Lewis-acid catalyzed reaction of 2-isopropenylaniline with ketones: Improved synthesis of 2,2,4-trisubstituted 1,2-dihydroquinolines

Tetrahedron Letters

Volumn 39, Issue 29, 1998, Pages 5139-5142

  Edwards, James P ^a   Ringgenberg, Josef D ^a   Jones, Todd K ^a  

^a LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ISOPROPENYLANILINE; DIHYDROQUINOLINE DERIVATIVE; DRUG VEHICLE; KETONE; STYRENE; TOLUENE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CATALYST; CYCLIZATION; DRUG SYNTHESIS; STEREOCHEMISTRY;

EID: 0032537667     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01010-7     Document Type: Article

References (21)

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19. 9. The yield of dihydroquinoline from isopropenyl aniline and 3-niethylcyclohexanone under these conditions is reported to be 38%; see Ref. 7a.
20. 1H decoupling and n.O.e. experiments. (Equation Presented)
21. 1H NMR data: (Equation Presented)