Differential role of the Fas/Fas ligand apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome1

Journal of Immunology

Volumn 183, Issue 12, 2009, Pages 8244-8257

  Lopez, Andrea D ^a   Avasarala, Sreedevi ^b   Grewal, Suman ^a,b   Murali, Anuradha K ^a   London, Lucille ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8 INHIBITOR; FAS LIGAND; AUTACOID; FAS ANTIGEN;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MAMMALIAN ORTHOREOVIRUS; MOUSE; NICK END LABELING; NONHUMAN; PNEUMONIA; POINT MUTATION; PRIORITY JOURNAL; REOVIRUS; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CBA MOUSE; COMPARATIVE STUDY; FEMALE; GENETICS; IMMUNOLOGY; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; VIROLOGY;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; FAS LIGAND PROTEIN; FEMALE; INFLAMMATION MEDIATORS; MICE; MICE, INBRED CBA; MICE, TRANSGENIC; ORTHOREOVIRUS, MAMMALIAN; PULMONARY FIBROSIS; RESPIRATORY DISTRESS SYNDROME, ADULT; SIGNAL TRANSDUCTION;

EID: 76249121816     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901958     Document Type: Article

References (88)

1. Cooper, J. A., Jr. 2000. Pulmonary fibrosis: pathways are slowly coming into light. Am. J. Resp. Cell. Mol. Biol. 22: 520-523.
2. Kuwano, K., N. Hagimoto, and N. Hara. 2001. Molecular mechanisms of pulmonary fibrosis and current treatment. Curr. Mol. Med. 1: 551-573. (Pubitemid 33772035)
3. Katzenstein, A. L., S. Mukhopadhyay, and J. L. Myers. 2008. Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases. Hum. Pathol. 39: 1275-1294.
4. Afshar, K., and O. P. Sharma. 2008. Interstitial lung disease: trials and tribulations. Curr. Opin. Pulm. Med. 14: 427-433.
5. Drakopanagiotakis, F., V. Polychronopoulos, and M. A. Judson. 2008. Organizing pneumonia. Am. J. Med. Sci. 335: 34-39.
6. Ware, L. B., and M. A. Matthay. 2000. The acute respiratory distress syndrome. N. Engl. J. Med. 342: 1334-1349.
7. Epler, G. R., T. V. Colby, T. C. McLoud, C. B. Carrington, and E. A. Gaensler. 1985. Bronchiolitis obliterans organizing pneumonia. N. Engl. J. Med. 312: 152-158.
8. Epler, G. R. 1992. Bronchiolitis obliterans organizing pneumonia: definition and clinical features. Chest 102(Suppl.): 2S-6S.
9. Colby, T. V. 1992. Pathologic aspects of bronchiolitis obliterans organizing pneumonia. Chest 102(Suppl.): 38S-43S.
10. Epler, G. R. 2001. Bronchiolitis obliterans organizing pneumonia. Arch. Int. Med. 161: 158-164.
11. Schlesinger, C., and M. N. Koss. 2005. The organizing pneumonias: an update and review. Curr. Opin. Pulm. Med. 11: 422-430.
12. Cordier, J. F. 2006. Cryptogenic organising pneumonia. Eur. Respir. J. 28: 422-446.
13. Corrin, B. 2000. Diffuse alveolar damage, the pathological basis of adult respiratory distress syndrome. In Pathology of the Lung. B. Corrin, ed. Churchill Livingstone, London, pp. 121-143.
14. Piantadosi, C. A., and D. A. Schwartz. 2004. The acute respiratory distress syndrome. Ann. Intern. Med. 41: 460-470.
15. Castro, C. Y. 2006. ARDS and diffuse alveolar damage: a pathologist's perspective. Semin. Thorac. Cardiovasc. Surg. 18: 13-19.
16. Wheeler, A. P., and G. R. Bernard. 2007. Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 369: 1553-1564. (Pubitemid 46670280)
17. Ware, L. B. 2007. Clinical year in review III: asthma, lung transplantation, cystic fibrosis, acute respiratory distress syndrome. Proc. Am. Thorac. Soc. 4: 489-493.
18. Fukuda, Y., M. Ishizaki, Y. Masuda, G. Kimura, O. Kawanami, and Y. Masugi. 1987. The role of intra-alveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage. Am. J. Pathol. 126: 171-181. (Pubitemid 17007963)
19. Bellum, S. C., D. Dove, R. A. Harley, W. B. Greene, M. A. Judson, L. London, and S. D. London. 1997. Respiratory reovirus 1/L induction of intraluminal fibrosis: a model for the study of bronchiolitis obliterans organizing pneumonia. Am. J. Pathol. 150: 2243-2254.
