Synthesis and antiplasmodial activity of new indolone N-Oxide derivatives

Journal of Medicinal Chemistry

Volumn 53, Issue 2, 2010, Pages 699-714

  Nepveu, Françoise ^a   Kim, Sothea ^a   Boyer, Jeremie ^a   Chatriant, Olivier ^b   Ibrahim, Hany ^a   Reybier, Karine ^a   Monje, Marie Carmen ^a   Chevalley, Severine ^a   Perio, Pierre ^a   Lajoie, Barbora H ^a   Bouajila, Jalloul ^a   Deharo, Eric ^a   Sauvain, Michel ^a   Tahar, Rachida ^c   Basco, Leonardo ^c   Pantaleo, Antonella ^d   Turini, Francesco ^d   Arese, Paolo ^d   Valentin, Alexis ^a   Thompson, Eloise ^e   Vivas, Livia ^e   Petit, Serge ^b   Nallet, Jean Pierre ^b   more..

^a UMR 152 IRD Universite Paul Sabatier   (France)

^b IDEALP PHARMA   (France)

^c Organisation de Coordination pour la Lutte contre les Endemies en Afrique Centrale Cameroon   (Cameroon)

^d UNIVERSITY OF TURIN   (Italy)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 DIMETHYLAMINOPHENYL) 5 METHOXY 1 OXYINDOL 3 ONE; 2 (4 ISOPROPOXYPHENYL) 5 METHOXY 1 OXYINDOL 3 ONE; 2 (4 METHOXYPHENYL) 3H INDOL 3 ONE N OXIDE; 6 (4 CHLOROPHENYL) 7H [1,3]DIOXOLO[4,5 F]INDOL 7 ONE 5 OXIDE; ANTIMALARIAL AGENT; ARTEMETHER; ARTESUNATE; CHLOROQUINE; CYCLOGUANIL; PODOPHYLLOTOXIN; PYRIMETHAMINE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALARIA; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANIMALS; ANTIMALARIALS; CELL LINE, TUMOR; DRUG RESISTANCE; HUMANS; INDOLES; OXIDES; PARASITEMIA; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77249160242     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901300d     Document Type: Article

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