Structural discovery of small molecule binding sites in Cu-Zn human superoxide dismutase familial amyotrophic lateral sclerosis mutants provides insights for lead optimization

Journal of Medicinal Chemistry

Volumn 53, Issue 3, 2010, Pages 1402-1406

  Antonyuk, Svetlana ^a   Strange, Richard W ^a   Hasnain, S Samar ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 TRIFLUOROMETHYL 4 AMINOQUINAZOLINE; ANILINE; COPPER ZINC SUPEROXIDE DISMUTASE; LEAD; METHIONINE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; ENZYME ACTIVITY; FAMILIAL DISEASE; FRAGMENTATION REACTION; LIGAND BINDING; MOLECULE; MUTANT; OXIDATIVE STRESS; PATHOGENESIS; X RAY CRYSTALLOGRAPHY;

AMYOTROPHIC LATERAL SCLEROSIS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MODELS, CHEMICAL; MUTATION; SMALL MOLECULE LIBRARIES; SUPEROXIDE DISMUTASE;

EID: 77249111207     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9017948     Document Type: Article

References (24)

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