20. London, L., E. I. Majeski, M. K. Pantilia, R. A. Harley, and S. D. London. 2002. Respiratory reovirus 1/L induction of diffuse alveolar damage: a model of acute respiratory distress syndrome. Exp. Mol. Pathol. 72: 24-36. (Pubitemid 34948279)
21. London, L., E. I. Majeski, S. Altman-Hamamdzic, C. Enockson, M. K. Pantilia, R. A. Harley, and S. D. London. 2002. Respiratory reovirus 1/L induction of diffuse alveolar damage: pulmonary fibrosis is not modulated by corticosteroids in acute respiratory distress syndrome in mice. Clin. Immunol. 103: 284-295. (Pubitemid 34666752)
22. Majeski, E. I., R. A. Harley, S. Bellum, S. D. London, and L. London. 2003. Differential role for T cells in the development of fibrotic lesions associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia versus acute respiratory distress syndrome. Am. J. Respir. Cell Mol. Biol. 28: 208-217.
23. Majeski, E. I., M. K. Paintlia, A. D. Lopez, R. A. Harley, S. D. London, and L. London. 2003. Respiratory reovirus 1/L induction of intraluminal fibrosis, a model of bronchiolitis obliterans organizing pneumonia, is dependent on T lymphocytes. Am. J. Pathol. 63: 1467-1479.
24. Elmore, S. 2007. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 35: 495-516. (Pubitemid 46911891)
25. Lu, Q., E. O. Harrington, and S. Rounds. 2005. Apoptosis and lung injury. Keio J. Med. 54: 184-189.
26. Martin, T. R., N. Hagimoto, M. Nakamura, and G. Matute-Bello. 2005. Apoptosis and epithelial injury in the lungs. Proc. Am. Thorac. Soc. 2: 214-220.
27. de Souza, P. M., and M. A. Lindsay. 2005. Apoptosis as a therapeutic target for the treatment of lung disease. Curr. Opin. Pharmacol. 5: 232-137.
28. Li, X., R. Shu, G. Filippatos, and B. D. Uhal. 2004. Apoptosis in lung injury and remodeling. J. Appl. Physiol. 97: 1535-1542.
29. Kuwano, K., N. Hagimoto, M. Kawasaki, T. Yatomi, N. Nakamura, S. Nagata, T. Suda, R. Kunitake, T. Maeyama, H. Miyazaki, and N. Hara. 1999. Essential roles for the Fas-Fas ligand pathways in the development of pulmonary fibrosis. J. Clin. Invest. 104: 13-19. (Pubitemid 29534340)
30. Kuwano, K., H. Miyazaki, N. Hagimoto, M. Kawasaki, M. Fujita, R. Kunitake, Y. Kaneko, and N. Hara. 1999. The involvement of Fas-Fas ligand pathway in fibrosing lung diseases. Am. J. Respir. Cell Mol. Biol. 20: 53-60. (Pubitemid 129504842)
31. Kuwano, K., N. Hagimoto, T. Tanaka, M. Kawasaki, R. Kunitake, H. Miyazaki, Y. Kaneko, T. Matsuba, T. Maeyama, and N. Hara. 2000. Expression of apoptosis regulatory genes in epithelial cells in pulmonary fibrosis in mice. J. Pathol. 190: 221-229. (Pubitemid 30082497)
32. Matute-Bello, G., W. C. Liles, K. P. Steinberg, P. A. Kiener, S. Mongovin, E. Y. Chi, M. Jonas, and T. R. Martin. 1999. Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury. J. Immunol. 163: 2217-2225.
33. Kitamura, Y., S. Hashimoto, N. Mizuta, A. Kobayashi, K. Kooguchi, I. Fujiwara, and H. Nakajima. 2001. Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice. Am. J. Respir. Crit. Care Med. 163: 762-769.
34. Wang, H. C., C. T. Shun, S. M. Hsu, S. H. Kuo, K. T. Luh, and P. C. Yang. 2002. Fas/Fas ligand pathway is involved in the resolution of type II pneumocyte hyperplasia after acute lung injury: evidence from a rat model. Crit. Care Med. 30: 1528-1534.
