , vol.43 , Issue.3 , pp. 515-524
    • Zucman-Rossi, J.1    Jeannot, E.2    Nhieu, J.T.3
  • 59
    • 34250763945 scopus 로고    scopus 로고
    • Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
    • Bioulac-Sage P, Rebouissou S, Thomas C et al. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 2007 46 (3) 740-748
    • (2007) Hepatology , vol.46 , Issue.3 , pp. 740-748
    • Bioulac-Sage, P.1    Rebouissou, S.2    Thomas, C.3
  • 60
    • 84984537259 scopus 로고    scopus 로고
    • P53 gene and Wnt signaling in benign neoplasms: Beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia
    • Chen Y W., Jeng Y M., Yeh S H., Chen P J. P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. Hepatology 2002 36 (4 Pt 1) 927-935
    • (2002) Hepatology , vol.36 , Issue.4 PART 1 , pp. 927-935
    • Chen, Y.W.1    Jeng, Y.M.2    Yeh, S.H.3    Chen, P.J.4
  • 61
    • 36549031182 scopus 로고    scopus 로고
    • Nuclear beta-catenin staining and absence of steatosis are indicators of hepatocellular adenomas with an increased risk of malignancy
    • Van der Borght S, Libbrecht L, Katoonizadeh A et al. Nuclear beta-catenin staining and absence of steatosis are indicators of hepatocellular adenomas with an increased risk of malignancy. Histopathology 2007 51 (6) 855-856
    • (2007) Histopathology , vol.51 , Issue.6 , pp. 855-856
    • Van Der Borght, S.1    Libbrecht, L.2    Katoonizadeh, A.3
  • 62
    • 55249106920 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology
    • Cavard C, Colnot S, Audard V et al. Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology. Future Oncol 2008 4 (5) 647-660
    • (2008) Future Oncol , vol.4 , Issue.5 , pp. 647-660
    • Cavard, C.1    Colnot, S.2    Audard, V.3
  • 63
    • 0024755646 scopus 로고
    • Transmembrane control of cadherin-mediated cell adhesion: A 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin
    • Nagafuchi A, Takeichi M. Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin. Cell Regul 1989 1 (1) 37-44
    • (1989) Cell Regul , vol.1 , Issue.1 , pp. 37-44
    • Nagafuchi, A.1    Takeichi, M.2
  • 65
    • 0345830410 scopus 로고    scopus 로고
    • Morphogenesis of chicken liver: Identification of localized growth zones and the role of beta-catenin/Wnt in size regulation
    • Suksaweang S, Lin C M., Jiang T X., Hughes M W., Widelitz R B., Chuong C M. Morphogenesis of chicken liver: identification of localized growth zones and the role of beta-catenin/Wnt in size regulation. Dev Biol 2004 266 (1) 109-122
    • (2004) Dev Biol , vol.266 , Issue.1 , pp. 109-122
    • Suksaweang, S.1    Lin, C.M.2    Jiang, T.X.3    Hughes, M.W.4    Widelitz, R.B.5    Chuong, C.M.6
  • 66
    • 0037220834 scopus 로고    scopus 로고
    • Beta-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification
    • Monga S P., Monga H K., Tan X, Mulé K, Pediaditakis P, Michalopoulos G K. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology 2003 124 (1) 202-216
    • (2003) Gastroenterology , vol.124 , Issue.1 , pp. 202-216
    • Monga, S.P.1    Monga, H.K.2    Tan, X.3    Mulé, K.4    Pediaditakis, P.5    Michalopoulos, G.K.6
  • 67
    • 33744495398 scopus 로고    scopus 로고
    • Apc tumor suppressor gene is the zonation-keeper of mouse liver
    • Benhamouche S, Decaens T, Godard C et al. Apc tumor suppressor gene is the zonation-keeper of mouse liver. Dev Cell 2006 10 (6) 759-770
    • (2006) Dev Cell , vol.10 , Issue.6 , pp. 759-770
    • Benhamouche, S.1    Decaens, T.2    Godard, C.3
  • 68
    • 0037191930 scopus 로고    scopus 로고
    • New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism
    • Cadoret A, Ovejero C, Terris B et al. New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene 2002 21 (54) 8293-8301
    • (2002) Oncogene , vol.21 , Issue.54 , pp. 8293-8301
    • Cadoret, A.1    Ovejero, C.2    Terris, B.3
