Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: Implications for understanding troglitazone hepatotoxicity

Drug Metabolism and Disposition

Volumn 32, Issue 3, 2004, Pages 291-294

  Nozawa, Takashi ^a,b   Sugiura, Shigeki ^c   Nakajima, Miki ^b   Goto, Akihiko ^a   Yokoi, Tsuyoshi ^b   Nezu, Jun Ichi ^d   Tsuji, Akira ^b   Tamai, Ikumi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

^d CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BILE ACID; BILIRUBIN; ESTRONE SULFATE; ORGANIC ANION TRANSPORTER; PIOGLITAZONE; ROSIGLITAZONE; TROGLITAZONE;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; HUMAN; HUMAN CELL; LIVER TOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; XENOPUS;

BIOLOGICAL TRANSPORT, ACTIVE; CHROMANS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ESTRONE; HEPATITIS, TOXIC; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; MOLECULAR SEQUENCE DATA; OOCYTES; ORGANIC ANION TRANSPORTERS; PROTEIN BINDING; QUINONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIAZOLIDINEDIONES;

ANIMALIA;

EID: 1342302280     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.3.291     Document Type: Article

References (18)

1. Funk C, Ponelle C, Scheuermann G, and Pantze M (2001) Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol Pharmacol 59:627-635.
2. Gitlin N, Julie NL, Spurr CL, Lim KL, and Juarbe HM (1998) Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone. Ann Intern Med 129:36-38.
3. Hagenbuch B and Meier PJ (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609:1-18.
4. Kawai K, Hirota T, Muramatsu S, Tsuruta F, Ikeda T, Kobashi K, and Nakamura KI (2000) Intestinal absorption and excretion of troglitazone sulphate, a major biliary metabolite of troglitazone. Xenobiotica 30:707-715.
5. Kawai K, Kawasaki-Tokui Y, Odaka T, Tsuruta F, Kazui M, Iwabuchi H, Nakamura T, Kinoshita T, Ikeda T, Yoshioka T, et al. (1997) Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs. Arzneim-Forsch 47:356-368.
6. Kostrubsky VE, Sinclair JF, Ramachandran V, Venkataramanan R, Wen YH, Kindt E, Galchev V, Rose K, Sinz M, and Strom SC (2000) The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures. Drug Metab Dispos 28:1192-1197.
7. Kostrubsky VE, Vote M, Kindt E, Burliegh J, Rogers K, Peter G, Altrogge D, and Sinz MW (2001) The effect of troglitazone biliary excretion on metabolite distribution and cholestasis in transporter-deficient rats. Drug Metab Dispos 29:1561-1566.
8. Loi CM, Randinitis EJ, Vassos AB, Kazierad DJ, Koup JR, and Sedman AJ (1997) Lack of effect of type II diabetes on the pharmacokinetics of troglitazone in a multiple-dose study. J Clin Pharmacol 37:1114-1120.
9. Loi CM, Young M, Randinitis E, Vassos A, and Koup JR (1999) Clinical pharmacokinetics of troglitazone. Clin Pharmacokinet 37:91-104.
10. Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, and Konig J (2002) A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J Biol Chem 277: 43058-43063.
11. Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J-I, Sai Y, Tsuji A, and Yokoi T (2002) Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J Pharmacol Exp Ther 302:804-813.
12. 5]-enkephalin. J Pharm Pharmacol 55:1013-1020.
13. Ott P, Ranek L, and Young MA (1998) Pharmacokinetics of troglitazone, a PPAR-γ agonist, in patients with hepatic insufficiency. Eur J Clin Pharmacol 54:567-571.
14. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, and Tsuji A (2000) Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273:251-260.
15. Tamai I, Nozawa T, Koshida M, Nezu J-I, Sai Y, and Tsuji A (2001) Functional characterization of human organic anion transporting polypeptide OATP-B in comparison with liver-specific OATP-C. Pharm Res (NY) 18:1262-1269.
16. Tirona RG, Leake BF, Merino G, and Kim RB (2001) Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J Biol Chem 276:35669-35675.
17. Watanabe Y, Nakajima M, and Yokoi T (2002) Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos 30:1462-1469.
18. Yamamoto Y, Nakajima M, Yamazaki H, and Yokoi T (2001) Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells. Life Sci 70:471-482.