35. Hansen, P. R., A. M. Holm, U. G. Svendsen, P. S. Olsen, and C. B. Andersen. 2000. Apoptosis and formation of peroxynitrite in the lungs of patients with obliterans bronchiolitis. J. Heart Lung Transplant. 19: 160-166.
36. Kuwano, K., M. Kawasaki, T. Maeyama, N. Hagimoto, N. Nakamura, K. Shirakawa, and N. Hara. 2000. Soluble form of Fas and Fas ligand in BAL fluid from patients with pulmonary fibrosis and bronchiolitis obliterans organizing pneumonia. Chest 118: 451-458.
37. Lappi-Blanco, E., Y. Soini, and P. Paakko. 1999. Apoptotic activity is increased in the newly formed fibromyxoid connective tissue in bronchiolitis obliterans organizing pneumonia. Lung 177: 367-376.
38. cg that complements the gld gene in induction of lymphadenopathy in the mouse. J. Exp. Med. 171: 519-531.
39. Bajt, M. L., J. A. Lawson, S. L. Vonderfecht, J. S. Gujral, and H. Jaeschke. 2000. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a post-mitochondrial processing of caspase-8. Toxicol. Sci. 58: 109-117.
40. Bajt, M. L., S. L. Vonderfecht, and H. Jaeschke. 2001. Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis. Toxicol. Appl. Pharmacol. 175: 243-252.
41. Kawasaki, M., K. Kuwano, N. Hagimoto, T. Matsuba, R. Kunitake, T. Tanaka, T. Maeyama, and N. Hara. 2000. Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor. Am. J. Pathol. 157: 597-603. (Pubitemid 30626918)
42. Wang, R., O. Ibarra-Sunga, L. Verlinski, R. Pick, and U. D. Uhal. 2000. Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am. J. Physiol. 279: L143-L151.
43. Kuwano, K., R. Kunitake, T. Maeyama, N. Hagimoto, M. Kawasaki, T. Matsuba, M. Yoshimi, I. Inoshima, K. Yoshida, and N. Hara. 2001. Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor. Am. J. Physiol. 280: L316-L325. (Pubitemid 33773566)
44. Hotchkiss, R. S., K. C. Chang, P. E. Swanson, K. W. Tinsley, J. J. Hui, P. Klender, S. Xanthoudakis, S. Roy, C. Black, E. Grimm, et al. 2000. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat. Immunol. 1: 496-501.
45. Hotchkiss, R. S., K. W. Tinsley, P. E. Swanson, K. C. Chang, J. P. Cobb, T. G. Buchman, S. J. Korsmeyer, and I. E. Karl. 1999. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc. Natl. Acad. Sci. USA 96: 14541-14546.
46. Malkusch, W., B. Rehn, and J. Bruch. 1995. Advantages of Sirius red staining for quantitative morphometric collagen measurements in lungs. Exp. Lung Res. 21: 67-77.
47. Bohinski, R. J., R. DiLauro, and J. A. Whitsett. 1994. The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol. Cell. Biol. 14: 5671-5681.
48. deFelice, M., D. Silberschmidt, R. DiLauro, Y. Xu, S. E. Wert, T. E. Weaver, C. J. Bachurski, J. C. Clark, and J. A. Whitsett. 2003. TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J. Biol. Chem. 278: 35574-35583.
49. Antoniou, K. M., A. Pataka, D. Bouros, and N. M. Siafakas. 2007. Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis. Pulm. Pharmacol. Ther. 20: 453-461.
50. Uhal, B. D. 2003. Epithelial apoptosis in the initiation of lung fibrosis. Eur. Respir. J. 44: 7S-9S.
51. Mecklenburgh, K., J. Murray, T. Brazil, C. Ward, A. G. Rossi, and E. R. Chilvers. 1999. Role of neutrophil apoptosis in the resolution of pulmonary inflammation. Monaldi Arch. Chest Dis. 54: 345-349. (Pubitemid 29488354)
52. Hashimoto, S., A. Kobayashi, K. Kooguchi, Y. Kitamura, H. Onodera, and H. Nakajima. 2000. Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 161: 237-243. (Pubitemid 30055931)
53. Maeyama, M., K. Kuwano, M. Kawasaki, R. Kunitaki, N. Hagimoto, T. Matsuba, M. Yoshimi, I. Inoshima, K. Yoshida, and N. Hara. 2001. Upregulation of Fas-signaling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis. Eur. Respir. J. 17: 180-189.
54. Barbas-Filho, J. V., M. A. Ferreira, A. Sesso, R. A. Kairalla, C. R. R. R. Carvalho, and V. L. Capelozzi. 2001. Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis and usual interstitial pneumonia. J. Clin. Pathol. 54: 132-138.
