Discovery and SAR study of novel dihydroquinoline containing glucocorticoid receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 6, 2006, Pages 1549-1552

  Takahashi, Hidenori ^a   Bekkali, Younes ^a   Capolino, Alison J ^a   Gilmore, Thomas ^a   Goldrick, Susan E ^a   Nelson, Richard M ^a   Terenzio, Donna ^a   Wang, Ji ^a   Zuvela Jelaska, Ljiljana ^a   Proudfoot, John ^a   Nabozny, Gerald ^a   Thomson, David ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Glucocorticoid receptor; Ligand; SAR

Indexed keywords

1,2 DIHYDROQUINOLINE; AL 438; DIHYDROQUINOLINE DERIVATIVE; GLUCOCORTICOID RECEPTOR; HORMONE RECEPTOR; LG 001447; MIFEPRISTONE; NITROGEN; OXYGEN; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CROSS COUPLING REACTION; DRUG SELECTIVITY; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; HELA CELLS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LIGANDS; MAMMARY TUMOR VIRUS, MOUSE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROMOTER REGIONS (GENETICS); QUINOLINES; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 32044456664     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.043     Document Type: Article

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