Identification of the metabolites of ecabet bismuth in rat bile by liquid chromatography-electrospray ionization-tandem mass spectrometry

European Journal of Mass Spectrometry

Volumn 15, Issue 4, 2009, Pages 531-539

  Wu, Yue ^a   Yang, Jing ^a   Ding, Li ^a   Xu, Guili ^b   Qian, Wenjuan ^a   Yun, Changhong ^a   He, Jianchang ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b KUNMING GENERAL HOSPITAL   (China)

Author keywords

CID; Ecabet; Ecabet bismuth; LC ESI MS MS; Metabolism; Metabolite; RDA fragmentation; Structural identification; Tricyclic diterpene carboxylic acid

Indexed keywords

ABIETANE DERIVATIVE; ANTIULCER AGENT; ECABET;

ANIMAL; ARTICLE; BILE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; LIQUID CHROMATOGRAPHY; MALE; METABOLISM; METHODOLOGY; RAT; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTI-ULCER AGENTS; BILE; CHROMATOGRAPHY, LIQUID; DITERPENES, ABIETANE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 67650989229     PISSN: 14690667     EISSN: None     Source Type: Journal    
DOI: 10.1255/ejms.1006     Document Type: Article

References (23)

1. Tanabe Seiyaku Co., Ltd, Tanabe Annual Report, October [1994).
2. G. Monteleone and F. Caprioli, "Drug evaluation: TA-2711E in the treatment of active distal ulcerative colitis", Curr. Opin. Investig. Drugs 8(5), 423-428 (2007).
3. K. Shibata, Y. Ito, A. Hongo, A. Yasoshima, T. Endo and M. Ohashi, "Bacterial activity of a new antiulcer agent, ecabet sodium, against Helicobacter pylori under acidic conditions", Antimicrob. Agents Chemother. 39(6), 1295-1299(1995).
4. Y. Ito, K. Shibata, A. Hongo and M. Kinoshita, "Ecabet sodium, a locally acting antiulcer drug, inhibits urease activity of Helicobacter pylori", Eur. J. Pharmacol. 345(2), 193-198 (1998). dot: 10.1016/S0014-2999(97)01622-1
5. K. Mitsuyama, N. Tomiyasu, J. Masuda, H. Yamasaki, O. Tsuruta and M. Sata, "High affinity of ecabet sodium for inflamed colonic mucosa in ulcerative colitis", Dig. Dis. Sci. 52(6), 1442-1443 (2007). doi: 10.1007/s10620-006-9587-1
6. J.H. Lee, J.J. Kin, K.B. Hahm, D.H. Lee, N. Kin, S.K. Kin, J.J. Prak, S.R. Choi, J.H. Lee, ST. Lee, E.H. Lee and J.C. Rhee, "Efficacy and safety of ecabet sodium on functional dyspepsia: a prospective, double-blinded, randomized, multi-center controlled trial", World J. Gastroenterol. 12(17), 2756-2761 (2006).
7. K. Okuyama, N. Saito, E. Kume, T. Noto and M. Nagasaki, "Ecabet sodium prevents esophageal lesions induced by the reflux of gastric juice in rats", Inflammopharmacology 15(2), 90-94 (2007). doi: 10.1007/ S10787-006-1538-0
8. Y. Ito, T. Fukushima, Y. Sugawara, O. Takaiti and S. Nakamura, "Metabolic fate of a new anti-ulcer drug (+)-(1R, 4aS, 10aR)-1. 2, 3, 4, 4a, 9, 10, 10a-octahydro-1, 4a-dimethyl-7-(1-methylethyl)-6-sulfo-1- phenanthrene-carboxylic acid 6-sodium salt pentahydrate (TA-2711). I. Disposition, metabolism and protein binding in rats and dogs", J. Pharmacobiodyn. 14(9), 533-546 (1991).
9. Y. Ito, Y. Sugawara, O. Takaiti and S. Nakamura, "Metabolic fate of a new anti-ulcer drug 1+]-(1R, 4aS, 10aR)-1. 2, 3, 4, 4a, 9, 10, 10a-octahydro-1, 4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic acid 6-sodium salt pentahydrate (TA-2711). II. Distribution in the rat stomach", J. Pharmacobiodyn. 14(9),547-554(1991).
