Identification and quantitative determination of a major circulating metabolite of gambogic acid in human

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 7-8, 2010, Pages 659-666

  Yang, Jing ^a   Ding, Li ^a   Jin, Shaohong ^b   Liu, Xiaoxue ^a   Liu, Wenyuan ^a   Wang, Zhenzhong ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Biological Products   (China)

^c JIANGSU KANION PHARMACEUTICAL CO   (China)

Author keywords

10 Hydroxygambogic acid; Gambogic acid; Liquid chromatography; Mass spectrometry; Metabolite

Indexed keywords

10-HYDROXYGAMBOGIC ACID; AMMONIUM ACETATE; ANALYTES; CALIBRATION CURVES; ETHYL ACETATES; GAMBOGIC ACID; HUMAN PLASMAS; INTERNAL STANDARDS; INTRAVENOUS INJECTIONS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; MASS SPECTRA; MOBILE PHASE; QUANTIFICATION METHODS; QUANTITATIVE DETERMINATIONS; REFERENCE STANDARD; RETENTION TIME; SENSITIVE METHOD; SINGLE-QUADRUPOLE MASS SPECTROMETERS; WATER SOLUTIONS;

ACETONITRILE; AMMONIUM COMPOUNDS; BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; ESTERS; FORMIC ACID; GENETIC ALGORITHMS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; ORGANIC ACIDS; RESINS; SOLVENT EXTRACTION; STANDARDS;

LIQUIDS;

10 HYDROXYGAMBOGIC ACID; ACETIC ACID ETHYL ESTER; ACETONITRILE; DRUG METABOLITE; FORMIC ACID; GAMBOGIC ACID; GLYCYRRHETINIC ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG STRUCTURE; ELECTROSPRAY; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANALYSIS OF VARIANCE; ANIMALS; BILE; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; XANTHONES;

GARCINIA HANBURYI; GARCINIA MORELLA; RATTUS;

EID: 76549105946     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.01.032     Document Type: Article

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