  • 69
    • 0035032989 scopus 로고    scopus 로고
    • Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration
    • Monga S P., Pediaditakis P, Mule K, Stolz D B., Michalopoulos G K. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology 2001 33 (5) 1098-1109
    • (2001) Hepatology , vol.33 , Issue.5 , pp. 1098-1109
    • Monga, S.P.1    Pediaditakis, P.2    Mule, K.3    Stolz, D.B.4    Michalopoulos, G.K.5
  • 70
    • 33750726092 scopus 로고    scopus 로고
    • Conditional deletion of beta-catenin reveals its role in liver growth and regeneration
    • Tan X, Behari J, Cieply B, Michalopoulos G K., Monga S P. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 2006 131 (5) 1561-1572
    • (2006) Gastroenterology , vol.131 , Issue.5 , pp. 1561-1572
    • Tan, X.1    Behari, J.2    Cieply, B.3    Michalopoulos, G.K.4    Monga, S.P.5
  • 71
    • 34347385893 scopus 로고    scopus 로고
    • Cholestasis is a marker for hepatocellular carcinomas displaying beta-catenin mutations
    • Audard V, Grimber G, Elie C et al. Cholestasis is a marker for hepatocellular carcinomas displaying beta-catenin mutations. J Pathol 2007 212 (3) 345-352
    • (2007) J Pathol , vol.212 , Issue.3 , pp. 345-352
    • Audard, V.1    Grimber, G.2    Elie, C.3
  • 72
    • 3042662347 scopus 로고    scopus 로고
    • Prognostic significance of beta-catenin nuclear expression in hepatocellular carcinoma
    • Fujito T, Sasaki Y, Iwao K et al. Prognostic significance of beta-catenin nuclear expression in hepatocellular carcinoma. Hepatogastroenterology 2004 51 (58) 921-924
    • (2004) Hepatogastroenterology , vol.51 , Issue.58 , pp. 921-924
    • Fujito, T.1    Sasaki, Y.2    Iwao, K.3
  • 73
    • 0034495080 scopus 로고    scopus 로고
    • Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis
    • Hsu H C., Jeng Y M., Mao T L., Chu J S., Lai P L., Peng S Y. Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000 157 (3) 763-770
    • (2000) Am J Pathol , vol.157 , Issue.3 , pp. 763-770
    • Hsu, H.C.1    Jeng, Y.M.2    Mao, T.L.3    Chu, J.S.4    Lai, P.L.5    Peng, S.Y.6
  • 74
    • 53049086329 scopus 로고    scopus 로고
    • Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
    • Chiang D Y., Villanueva A, Hoshida Y et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res 2008 68 (16) 6779-6788
    • (2008) Cancer Res , vol.68 , Issue.16 , pp. 6779-6788
    • Chiang, D.Y.1    Villanueva, A.2    Hoshida, Y.3
  • 75
    • 3042737316 scopus 로고    scopus 로고
    • Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver
    • Ovejero C, Cavard C, Périanin A et al. Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver. Hepatology 2004 40 (1) 167-176
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 167-176
    • Ovejero, C.1    Cavard, C.2    Périanin, A.3
  • 76
    • 24144434384 scopus 로고    scopus 로고
    • HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice
    • Lieu H T., Batteux F, Simon M T. et al. HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice. Hepatology 2005 42 (3) 618-626
    • (2005) Hepatology , vol.42 , Issue.3 , pp. 618-626
    • Lieu, H.T.1    Batteux, F.2    Simon, M.T.3
  • 77
    • 33847073865 scopus 로고    scopus 로고
    • Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer
    • Renard C A., Labalette C, Armengol C et al. Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer. Cancer Res 2007 67 (3) 901-910
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 901-910
    • Renard, C.A.1    Labalette, C.2    Armengol, C.3
  • 78
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 2009 136 (3) 1012-1024
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3
  • 79
    • 0015794601 scopus 로고
    • Possible association between benign hepatomas and oral contraceptives
