Nifurtimox plus eflornithine for late-stage sleeping sickness in Uganda: A case series

PLoS Neglected Tropical Diseases

Volumn 1, Issue 2, 2007, Pages

  Checchi, Francesco ^a,b   Piola, Patrice ^a   Ayikoru, Harriet ^c   Thomas, Florence ^a   Legros, Dominique ^a,d   Priotto, Gerardo ^a  

^a EPICENTRE   (France)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c MÉDECINS SANS FRONTIÈRES   (Switzerland)

^d WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EFLORNITHINE; NIFURTIMOX; ANTITRYPANOSOMAL AGENT;

ABDOMINAL PAIN; ADOLESCENT; ADULT; AFRICAN TRYPANOSOMIASIS; AGITATION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMNESIA; ANEMIA; ANOREXIA; ARTHRALGIA; ARTICLE; ATAXIA; BILIRUBIN BLOOD LEVEL; CASE STUDY; CLINICAL ARTICLE; CLINICAL TRIAL; COMA; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DEATH; DIARRHEA; DIZZINESS; DROWSINESS; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG WITHDRAWAL; EPISTAXIS; FEMALE; FEVER; FOLLOW UP; HALLUCINATION; HEADACHE; HEART ARRHYTHMIA; HOSPITAL DISCHARGE; HUMAN; HYPERTENSION; INFECTION; JAUNDICE; LEUKOPENIA; MALE; MYALGIA; NAUSEA AND VOMITING; NEUTROPENIA; OUTCOME ASSESSMENT; PATIENT MONITORING; PRURITUS; RASH; RELAPSE; SEIZURE; SHIVERING; SIDE EFFECT; SPLENOMEGALY; SURVIVAL RATE; THORAX PAIN; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT OUTCOME; TREMOR; TRYPANOSOMA GAMBIENSE; UGANDA; VISUAL IMPAIRMENT; WEIGHT REDUCTION; CHILD; MIDDLE AGED; PRESCHOOL CHILD; PROSPECTIVE STUDY;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; EFLORNITHINE; FEMALE; HUMANS; MALE; MIDDLE AGED; NIFURTIMOX; PROSPECTIVE STUDIES; TREATMENT OUTCOME; TRYPANOCIDAL AGENTS; TRYPANOSOMIASIS, AFRICAN; UGANDA; YOUNG ADULT;

EID: 39849106323     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000064     Document Type: Article

References (16)

1. Stich A, Barrett MP, Krishna S (2003) Waking up to sleeping sickness. Trends Parasitol 19: 195-197.
2. Barrett MP, Burchmore RJ, Stich A, Lazzari JO, Frasch AC, et al. (2003) The trypanosomiases. Lancet 362: 1469-1480.
3. Stewart ML, Krishna S, Burchmore RJ, Brun R, de Koning HP, et al. (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet 366: 486-487.
4. Balasegaram M, Harris S, Checchi F, Ghorashian S, Hamel C, et al. (2006) Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo. Bull World Health Organ 84: 783-791.
5. Chappuis F, Udayraj N, Stietenroth K, Meussen A, Bovier PA (2005) Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis. Clin Infcct Dis 41: 748-751.
6. Burri C, Brun R (2003) Eflomithine for the treatment of human African trypanosomiasis. Parasitol Res 90 Supp 1: S49-52.
7. Pepin J, Khonde N, Maiso F, Doua F, Jaffar S, et al. (2000) Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial. Bull World Health Organ 78: 1284-1295.
8. Bisser S, N'Siesi FX, Lejon V, Preux PM, Van Nicuwenhove S, et al. (2007) Equivalence Trial of Melarsoprol and Nifurtimox Monotherapy and Combination Therapy for the Treatment of Second-Stage Trypanosoma brucei gambiense Sleeping Sickness. J Infect Dis 195: 322-329.
9. Medecins Sans Frontieres Campaign for Access to Essential Medicines (2006) Human African trypanosomiasis: facing the challenges causes by neglect: The need for new treatment and diagnostics. Geneva: Medecins Sans Frontieres.
10. Priotto G, Fogg C, Balasegaram M, Erphas O, Louga A, et al. (2006) Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda. PLoS Clin Trials 1: e39.
11. Legros D, Fournier C, Gastellu Etchegorry M, Maiso F, Szumilin E (1999) [Therapeutic failure of melarsoprol among patients treated for late stage T.b. gambiense human African trypanosomiasis in Uganda). Bull Soc Pathol Exot 92: 171-172.
12. National Cancer Institute CTEP, National Institutes of Health (1999) Common Toxicity Criteria, version 2.0.
13. Schmid C, Nkunku S, Merolle A, Vounatsou P, Burri C (2004) Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness. Lancet 364: 789-790.
14. Schmid C, Richer M, Bilenge CM, Josenando T, Chappuis F, et al. (2005) Effectiveness of a 10-Day Melarsoprol Schedule for the Treatment of Late-Stage Human African Trypanosomiasis: Confirmation from a Multinational Study (Impamel II). J Infect Dis 191: 1922-1931.
15. Mpia B, Pepin J (2002) Combination of eflornithine and melarsoprol for melarsoprol-resistant Gambian trypanosomiasis. Trop Med Int Health 7: 775-779.
16. Croft SL, Barrett MP, Urbina JA (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends Parasitol 21: 508-512.