2-(3-pyridyl)thiazolidine-4-carboxamide derivatives. II. Structure- activity relationships and active configuration of 2-(3- pyridyl)thiazolidine-4-carboxamides as platelet-activating factor receptor antagonists

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 9, 1998, Pages 1468-1473

  Suzuki, Takeshi ^a   Nagaoka, Hitoshi ^a   Kondo, Yutaka ^a   Takahashi, Takumi ^a   Takeuchi, Makoto ^a   Hara, Hiromu ^a   Saito, Munetoshi ^a   Yamada, Toshimitsu ^a   Tomioka, Kenichi ^a   Hamada, Mamoru ^a   Mase, Toshiyasu ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

2 (3 pyridyl)thiazolidine 4 carboxamide; Antagonist; Platelet activating factor; YM264; YM461

Indexed keywords

1 (3 METHYL 3 PHENYLBUTYL) 4 [2 (3 PYRIDYL) 4 THIAZOLIDINYLCARBONYL]PIPERAZINE; 1 (3 METHYL 3 PHENYLBUTYL) 4 [2 (3 PYRIDYL)THIAZOLIDINE 4 CARBONYL]PIPERAZINE; 1 (3 PHENYLPROPYL) 4 [2 (3 PYRIDYL) 4 THIAZOLIDINYLCARBONYL]PIPERAZINE FUMARATE; 2 (3 PYRIDYL)THIAZOLIDINE 4 CARBOXAMIDE DERIVATIVE; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG SYNTHESIS; ISOMERISM; NONHUMAN; RABBIT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA;

EID: 0031666229     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1468     Document Type: Article

References (24)

1. Nagaoka H., Hara H., Suzuki T., Takahashi T., Takauchi M., Matsuhisa A., Saito M., Yamada T., Tomioka K., Mase T., Chem. Pharm. Bull., 45, 1659-1664 (1997).
2. Deceased, July 22, 1996.
3. a) Page C. P., "Asthma: Basic Mechanisms and Clinical Management," ed. by Barns P. J., Rodger I. W., Thomson N. C., Academic Press. London, 1988, pp. 283-304
4. b) Pinckard R. N., Lundwig J. C., McManus L. M., "Inflammation: Basic Principles and Clinical Correlates," ed. by Gallin J. I., Goldstein I. M., Snyderman R., Raven Press, New York, 1988, pp. 139-167
5. c) Cooper K., Parry M., "Annual Reports in Medicinal Chemistry," Vol. 24, ed. by Allen R. C., Academic Press, New York, 1989, pp. 81-90, and references therein;
6. d) Hosford D., Braquet P., "Progress in Medicinal Chemistry," Vol. 27, ed. by Ellis G. P., West G. B., Elsevier Amsterdam, 1990, pp. 325-380.
7. Benveniste J., Le Couedic J. P., Kamoun P., Lancet, i, 344-345 (1975).
8. O'Flaherty J. T., Wykle R. L., Miller C. H., Lewis J. C., Waite M., Bass D. A., McCall C. E., DeChatelet L. O., Am. J. Pathol., 103, 70-79 (1981).
9. Vargaftig B. B., Lefort J., Chignard M., Benveniste J., Eur. J. Pharmacol., 65, 185-192 (1980).
10. Blank M. L., Snyder F., Beyers W., Brooks B., Muirhead D. E., Biochem. Biophys. Res. Commun., 90, 1194-1200 (1979).
11. Vemulapalli S., Chin P. J. S., Barnett A., Hypertension, 6, 489-493 (1984).
12. Vargaftig B. B., Benveniste J., Trends Pharmacol. Sci., 4, 341-343 (1983).
13. a) Tomioka K., Garrido R., Ahmed A., Stevenson S. S., Abraham W. M., Eur. J. Pharmacol., 170, 209-215 (1989)
14. b) Yamada T., Saito M., Mase T., Hara H., Nagaoka H., Murase K., Tomioka K., Lipids, 26, 1179-1183 (1991).
15. a) Yamada T., Tomioka K., Horie M., Mase T., Hara H., Nagaoka H., Arch. Int. Pharmacodyn. Therapie, 308, 123-136 (1990)
16. b) Yamada T., Tomioka K., Horie M., Sakurai Y., Nagaoka H., Mase T., Biochem. Biophys. Res. Commun., 176, 781-785 (1991).
17. a) Hellmann H., Dieterich D., Justus Liebigs Ann. Chem., 656, 53-63 (1962); idem, ibid., 672, 97-102 (1964)
18. a) Hellmann H., Dieterich D., Justus Liebigs Ann. Chem., 656, 53-63 (1962); idem, ibid., 672, 97-102 (1964)
19. b) Idem, Angew. Chem., 74, 78 (1962).
20. a) Fife T. H., Natarajan R., Shen C. C., Bembi R., J. Am. Chem. Soc., 113, 3071-3079 (1991)
21. b) Györgydeák Z., Kajtár-Peredy M., Kajtár J., Kajtár M., Justus Liebigs Ann. Chem., 1987, 927-934;
22. c) Sheppard G. S., Pireh D., Carrera G. M., Bures M. G., Heyman H. R., Steinman D. H., Davidsen S. K., Phillips J. G., Guinn D. E., May P. D., Conway R. G., Rhein D. A., Calhoun W. C., Albert D. H., Magoc T. J., Carter G. W., Summer J. B., J. Med. Chem., 37, 2011-2032 (1994)
23. d) Györgydeák Z., Szilágyi L., Kajtár J., Argay G., Kálmán A., Monatsch. Chem., 125, 189-208 (1994).
24. Born G. V. R., J. Physiol. (London), 162, 67-68 (1962).