Regulation of gene expression in mouse macrophages stimulated with bacterial CpG-DNA and lipopolysaccharide

Journal of Leukocyte Biology

Volumn 72, Issue 6, 2002, Pages 1234-1245

  Gao, Jian Jun ^a,d   Diesl, Veronica ^b   Wittmann, Tatiana ^a   Morrison, David C ^a   Ryan, John L ^b   Vogel, Stefanie N ^c   Follettie, Maximillian T ^b  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b PFIZER INC   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular activation; Gene regulation; Inflammation; Microarray

Indexed keywords

BACTERIAL DNA; BACTERIUM LIPOPOLYSACCHARIDE; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOMODULATING AGENT; OLIGODEOXYNUCLEOTIDE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; IMMUNE RESPONSE; IMMUNOMODULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; UNINDEXED SEQUENCE;

ANIMALS; CELL LINE; DNA, BACTERIAL; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MACROPHAGES; MICE; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0036908870     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Pisetsky, D. S. (1997) DNA and the immune system. Ann. Intern. Med. 126, 169-171.
2. Weiner, G. J. (2000) The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. J. Leukoc. Biol. 68, 455-463.
3. Shimada, S., Yano, O., Tokunaga, T. (1986) In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG. Jpn. J. Cancer Res. 77, 808-816.
4. Messina, J. P., Gilkeson, G. S., Pisetsky, D. S. (1991) Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147, 1759-1764.
5. Krieg, A. M., Yi, A. K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., Klinman, D. M. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546-549.
6. Bird, A. P. (1993) Functions for DNA methylation in vertebrates. Cold Spring Harb. Symp. Quant. Biol. 58, 281-285.
7. Hergersberg, M. (1991) Biological aspects of cytosine methylation in eukaryotic cells. Experientia 47, 1171-1185.
8. Lipford, G. B., Heeg, K., Wagner, H. (1998) Bacterial DNA as immune cell activator. Trends Microbiol. 6, 496-500.
9. Heeg, K., Zimmermann, S. (2000) CpG DNA as a Th1 trigger. Int. Arch. Allergy Immunol. 121, 87-97.
10. Kline, J. N. (2000) Effects of CpG DNA on Th1/Th2 balance in asthma. Curr. Top. Microbiol. Immunol. 247, 211-225.
11. Heeg, K., Sparwasser, T., Lipford, G. B., Hacker, H., Zimmermann, S., Wagner, H. (1998) Bacterial DNA as an evolutionary conserved ligand signaling danger of infection to immune cells. Eur. J. Clin. Microbiol. Infect. Dis. 17, 464-469.
12. Pisetsky, D. S. (1996) Immune activation by bacterial DNA: A new genetic code. Immunity 5, 303-310.
13. Roman, M., Martin-Orozco, E., Goodman, J. S., Nguyen, M. D., Sato, Y., Ronaghy, A., Kornbluth, R. S., Richman, D. D., Carson, D. A., Raz, E. (1997) Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3, 849-854.
14. Sparwasser, T., Miethke, T., Lipford, G., Borschert, K., Hacker, H., Heeg, K., Wagner, H. (1997) Bacterial DNA causes septic shock. Nature 386, 336-337.
15. Cowdery, J. S., Chace, J. H., Yi, A. K., Krieg, A. M. (1996) Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156, 4570-4575.
16. Gao, J. J., Zuvanich, E. G., Xue, Q., Horn, D. L., Silverstein, R., Morrison, D. C. (1999) Cutting edge: Bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages. J. Immunol. 163, 4095-4099.
17. Gao, J. J., Xue, Q., Papasian, C. J., Morrison, D. C. (2001) Bacterial DNA and lipopolysaccharide induce synergistic production of TNF-alpha through a post-transcriptional mechanism. J. Immunol. 166, 6855-6860.
18. Sparwasser, T., Miethke, T., Lipford, G., Erdmann, A., Hacker, H., Heeg, K., Wagner, H. (1997) Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock. Eur. J. Immunol. 27, 1671-1679.
19. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., Akira, S. (2000) Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745.