10. S.A. Chan, M.J. Chen, T.Y. Liu, M.R. Fuh, J.F. Deng, M.L. Wu and S.J. Hsieh, "Determination of aristolochic acids in medicinal plant and herbal product by liquid chromatography-electrospray-ion trap mass spectrometry", Talanta 60, 679-685 (2003). doi: 10.1016/S0039-9140(03)00142-5
11. X. Yu, D. Cui and M.R. Davis, "Identification of in vitro metabolites of indinavir by 'intelligent automated LC-MS/MS' (INTAMS) utilizing triple quadrupole tandem mass spectrometry", J. Am. Soc. Mass Spectrom. 10, 175-183 (1999). doi: 10.1016/S1044-0305(98)00132-9
12. W. Lam and R. Ramanathan, "In electrospray ionization source hydrogen/deuterium exchange LC-MS and LC-MS/MS for characterization of metabolites", J. Am. Soc. Mass Spectrom. 13, 345-353 (2002). doi: 10.1016/ S1044-0305(02)00346-X
13. M. Holcapek, L. Kolarova and M. Nobilis, "High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites", Anal. Bioanal. Chem. 391, 59-78 (2008). doi: 10.1007/S00216-008-1962-7
14. E. Gangl, H. Utkin, N. Gerberand P. Vouros, "Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry", J. Chromatogr. A 974, 91-101 (2002). doi: 10.1016/S0021-9673(02)01243-8
15. Z.H. Peng, W. Song, F.M. Han, H.X. Chen, M.M. Zhu and Y. Chen, "Chromatographic tandem mass spectrometric detection of papaverine and its major metabolites in rat urine", Int. J. Mass Spectrom. 266, 114-121 (2007). doi: 10.1016/j.ijms. 2007.07.013
16. G.H. Mulder, E. Scholtens and D. Meuer, "Collection of metabolites in bile and urine from rat", Methods Enzymol 77, 21-30 (1981). doi: 10.1016/S0076-6879(81)77006-X
17. L. Ren, K.S. Bi, P. Gong, W.M. Cheng, Z. Song, L. Fang and X.H. Chen, "Characterization of in vivo and in vitro metabolic profile of PAC-1 using liquid chromatography-mass spectrometry", J. Chromatogr. B 876, 47-53 (2008). doi:10.1016/j.jchromb.2008.10.006
18. J.Y. Pan and Y.Y. Cheng, "Identification and analysis of absorbed and metabolic components in rat plasma after oral administration of 'Shuangdan' granules by HPLC-DAD-ESI-MS/MS", J. Pharm. Biomed. Anal. 42, 565-572 (2006). doi: 10.1016/j.jpba.2006.05.006
19. D. Zhang, X.L Du, M.Y. Liu, H. Li, Y. Jiang, LM. Zhao and J.K. Gu, "Determination of ecabet in human plasma by high-performance liquid chromatography-tandem mass spectrometry", J. Chromatogr. B 863, 223-228 (2008). doi:10.1016/j.jchromb.2008.01.013
20. M.L. Proefke and K.L. Rinehart, "Analysis of an Egyptian mummy resin by mass spectrometry", J. Am. Soc. Mass Spectrom. 3, 582-589 (1992). doi: 10.1016/1044-0305(92)85036-J
21. Z.C. Zhang, M. Xu, S.F. Sun, X. Qiao, B.R. Wang, J. Han and D.A. Guo, "Metabolic analysis of four phenolic acids in rat by liquid chromatography-tandem mass spectrometry", J. Chromatogr. B 871, 7-14 (2008). doi: 10.1016/j.jchromb.2008.06.019
22. n", J. Pharm. Biomed. Anal. 48, 885-896 (2008). doi: 10.1016/j. jpba.2008.07.011
23. J.P. Uetrecht and W. Trager, Drug Metabolism: Chemical and Enzymatic Aspects, Informa Healthcare USA, Inc., New York, USA, p. 71 (2007).