    • Baum J K., Bookstein J J., Holtz F, Klein E W. Possible association between benign hepatomas and oral contraceptives. Lancet 1973 2 (7835) 926-929
    • (1973) Lancet , vol.2 , Issue.7835 , pp. 926-929
    • Baum, J.K.1    Bookstein, J.J.2    Holtz, F.3    Klein, E.W.4
  • 80
    • 0017463970 scopus 로고
    • A clinicopathologic study of steroid-related liver tumors
    • Christopherson W M., Mays E T., Barrows G. A clinicopathologic study of steroid-related liver tumors. Am J Surg Pathol 1977 1 (1) 31-41
    • (1977) Am J Surg Pathol , vol.1 , Issue.1 , pp. 31-41
    • Christopherson, W.M.1    Mays, E.T.2    Barrows, G.3
  • 81
    • 0017253557 scopus 로고
    • Liver-cell adenomas associated with use of oral contraceptives
    • Edmondson H A., Henderson B, Benton B. Liver-cell adenomas associated with use of oral contraceptives. N Engl J Med 1976 294 (9) 470-472
    • (1976) N Engl J Med , vol.294 , Issue.9 , pp. 470-472
    • Edmondson, H.A.1    Henderson, B.2    Benton, B.3
  • 82
    • 0017191654 scopus 로고
    • Benign liver tumors: What is their relationship to oral contraceptives?
    • Lansing P B., McQuitty J T., Bradburn D M. Benign liver tumors: what is their relationship to oral contraceptives? Am Surg 1976 42 (10) 744-760
    • (1976) Am Surg , vol.42 , Issue.10 , pp. 744-760
    • Lansing, P.B.1    McQuitty, J.T.2    Bradburn, D.M.3
  • 83
    • 84945702304 scopus 로고
    • Epidemiology of hepatocellular adenoma. the role of oral contraceptive use
    • Rooks J B., Ory H W., Ishak K G. et al. Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA 1979 242 (7) 644-648
    • (1979) JAMA , vol.242 , Issue.7 , pp. 644-648
    • Rooks, J.B.1    Ory, H.W.2    Ishak, K.G.3
  • 84
    • 0017567178 scopus 로고
    • Primary liver tumors and oral contraceptives. Results of a survey
    • Vana J, Murphy G P., Aronoff B L., Baker H W. Primary liver tumors and oral contraceptives. Results of a survey. JAMA 1977 238 (20) 2154-2158
    • (1977) JAMA , vol.238 , Issue.20 , pp. 2154-2158
    • Vana, J.1    Murphy, G.P.2    Aronoff, B.L.3    Baker, H.W.4
  • 85
    • 0017797440 scopus 로고
    • Effect of pregnancy on liver tumor associated with oral contraceptives
    • Kent D R., Nissen E D., Nissen S E., Ziehm D J. Effect of pregnancy on liver tumor associated with oral contraceptives. Obstet Gynecol 1978 51 (2) 148-151
    • (1978) Obstet Gynecol , vol.51 , Issue.2 , pp. 148-151
    • Kent, D.R.1    Nissen, E.D.2    Nissen, S.E.3    Ziehm, D.J.4
  • 86
    • 0020597557 scopus 로고
    • Hepatic adenoma and focal nodular hyperplasia: Clinical, pathologic, and radiologic features
    • Kerlin P, Davis G L., McGill D B., Weiland L H., Adson M A., Sheedy P F. II. Hepatic adenoma and focal nodular hyperplasia: clinical, pathologic, and radiologic features. Gastroenterology 1983 84 (5 Pt 1) 994-1002
    • (1983) Gastroenterology , vol.84 , Issue.5 PART 1 , pp. 994-1002
    • Kerlin, P.1    Davis, G.L.2    McGill, D.B.3    Weiland, L.H.4    Adson, M.A.5    Sheedy Ii, P.F.6
  • 87
    • 0028289597 scopus 로고
    • The malignant transformation of liver cell adenomas
    • Foster J H., Berman M M. The malignant transformation of liver cell adenomas. Arch Surg 1994 129 (7) 712-717
    • (1994) Arch Surg , vol.129 , Issue.7 , pp. 712-717
    • Foster, J.H.1    Berman, M.M.2
  • 88
    • 0023258127 scopus 로고
    • Hepatic adenoma within a spindle cell carcinoma in a woman with a long history of oral contraceptives
    • Grigsby P, Meyer J S., Sicard G A., Huggins M B., Lamar D J., DeSchryver-Kecskemeti K. Hepatic adenoma within a spindle cell carcinoma in a woman with a long history of oral contraceptives. J Surg Oncol 1987 35 (3) 173-179
    • (1987) J Surg Oncol , vol.35 , Issue.3 , pp. 173-179
    • Grigsby, P.1    Meyer, J.S.2    Sicard, G.A.3    Huggins, M.B.4    Lamar, D.J.5    Deschryver-Kecskemeti, K.6
  • 89
    • 0024584361 scopus 로고
    • Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use
    • Gyorffy E J., Bredfeldt J E., Black W C. Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use. Ann Intern Med 1989 110 (6) 489-490
    • (1989) Ann Intern Med , vol.110 , Issue.6 , pp. 489-490
    • Gyorffy, E.J.1    Bredfeldt, J.E.2    Black, W.C.3
  • 90
    • 0026038456 scopus 로고
    • Hepatocellular carcinoma coexisting with hepatic adenoma. Incidental discovery after long-term oral contraceptive use
    • Korula J, Yellin A, Kanel G, Campofiori G, Nichols P. Hepatocellular carcinoma coexisting with hepatic adenoma. Incidental discovery after long-term oral contraceptive use. West J Med 1991 155 (4) 416-418
    • (1991) West J Med , vol.155 , Issue.4 , pp. 416-418
    • Korula, J.1    Yellin, A.2    Kanel, G.3    Campofiori, G.4    Nichols, P.5
  • 91
    • 0025934127 scopus 로고
    • Oral contraceptive-associated liver cell adenoma and hepatocellular carcinoma. Cytomorphology and mechanism of malignant transformation
    • Tao L C. Oral contraceptive-associated liver cell adenoma and hepatocellular carcinoma. Cytomorphology and mechanism of malignant transformation. Cancer 1991 68 (2) 341-347
    • (1991) Cancer , vol.68 , Issue.2 , pp. 341-347
    • Tao, L.C.1
  • 92
    • 68949176929 scopus 로고    scopus 로고
    • Hepatocellular adenoma management and phenotypic classification: The Bordeaux experience
    • Bioulac-Sage P, Laumonier H, Couchy G et al. Hepatocellular adenoma management and phenotypic classification: The Bordeaux experience. Hepatology 2009 50 481-489
    • (2009) Hepatology , vol.50 , pp. 481-489
    • Bioulac-Sage, P.1    Laumonier, H.2    Couchy, G.3
  • 93
    • 0025732215 scopus 로고
    • Mutational hotspot in the p53 gene in human hepatocellular carcinomas
    • Hsu I C., Metcalf R A., Sun T, Welsh J A., Wang N J., Harris C C. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 1991 350 (6317) 427-428
    • (1991) Nature , vol.350 , Issue.6317 , pp. 427-428
    • Hsu, I.C.1    Metcalf, R.A.2    Sun, T.3    Welsh, J.A.4    Wang, N.J.5    Harris, C.C.6
  • 94
    • 0034897931 scopus 로고    scopus 로고
    • Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: A nested case-control study in Taiwan
    • Sun C A., Wang L Y., Chen C J. et al. Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan. Carcinogenesis 2001 22 (8) 1289-1294
    • (2001) Carcinogenesis , vol.22 , Issue.8 , pp. 1289-1294
    • Sun, C.A.1    Wang, L.Y.2    Chen, C.J.3
  • 95
    • 85047700502 scopus 로고    scopus 로고
    • Specific association between alcohol intake, high grade of differentiation and 4q34-q35 deletions in hepatocellular carcinomas identified by high resolution allelotyping
    • Bluteau O, Beaudoin J-C, Pasturaud P et al. Specific association between alcohol intake, high grade of differentiation and 4q34-q35 deletions in hepatocellular carcinomas identified by high resolution allelotyping. Oncogene 2002 21 (8) 1225-1232
    • (2002) Oncogene , vol.21 , Issue.8 , pp. 1225-1232
    • Bluteau, O.1    Beaudoin, J.-C.2    Pasturaud, P.3
  • 96
    • 70349739285 scopus 로고    scopus 로고
    • Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    • Hoshida Y, Nijman S M., Kobayashi M et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res 2009 69 (18) 7385-7392
    • (2009) Cancer Res , vol.69 , Issue.18 , pp. 7385-7392
    • Hoshida, Y.1    Nijman, S.M.2    Kobayashi, M.3
  • 97
    • 0035985214 scopus 로고    scopus 로고
    • Gene expression patterns in human liver cancers
    • Chen X, Cheung S T., So S et al. Gene expression patterns in human liver cancers. Mol Biol Cell 2002 13 (6) 1929-1939
    • (2002) Mol Biol Cell , vol.13 , Issue.6 , pp. 1929-1939
    • Chen, X.1    Cheung, S.T.2    So, S.3
  • 98
    • 4344652974 scopus 로고    scopus 로고
    • Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression
    • Breuhahn K, Vreden S, Haddad R et al. Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression. Cancer Res 2004 64 (17) 6058-6064
    • (2004) Cancer Res , vol.64 , Issue.17 , pp. 6058-6064
    • Breuhahn, K.1    Vreden, S.2    Haddad, R.3
  • 99
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • Kaposi-Novak P, Lee J S., Gmez-Quiroz L, Coulouarn C, Factor V M., Thorgeirsson S S. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 2006 116 (6) 1582-1595
    • (2006) J Clin Invest , vol.116 , Issue.6 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gmez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 100
    • 46249085489 scopus 로고    scopus 로고
    • Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
    • Coulouarn C, Factor V M., Thorgeirsson S S. Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology 2008 47 (6) 2059-2067
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 2059-2067
    • Coulouarn, C.1    Factor, V.M.2    Thorgeirsson, S.S.3
  • 101
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • Yamashita T, Forgues M, Wang W et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res 2008 68 (5) 1451-1461
    • (2008) Cancer Res , vol.68 , Issue.5 , pp. 1451-1461
    • Yamashita, T.1    Forgues, M.2    Wang, W.3
  • 102
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida Y, Villanueva A, Kobayashi M et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 2008 359 (19) 1995-2004
    • (2008) N Engl J Med , vol.359 , Issue.19 , pp. 1995-2004
    • Hoshida, Y.1    Villanueva, A.2    Kobayashi, M.3
  • 103
    • 10944254152 scopus 로고    scopus 로고
    • Transcription and processing of human microRNA precursors
    • Cullen B R. Transcription and processing of human microRNA precursors. Mol Cell 2004 16 (6) 861-865
    • (2004) Mol Cell , vol.16 , Issue.6 , pp. 861-865
    • Cullen, B.R.1
  • 104
    • 33646157967 scopus 로고    scopus 로고
    • Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
    • Murakami Y, Yasuda T, Saigo K et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2006 25 (17) 2537-2545
    • (2006) Oncogene , vol.25 , Issue.17 , pp. 2537-2545
    • Murakami, Y.1    Yasuda, T.2    Saigo, K.3
  • 105
    • 33749479908 scopus 로고    scopus 로고
    • Downregulation of miR-122 in the rodent and human hepatocellular carcinomas
    • Kutay H, Bai S, Datta J et al. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem 2006 99 (3) 671-678
    • (2006) J Cell Biochem , vol.99 , Issue.3 , pp. 671-678
    • Kutay, H.1    Bai, S.2    Datta, J.3
  • 106
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob S T., Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007 133 (2) 647-658
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 107
    • 34447117003 scopus 로고    scopus 로고
    • Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    • Gramantieri L, Ferracin M, Fornari F et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res 2007 67 (13) 6092-6099
    • (2007) Cancer Res , vol.67 , Issue.13 , pp. 6092-6099
    • Gramantieri, L.1    Ferracin, M.2    Fornari, F.3
  • 108
    • 37249006781 scopus 로고    scopus 로고
    • Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis
    • Huang Y S., Dai Y, Yu X F. et al. Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis. J Gastroenterol Hepatol 2008 23 (1) 87-94
    • (2008) J Gastroenterol Hepatol , vol.23 , Issue.1 , pp. 87-94
    • Huang, Y.S.1    Dai, Y.2    Yu, X.F.3
  • 109
    • 38949184246 scopus 로고    scopus 로고
    • Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival
    • Jiang J, Gusev Y, Aderca I et al. Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res 2008 14 (2) 419-427
    • (2008) Clin Cancer Res , vol.14 , Issue.2 , pp. 419-427
    • Jiang, J.1    Gusev, Y.2    Aderca, I.3
  • 110
