Anti-inflammatory activity of 2,4,6-trihydroxy-α-p-methoxyphenylacetophenone (compound D-58)

Dermatology

Volumn 201, Issue 4, 2000, Pages 337-342

  Malaviya, Rama ^a   Malaviya, Ravi ^a   Uckun, Fatih M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

Antioxidant; Inflammation; Prostaglandin E2; Tyrosine kinases; UVB light

Indexed keywords

2,4,6 TRIHYDROXY ALPHA 4 METHOXYPHENYLACETOPHENONE; CARRAGEENAN; COMPOUND D 58; GENISTEIN; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; EPIDERMIS CELL; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; SKIN EDEMA; SKIN INFLAMMATION; ULTRAVIOLET B RADIATION;

ACETOPHENONES; ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL LINE; DINOPROSTONE; EDEMA; FEMALE; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED BALB C; PROTEIN-TYROSINE KINASES; SKIN; ULTRAVIOLET RAYS;

EID: 0034524734     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000051549     Document Type: Article

References (36)

1. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation: A mechanism for irradiation erythema
2. Mechanisms of UV-induced inflammation
3. Delayed manifestation of ultraviolet reaction in the guinea-pig caused by anti-inflammatory drugs
4. 2alpha in human skin at 6 and 24 h after ultraviolet B irradiation (290-320 nm)
5. 2alpha in human skin following ultraviolet B irradiation
6. Prostanoid biosynthesis and mechanisms of action
7. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2
8. An in vitro model to test relative antioxidant potential: Ultraviolet-induced lipid peroxidation in liposomes
9. Free radicals in human skin before and after exposure to light
10. Studies on the role of reactive oxygen species in mediating lipid peroxide formation in epidermal microsomes of rat skin
11. 2
12. NF-kappa B activation by ultraviolet light not dependent on a nuclear signal
13. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
14. The role of human papillomavirus in the development of pyogenic granulomas
15. In vivo antioxidant activity of genistein in a murine model of singlet oxygen-induced cerebral stroke
16. Histamine in human epidermal cells is induced by ultraviolet light injury
17. Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide]
18. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents
19. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells
20. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex
21. Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases
22. Responses of normal skin to ultraviolet radiation
23. The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine
24. A role for endogenous histamine in interleukin-8-induced neutrophil infiltration into mouse air-pouch: Investigation of the modulatory action of systemic and local dexamethasone
25. Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes
26. Prevention of ultraviolet damage to the dermis of hairless mice by sunscreens
27. A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse
28. New concepts about the mast cell
29. Topical indomethacin and sunburn
30. 1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol
31. Functions of Bruton's tyrosine kinase in mast and B cells
32. Redundant and opposing functions of two tyrosine kinases, btk and lyn, in mast cell activation
33. Syk kinase, tyrosine-phosphorylated proteins and actin filaments accumulate at forming phagosomes during Fcgamma receptor-mediated phagocytosis
34. The syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils
35. Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein
36. syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction