Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress

British Journal of Haematology

Volumn 148, Issue 5, 2010, Pages 714-725

  Uckun, Fatih M ^a,b,c   Ozer, Zahide ^b,c   Qazi, Sanjive ^c,d   Tuel Ahlgren, Lisa ^c   Mao, Chen ^e  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c PARKER HUGHES INSTITUTE   (United States)

^d GUSTAVUS ADOLPHUS COLLEGE   (United States)

^e Biology Department   (United States)

Author keywords

Chemotherapy resistance; Leukaemia; Oxidative stress; Radiation resistance; Tyrosine kinase

Indexed keywords

2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHOXY)PHENYL]CROTONAMIDE; 2 CYANO N (2,5 DIBROMOPHENYL) 3 HYDROXYCROTONAMIDE; 4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANTINEOPLASTIC AGENT; CLADRIBINE; CYTARABINE; ETOPOSIDE; LEFLUNOMIDE; METHOTREXATE; POLO LIKE KINASE 1; PROTEIN KINASE SYK; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER SURVIVAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RADIATION DOSE; RADIOSENSITIVITY; SCHOOL CHILD; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; WHOLE BODY RADIATION;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CHILD; ENZYME ACTIVATION; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MODELS, MOLECULAR; OXIDATIVE STRESS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; YOUNG ADULT; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 76449113601     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07983.x     Document Type: Article

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