    • 42249089850 scopus 로고    scopus 로고
    • MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma
    • Varnholt H, Drebber U, Schulze F et al. MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 2008 47 (4) 1223-1232
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1223-1232
    • Varnholt, H.1    Drebber, U.2    Schulze, F.3
  • 111
    • 46249083024 scopus 로고    scopus 로고
    • MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations
    • Ladeiro Y, Couchy G, Balabaud C et al. MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 2008 47 (6) 1955-1963
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 1955-1963
    • Ladeiro, Y.1    Couchy, G.2    Balabaud, C.3
  • 112
    • 51349165812 scopus 로고    scopus 로고
    • Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype
    • Connolly E, Melegari M, Landgraf P et al. Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol 2008 173 (3) 856-864
    • (2008) Am J Pathol , vol.173 , Issue.3 , pp. 856-864
    • Connolly, E.1    Melegari, M.2    Landgraf, P.3
  • 113
    • 40949087185 scopus 로고    scopus 로고
    • Identification of metastasis-related microRNAs in hepatocellular carcinoma
    • Budhu A, Jia H L., Forgues M et al. Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 2008 47 (3) 897-907
    • (2008) Hepatology , vol.47 , Issue.3 , pp. 897-907
    • Budhu, A.1    Jia, H.L.2    Forgues, M.3
  • 114
    • 70349871321 scopus 로고    scopus 로고
    • MicroRNA expression, survival, and response to interferon in liver cancer
    • Ji J, Shi J, Budhu A et al. MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med 2009 361 (15) 1437-1447
    • (2009) N Engl J Med , vol.361 , Issue.15 , pp. 1437-1447
    • Ji, J.1    Shi, J.2    Budhu, A.3
  • 115
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji J, Yamashita T, Budhu A et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009 50 (2) 472-480
    • (2009) Hepatology , vol.50 , Issue.2 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3
  • 116
    • 65449154685 scopus 로고    scopus 로고
    • Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
    • Ura S, Honda M, Yamashita T et al. Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology 2009 49 (4) 1098-1112
    • (2009) Hepatology , vol.49 , Issue.4 , pp. 1098-1112
    • Ura, S.1    Honda, M.2    Yamashita, T.3
  • 117
    • 68349160639 scopus 로고    scopus 로고
    • Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: Mir-338 is downregulated
    • Huang X H., Wang Q, Chen J S. et al. Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated. Hepatol Res 2009 39 (8) 786-794
    • (2009) Hepatol Res , vol.39 , Issue.8 , pp. 786-794
    • Huang, X.H.1    Wang, Q.2    Chen, J.S.3
  • 118
    • 59149098054 scopus 로고    scopus 로고
    • MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
    • Su H, Yang J R., Xu T et al. MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 2009 69 (3) 1135-1142
    • (2009) Cancer Res , vol.69 , Issue.3 , pp. 1135-1142
    • Su, H.1    Yang, J.R.2    Xu, T.3
  • 119
    • 65449170725 scopus 로고    scopus 로고
    • MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma
    • Li S, Fu H, Wang Y et al. MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma. Hepatology 2009 49 (4) 1194-1202
    • (2009) Hepatology , vol.49 , Issue.4 , pp. 1194-1202
    • Li, S.1    Fu, H.2    Wang, Y.3
  • 120
    • 70349976819 scopus 로고    scopus 로고
    • Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
    • Coulouarn C, Factor V M., Andersen J B., Durkin M E., Thorgeirsson S S. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene 2009 28 (40) 3526-3536
    • (2009) Oncogene , vol.28 , Issue.40 , pp. 3526-3536
    • Coulouarn, C.1    Factor, V.M.2    Andersen, J.B.3    Durkin, M.E.4    Thorgeirsson, S.S.5


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