55. Thannickal, V. J., and J. C. Horowitz. 2006. Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc. Am. Thorac. Soc. 3: 350-356. (Pubitemid 43845412)
56. Albertine, K. H., M. F. Soulier, Z. Wang, A. Ishizaka, S. Hashimoto, G. A. Zimmerman, M. A. Matthay, and L. B. Ware. 2002. Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am. J. Pathol. 161: 1783-1796.
57. Nakamura, M., G. Matute-Bello, W. C. Liles, S. Hayashi, O. Kajikawa, S. M. Lin, C. W. Frevert, and T. R. Martin. 2004. Differential response of human lung epithelial cells to fas-induced apoptosis. Am. J. Pathol. 164: 1949-1958. (Pubitemid 38669344)
58. Schneider, P., N. Holler, J. L. Bodmer, M. Hahne, K. Frei, A. Fontana, and J. Tschopp. 1998. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J. Exp. Med. 187: 1205-1213.
59. Hagimoto, N., K. Kuwano, Y. Nomoto, R. Kunitake, and N. Hara. 1997. Apoptosis and expression of Fas/Fas ligand in mRNA in bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Cell Mol. Biol. 16: 91-101. (Pubitemid 127497440)
60. Aoshiba, K., S. Yasui, J. Tamaoki, and A. Nagai. 2000. The Fas/Fas-ligand system is not required for bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Crit. Care Med. 162: 695-700. (Pubitemid 30647221)
61. Golan-Gerstl, R., S. B. Wallach-Dayan, G. Amir, and R. Breuer. 2007. Epithelial cell apoptosis by fas ligand-positive myofibroblasts in lung fibrosis. Am. J. Respir. Cell Mol. Biol. 36: 270-275.
62. Neff, T. A., R. F. Guo, S. B. Neff, J. V. Sarma, C. L. Speyer, H. Gao, K. D. Bernacki, M. Huber-Lang, S. McGuire, L. M. Hoesel, et al. 2005. Relationship of acute lung inflammatory injury to Fas/FasL system. Am. J. Pathol. 166: 685-694.
63. Perl, M., C. S. Chung, U. Perl, J. Lomas-Neira, M. de Paepe, W. G. Cioffi, and A. Ayala. 2007. Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury. Am. J. Respir. Crit. Care Med. 176: 591-601. (Pubitemid 47403277)
64. Kwon, K. Y., J. H. Jang, W. I. Choi, S. Ramachandran, C. H. Cho, and P. T. Cagle. 2006. Expression of apoptotic nuclei by ultrastructural terminal deoxyribonucleotidyl transferase mediated dUTP nick end labeling and detection of FasL, caspases and PARP protein molecules in cadmium induced acute alveolar cell injury. Toxicology 218: 197-204.
65. Matsuda, N., S. Yamamoto, K. Takano, S. Kageyama, Y. Kurobe, Y. Yoshihara, Y. Takano, and Y. Hattori. 2009. Silencing of Fas-associated death domain protects mice from septic lung inflammation and apoptosis. Am. J. Respir. Crit. Care Med. 179: 806-815.
66. Beck, J. M., A. M. Preston, S. E. Wilcoxen, S. B. Morris, A. Sturrock, and R. Paine, 3rd. 2009. Critical roles of inflammation and apoptosis in improved survival in a model of hyperoxia-induced acute lung injury in Pneumocystis murina-infected mice. Infect. Immun. 77: 1053-1060.
67. Hagimoto, N., K. Kuwano, H. Miyazaki, R. Kunitake, M. Fujita, M. Kawasaki, Y. Kaneko, and N. Hara. 1997. Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen. Am. J. Respir. Cell Mol. Biol. 17: 272-278. (Pubitemid 127500830)
68. Matute-Bello, G., R. K. Winn, M. Jonas, E. Y. Chi, T. R. Martin, and W. C. Liles. 2001. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am. J. Pathol. 158: 153-161. (Pubitemid 32096480)
69. Hao, Z., B. Hampel, H. Yagita, and K. Rajewsky. 2004. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J. Exp. Med. 199: 1355-1365. (Pubitemid 38685727)
70. Matute-Bello, G., J. S. Lee, W. C. Liles, C. W. Frevert, S. Mongovin, V. Wong, K. Ballman, S. Sutlief, and T. R. Martin. 2005. Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung. J. Immunol. 175: 4069-4075. (Pubitemid 41292070)
71. Matute-Bello, G., N. M. Wurfel, J. S. Lee, D. R. Park, C. W. Frevert, D. K. Madtes, S. D. Shapiro, and T. R. Martin. 2007. Essential role of MMP-12 in Fas-induced lung fibrosis. Am. J. Respir. Cell Mol. Biol. 37: 210-221.
