Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives

Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

Volumn 42, Issue 3, 2006, Pages 357-361

  Zarranz, Belén ^a   Jaso, Andrés ^a   Lima, Lidia Moreira ^a,c   Aldana, Ignacio ^a   Monge, Antonio ^a   Maurel, Séverine ^b   Sauvain, Michel ^b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UMR 152 IRD Universite Paul Sabatier   (France)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Antimalarial; Chloroquine; MCF7; Quinoxaline

Indexed keywords

3 TRIFLUOROMETHYL 2 CARBONYLQUINOXALINE DI N OXIDE DERIVATIVE; ANTIMALARIAL AGENT; QUINOXALINE DI N OXIDE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM;

EID: 33845483659     PISSN: 15169332     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1516-93322006000300005     Document Type: Article

References (8)

1. DELHAES, B.J.; DANIS, M.; GAY, F.; LAZARO, J.E.; THELLIER, M. The microculture tetrazolium assay (MTA): another colorimetric method of testing Plasmodium falciparum chemosensitivity. Ann. Trop. Med. Parasitol., v.93, p.31-40, 1999.
2. GREENWOOD, B.M.; BOJANG, K.; WHITTY, C.J.M.; TARGETT, G.A.T. Malaria. Lancer, v.365, p.1487-1498, 2005.
3. GUILLON, J.; GRELLIER, P.; LABAIED, M.; SONNET, P.; LÉGER, J.M.; DEPREZ-POULAIN, R.; FORFAR-BARES, I.; DALLEMAGNE, P.; LEMAÎTRE, N.; PÉHOURCQ, F.; ROCHETTE, J.; SERGHERAERT, C.; JARRY, C. Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines. J. Med. Chem., v.47, p.1997-2009, 2004.
4. JASO, A.; ALDANA, I.; MONGE, A.; ZARRANZ, B. Synthesis of New 2-acetyl and 2-benzoyl Quinoxaline 1,4-di-N-oxide Derivatives as Anti-Mycobacterium tuberculosis Agents. Eur. J. Med. Chem., v.38, p.791-800, 2003.
5. ORTEGA, M.A.; ALDANA, I.; JASO, A.; MONGE, A.; MONTOYA, M.E.; SAINZ, Y.; ZARRANZ, B. Anti-Mycobacterium tuberculosis agents derived from quinoxaline-2-carbonitrile and quinoxaline-2-carbonitrile 1,4-di-N-oxide. Arzneim. Forsch. Drug Research, v.52, p.113-119, 2002.
6. TABBI, G.; CASSINO, C.; CAVIGIOLIO, G.; COLANGELO, D.; GHIGLIA, A.; OSELLA, D.; VIANO, I. Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process. J. Med. Chem., v.45, p.5786-5796, 2002.
7. ZARRANZ, B.; ALDANA, I.; JASO, A.; MONGE, A. Synthesis and Antimycobacterial Activity of New Quinoxaline-2-carboxamide 1,4-di-N-oxide Derivatives. Bioorg. Mad. Chem., v.11, p.2149-2156, 2003.
8. ZARRANZ, B.; ALDANA, I.; JASO, A.; MONGE, A. Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3- trifluoromethylquinoxaline 1,4-di-N-oxide derivatives. Bioorg. Med. Chem., v.12, p.3711-3721, 2004.