Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics

Journal of Experimental Medicine

Volumn 199, Issue 2, 2004, Pages 199-207

  Méthot, Nathalie ^a   Huang, JingQi ^a   Coulombe, Nathalie ^a   Vaillancourt, John P ^a   Rasper, Dita ^a   Tam, John ^a   Han, Yongxin ^a   Colucci, John ^a   Zamboni, Robert ^a   Xanthoudakis, Steven ^a   Toulmond, Sylvie ^a   Nicholson, Donald W ^a   Roy, Sophie ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Caspase 3; ICAD; Peritonitis; Spectrin; Thymocytes

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BIOLOGICAL MARKER; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE INHIBITOR; DEOXYRIBONUCLEASE; M 310; M 791; M 808; M 826; M 867; M 920; PHOSPHATIDYLSERINE; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SEPSIS; THYMOCYTE; TRANSGENE;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; FEMALE; GENES, BCL-2; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXADIAZOLES; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SPECTRIN; T-LYMPHOCYTES;

EID: 1642500084     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20031791     Document Type: Article

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