Evolution of genetic redundancy

Nature

Volumn 388, Issue 6638, 1997, Pages 167-170

  Nowak, Martin A ^a   Boerlijst, Maarten C ^a   Cooke, Jonathan ^b   Smith, John Maynard ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; EVOLUTION; GENE MUTATION; GENE REPRESSION; GENE STRUCTURE; GENOME; NUCLEOTIDE REPEAT; PRIORITY JOURNAL;

ANIMALS; EVOLUTION, MOLECULAR; GENES; GENOTYPE; MODELS, GENETIC; SELECTION (GENETICS);

EID: 0030836756     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/40618     Document Type: Article

References (30)

1. Brookfield, J. F. Y. Genetic redundancy. Adv. Genet. 36, 137-155 (1997).
2. Brookfield, J. F. Y. Can genes be truly redundant? Curr. Biol. 2, 553-554 (1992).
3. Tautz, D. Redundancies, development and the flow of information. BioEssays 14, 263-266 (1992).
4. Goldstein, D. B. & Holsinger, K. E. Maintenance of polygenic variation in spatially structured populations. Evolution 46, 412-429 (1992).
5. Thomas, J. H. Thinking about genetic redundancy. Trends Genet. 9, 395-399 (1993).
6. Dover, G. A. Evolution of genetic redundancy for advanced players. Curr. Opin. Genet. Dev. 3, 902-910 (1993).
7. Pickett, F. B. & Meeks-Wagner, D. R. Seeing double: appreciating genetic redundancy. Plant Cell 7, 1347-1356 (1995).
8. Bird, A. P. Gene number, noise reduction and biological complexity. Trends Genet. 11, 94-100 (1995).
9. O'Brien, S. J. On estimating function gene number in eukaryotes. Nature New Biol. 242, 52-54 (1973).
10. Kastner, P. et al. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83, 859-869 (1995).
11. Rudnicki, M. A. et al. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development Cell 71, 383-390 (1992).
12. Saga, Y. et al. Mice develop normally without tenascin. Genes Dev. 6, 1821-1831 (1992).
13. Yang, Y. et al Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature 379, 823-825 (1996).
14. Joyner, A. L. et al. Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 251, 1239-1243 (1991).
15. Laney, J. D. & Biggin, M. D. Redundant control of Ultrabithorax by zeste involves functional levels of zeste protein binding at the Ultrabithorax promoter. Development 122, 2303-2311 (1996).
16. Schorle, H. et al. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352, 621-624 (1991).
17. Taniguchi, T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268, 251-255 (1995).
18. Steindler, D. A. et al. Tenascin Knockout Mice: Barrels, Boundary Molecules, and Glial Scars. J. Neurosci. 15, 1971-1983 (1995).
19. Pekny, M. et al. Mice lacking glial fibrallary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally. EMBO J. 14, 1590-1598 (1995).
20. Reed, S. I. G1-specific cyclins in search of an S-phase promoting factor Trends Genet. 7, 95-99 (1991).
21. Roche, S. et al. Requirement for Src family protein tyrosine kinases in G-2 for fibroblast cell division. Science 269, 1567-1569 (1995).
22. Fisher, R. A. The sheltering of lethals. Am. Nat. 69, 446-455 (1935).
23. Christiansen, F. B. & Frydenberg, O. Selection-mutation balance for two nonallelic recessives producing an inferior double homozygote. Am. J. Hum. Genet. 29, 195-207 (1977).
24. Bailey, G. S. et al. Gene duplication in tetraploid fish: model for gene silencing at unlinked loci. Proc. Natl Acad. Sci USA 75, 5575-5579 (1978).
25. Allendorf, F. W. Protein polymorphism and the rate of loss of duplicate gene expression. Nature 272, 76-78 (1978).
26. Kimura, M. & King, J. L. Fixation of a deleterious allele at one of two duplicate loci by mutation pressure and random drift. Proc. Natl. Acad. Sci. USA 76, 2858-2861 (1979).
27. Li, W.-H. Rate of gene silencing at duplicate loci: a theoretical study and interpretation of data from tetraploid fish. Genetics 95, 237-258 (1980).
28. Ohta, T. Time for spreading of compensatory mutations under gene duplication. Genetics 123, 579-584 (1989).
29. Li, X. & Noll, M. Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis- regulatory regions. Nature 367, 83-87 (1994).
30. Krakauer, D. C. & Pagel, M. Selection by somatic signals. Phil. Trans. R. Soc. Land. B 351, 647-658 (1996).