Dopaminergic profile of new heterocyclic N-phenylpiperazine derivatives

Brazilian Journal of Medical and Biological Research

Volumn 36, Issue 5, 2003, Pages 625-629

  Neves, G ^a   Fenner, R ^a   Heckler, A P ^a   Viana, A F ^a   Tasso, L ^a   Menegatti, R ^b   Fraga, C A M ^b   Barreiro, E J ^b   Dalla Costa, T ^a   Rates, S M K ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Amphetamine stereotypy; Apomorphine hypothermia; Catalepsy; Dopamine; N phenylpiperazine derivatives

Indexed keywords

1 AMINOMETHYL 5,6 DIHYDROXY 3 PHENYLISOCHROMAN; 1 [1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YLMETHYL] 4 PHENYLHEXAHYDROPYRAZINE; 1 [1 (4 CHLOROPHENYL) 1H 4 PYRAZOLYLMETHYL] 4 PHENYLHEXAHYDROPYRAZINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; AMPHETAMINE; APOMORPHINE; CATECHOLAMINE DERIVATIVE; CLOZAPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; HALOPERIDOL; PIPERAZINE DERIVATIVE; QUINPIROLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; HYPOTHERMIA; MALE; MOUSE; NONHUMAN; RAT; RECTUM TEMPERATURE; SEROTONINERGIC SYSTEM; STEREOTYPY; STRUCTURE ANALYSIS; THERMOREGULATION;

ANIMALIA;

EID: 0037603647     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2003000500010     Document Type: Article

References (20)

1. Vallone D, Picetti R & Borrelli E (2000). Structure and function of dopamine receptors. Neuroscience and Biobehavioral Reviews, 24: 125-132.
2. Baldessarini RJ (1996). Drugs and the treatment of psychiatric disorders: Psychosis and anxiety. In: Hardman JG & Limbird LE (Editors), Goodman & Gilman's - The Pharmacological Basis of Therapeutics. 9th edn. McGraw-Hill, New York, NY, USA.
3. Stahl P (2000). Essential Psychopharmacology - Neuroscientific Basis and Practical Applications. 2nd edn. Cambridge University Press, New York, NY, USA.
4. Crismon ML & Dorson PG (1997). Schizophrenia. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG & Posey LM (Editors), Pharmacotherapy - A Pathophysiological Approach. 3rd edn. Appleton & Lange, Stamford, UK.
5. Thurkauf A, Yuan J, Chen X et al. (1997). 2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D-4 receptors. Journal of Medicinal Chemistry, 40: 1-3.
6. 4 receptor. Journal of Medicinal Chemistry, 39: 1941-1942.
7. Carlini EA (1973). Farmacologia Prática sem Aparelhagens. Sarvier, São Paulo, SP, Brazil.
8. Verma A & Kulkarni SK (1993). Differential role of dopamine receptor subtypes in thermoregulation and stereotypic behavior in naive and reserpinized rats. Archives Internationales de Pharmacodynamie et de Therapie, 324: 17-32.
9. Moore NC & Gershon S (1989). Which atypical antipsychotics are identified by screening tests? Clinical Neuropharmacology, 12: 167-184.
10. Sanberg PR, Bunsey MD, Giordano M & Norman A (1988). The catalepsy test: its ups and downs. Behavioral Neuroscience, 102: 748-759.
11. Weiss JM & Kilts CD (1998). Animal models of depression and schizophrenia. In: Schatzberg AF & Nemeroff CB (Editors). Textbook of Psychopharmacology. American Psychiatric Press, Washington, DC, USA.
12. 2 receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects. Neuropsycopharmacology, 25: 633-641.
13. 2 receptors in the regulation of body temperature in the rat. European Journal of Pharmacology, 236: 395-400.
14. Puech AJ, Frances H & Simon P (1978). Imipramine antagonism of apomorphine-induced hypothermia: A non-dopaminergic interaction. European Journal of Pharmacology, 47: 125-127.
15. 2-mediated hypothermic response in mice. Life Sciences, 43: 871-881.
16. 2/3 receptors in rat thermoregulation. Brain Research, 781: 188-193.
17. 2A receptors in rat thermoregulatory mechanisms. Pharmacology and Toxicology, 82: 122-127.
18. 2) receptor agonist 1(2,5-dimethoxy-4-iodophenyl -2-aminopropane (DOI) inhibits chlopromazine-induced and haloperidol-induced hypothermia in mice. Biological and Pharmaceutical Bulletin, 18: 1580-1683.
19. Salmi P, Karlsson T & Ahlenius S (1994). Antagonism by SCH23390 of clozapine-induced hypothermia in the rat. European Journal of Pharmacology, 253: 67-73.
20. 1 receptor agonist. European Journal of Pharmacology, 307: 27-31.