Identification and analysis of absorbed and metabolic components in rat plasma after oral administration of 'Shuangdan' granule by HPLC-DAD-ESI-MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 42, Issue 5, 2006, Pages 565-572

  Pan, Jian Yang ^a   Cheng, Yi Yu ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

'Shuangdan' granule; Absorbed and metabolic components; High performance liquid chromatography ion trap mass spectrometry; Rat plasma

Indexed keywords

2 HYDROXY 4 METHOXYACETOPHENONE 5 O SULFATE; 2,4 DIHYDROXYACETOPHENONE 5 O SULFATE; 3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; 4 HYDROXYACETOPHENONE 2 O GLUCURONIDE; ACETIC ACID; ACETIC ACID ETHYL ESTER; ACETONITRILE; CAFFEIC ACID; CHINESE DRUG; CRYPTOTANSHINONE; DIHYDROTANSHINONE I; DRUG METABOLITE; GALLIC ACID; HYDROCHLORIC ACID; LITHOSPERMIC ACID; NEOCRYPTOTANSHINONE; PAEONIFLORIN; PAEONOL 2 O GLUCURONIDE; PEONOL; PLANT EXTRACT; PROTOCATECHUALDEHYDE; RESACETOPHENONE; ROSMARIMIC ACID; SALVIANOLIC ACID B; SALVIANOLIC ACID C; SALVIANOLIC ACID D; SALVIANOLIC ACID G; SHUANGDAN; TANSHINONE V; UNCLASSIFIED DRUG; WATER;

ACIDIFICATION; ANALYTIC METHOD; ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DIODE; DRUG ABSORPTION; DRUG FORMULATION; DRUG GRANULE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG RETENTION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION TRAP MASS SPECTROMETRY; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

ACETOPHENONES; ADMINISTRATION, ORAL; ADSORPTION; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; MALE; MEDICINE, CHINESE TRADITIONAL; PHENANTHRENES; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 33750341684     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.05.006     Document Type: Article

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