Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives

Journal of Medicinal Chemistry

Volumn 53, Issue 3, 2010, Pages 966-982

  Fotie, Jean ^a,e   Kaiser, Marcel ^b   Delfín, Dawn A ^a   Manley, Joshua ^a   Reid, Carolyn S ^a   Paris, Jean Marc ^c   Wenzler, Tanja ^b   Maes, Louis ^d   Mahasenan, Kiran V ^a   Li, Chenglong ^a   Werbovetz, Karl A ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c PSL RESEARCH UNIVERSITY   (France)

^d UNIVERSITY OF ANTWERP   (Belgium)

^e SOUTHEASTERN LOUISIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 (TRIFLUOROMETHYL)BENZYL) 6 (3 (TRIFLUOROMETHYL)BENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 1 (3 CYANOBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 (3 METHOXYBENZYL) 6 (3 METHOXYBENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 1 (3,5 DIMETHOXYBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 (4 (TRIFLUOROMETHYL)BENZYL) 6 (4 (TRIFLUOROMETHYL)BENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 1 (4 CHLOROBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 (4 CYANOBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 (4 FLUOROBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 (4 METHYLBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 BENZYL 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1,2 DIHYDRO 2,2,4 TRIMETHYL 1 ((PYRIDIN 2 YL)METHYL)QUINOLIN 6 OL; 1,2 DIHYDRO 2,2,4 TRIMETHYL 1 ((PYRIDIN 4 YL)METHYL)QUINOLIN 6 OL; 1,2 DIHYDRO 2,2,4 TRIMETHYL 6 (PHENETHYLOXY)QUINOLINE; 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 OL; 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL 3,5 DIMETHOXYBENZOATE; 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL BENZO[D][1,3]DIOXOLE 5 CARBOXYLATE; 6 (2 METHOXYBENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 6 (3 (TRIFLUOROMETHYL)BENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 6 (3 METHOXYBENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 6 (3,5 DIMETHOXYBENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 6 (4 (TRIFLUOROMETHYL)BENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 6 (4 METHOXYBENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 6 (BENZYLOXY) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; ANTITRYPANOSOMAL AGENT; BIS(1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL) ISOPHTHALATE; MELARSOPROL; PODOPHYLLOTOXIN; QUINOLIN 6 YL 3,5 DIMETHOXYBENZOATE; QUINOLIN 6 YL BENZO[D][1,3]DIOXOLE 5 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIFESPAN; MOUSE; NONHUMAN; OXIDATIVE STRESS; RAT; TRYPANOSOMA RHODESIENSE;

ACETATES; ANIMALS; CELLS, CULTURED; ESTERS; HUMANS; MICE; MOLECULAR STRUCTURE; MYOBLASTS; QUINOLINES; RATS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; SURVIVAL RATE; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 77249149395     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm900723w     Document Type: Article

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