20. Hacker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R., Sparwasser, T., Heeg, K., Lipford, G. B., Wagner, H. (1998) CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17, 6230-6240.
21. Yi, A. K., Krieg, A. M. (1998) Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA. J. Immunol. 161, 4493-4497.
22. Stacey, K. J., Sweet, M. J., Hume, D. A. (1996) Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157, 2116-2122.
23. Krieg, A. M. (2000) Signal transduction induced by immunostimulatory CpG DNA. Springer Semin. Immunopathol. 22, 97-105.
24. Du, X., Poltorak, A., Wei, Y., Beutler, B. (2000) Three novel mammalian toll-like receptors: Gene structure, expression, and evolution. Eur. Cytokine Netw. 11, 362-371.
25. Hacker, H., Vabulas, R. M., Takeuchi, O., Hoshino, K., Akira, S., Wagner, H. (2000) Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192, 595-600.
26. Schnare, M., Holtdagger, A. C., Takeda, K., Akira, S., Medzhitov, R. (2000) Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr. Biol. 10, 1139-1142.
27. Kawai, T., Adachi, O., Ogawa, T., Takeda, K., Akira, S. (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 10, 115-122.
28. Stacey, K. J., Sester, D. P., Sweet, M. J., Hume, D. A. (2000) Macrophage activation by immunostimulatory DNA. Curr. Top. Microbiol. Immunol. 247, 41-58.
29. Byrne, M. C., Whitley, M. Z., Follettie, M. T. (2000) Preparation of mRNA for expression monitoring. In Current Protocols in Molecular Biology. New York, NY, John Wiley and Sons, 22.2.1.
30. Cho, N. H., Seong, S. Y., Huh, M. S., Han, T. H., Koh, Y. S., Choi, M. S., Kim, I. S. (2000) Expression of chemokine genes in murine macrophages infected with Orientia tsutsugamushi. Infect. Immun. 68, 594-602.
31. Scherr, M., Rossi, J. J. (1998) Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts. Nucleic Acids Res. 26, 5079-5085.
32. Hill, A. A., Brown, E. L., Whitley, M. Z., Tucker-Kellogg, G., Hunter, C. P., Slonim, D. K. (2001) Evaluation of normalization procedures for oligonucleotide array data base on spiked cRNA controls. Genome Biol. 2: Research 0055.1.
33. Lockhart, D. J., Dong, H., Byrne, M. C., Follettie, M. T., Gallo, M. V., Chee, M. S., Mittmann, M., Wang, C., Kobayashi, M., Horton, H., Brown, E. L. (1996) Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat. Biotechnol. 14, 1675-1680.
34. Chu, W., Gong, X., Li, Z., Takabayashi, K., Ouyang, H., Chen, Y., Lois, A., Chen, D. J., Li, G. C., Karin, M., Raz, E. (2000) DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell 103, 909-918.
35. Rosenberger, C. M., Scott, M. G., Gold, M. R., Hancock, R. E., Finlay, B. B. (2000) Salmonella typhimurium infection and lipopolysaccharide stimulation induce similar changes in macrophage gene expression. J. Immunol. 164, 5894-5904.
36. Ravasi, T., Wells, C., Forest, A., Underhill, D. M., Wainwright, B. J., Aderem, A., Grimmond, S., Hume, D. A. (2002) Generation of diversity in the innate immune system: Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. J. Immunol. 168, 44-50.
37. Vairo, G., Royston, A. K., Hamilton, J. A. (1992) Biochemical events accompanying macrophage activation and the inhibition of colony-stimulating factor-1-induced macrophage proliferation by tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide. J. Cell. Physiol. 151, 630-641.
38. Vadiveloo, P. K., Vairo, G., Novak, U., Royston, A. K., Whitty, G., Filonzi, E. L., Cragoe Jr., E. J., Hamilton, J. A. (1996) Differential regulation of cell cycle machinery by various antiproliferative agents is linked to macrophage arrest at distinct G1 checkpoints. Oncogene 13, 599-608.
39. Horng, T., Barton, G. M., Medzhitov, R. (2001) TIRAP: An adapter molecule in the Toll signaling pathway. Nat. Immunol. 2, 835-841.