72. Clark, P., R. L. Debiasi, R. Goody, C. C. Hoyt, S. Richardson-Burns, and K. L. Tyler. 2005. Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunol. 18: 89-115.
73. Uhal, B. D., C. Gidea, R. Bargout, A. Bifero, O. Ibarra-Sunga, M. Papp, K. Flynn, and G. Filippatos. 1998. Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism. Am. J. Physiol. 275: L1013-1017.
74. Methot, N., J. Huang, N. Coulombe, J. P. Vaillancourt, D. Rasper, J. Tam, Y. Han, J. Colucci, R. Zamboni, S. Xanthoudakis, et al. 2004. Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics. J. Exp. Med. 199: 199-207.
75. Perl, M., C. S. Chung, J. Lomas-Neira, T. M. Rachel, W. L. Biffl, W. G. Cioffi, and A. Ayala. 2005. Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am. J. Pathol. 167: 1545-1559.
76. Budinger, G. R., G. M. Mutlu, J. Eisenbart, A. C. Fuller, A. A. Bellmeyer, C. M. Baker, M. Wilson, K. Ridge, T. A. Barrett, V. Y. Lee, and N. S. Chandel. 2006. Proapoptotic Bid is required for pulmonary fibrosis. Proc. Natl. Acad. Sci. USA 103: 4604-4609.
77. 1: role of apoptosis in fibrosis and alveolar remodeling. Proc. Am. Thorac. Soc. 3: 418-423.
78. Kang, H. R., S. J. Cho, C. G. Lee, R. J. Homer, and J. A. Elias. 2007. Transforming growth factor (TGF)-β1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. J. Biol. Chem. 282: 7723-7732.
79. Frankel, S. K., G. P. Cosgrove, S. I. Cha, C. D. Cool, M. W. Wynes, B. L. Edelman, K. K. Brown, and D. W. Riches. 2006. TNF-β sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. Am. J. Respir. Cell Mol. Biol. 34: 293-304.
80. Tanaka, T., M. Yoshimi, T. Maeyama, N. Hagimoto, K. Kuwano, and N. Hara. 2002. Resistance to Fas-mediated apoptosis in human lung fibroblast. Eur. Respir. J. 20: 359-368.
81. Moodley, Y. P., N. L. Misso, A. K. Scaffidi, M. Fogel-Petrovic, R. J. McAnulty, G. J. Lauren, P. J. Thompson, and D. A. Knight. 2003. Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs. Am. J. Respir. Cell Mol. Biol. 29: 490-498.
82. Hagimoto, N., K. Kuwano, I. Inoshima, M. Yoshimi, N. Nakamura, M. Fujita, T. Maeyama, and N. Hara. 2002. TGF-β1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells. J. Immunol. 168: 6470-6478. (Pubitemid 34620072)
83. Eigo, S., K. Hiroaki, and T. Kazunari. 2002. Identification of a caspase 3-independent role of pro-apoptotic factor Bak in TNF-α-induced apoptosis. FEBS Lett. 528: 63-99.
84. Lee, K. S., Y. H. Choi, Y. S. Kim, S. H. Baik, Y. J. Oh, S. S. Sheen, J. H. Park, S. C. Hwang, and K. J. Park. 2008. Evaluation of bronchoalveolar lavage fluid from ARDS patients with regard to apoptosis. Respir. Med. 102: 464-469.
85. Kuwano, K. 2007. Epithelial cell apoptosis and lung remodeling. Cell. Mol. Immunol. 4: 419-429.
86. Perl, M., J. Lomas-Neira, C. Chung, and A. Ayala. 2008. Epithelial cell apoptosis and neutrophil recruitment in acute lung injury: a unifying hypothesis?: what we have learned from small interfering RNAs. Mol. Med. 14: 465-475.
87. Tang, P. S., M. Mura, R. Seth, and M. Liu. 2008. Acute lung injury and cell death: how many ways can cells die? Am. J. Physiol. 294: L632-L641.
88. Vandenabeele, P., T. Vanden Berghe, and N. Festjens. 2006. Caspase inhibitors promote alternative cell death pathways. Sci. STKE 358: 44.