Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus

PLoS Pathogens

Volumn 5, Issue 8, 2009, Pages

  Zelinskyy, Gennadiy ^a   Dietze, Kirsten ^a   Sparwasser, Tim ^b,c   Dittmer, Ulf ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANZYME A; GRANZYME B; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 2; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR;

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; CYTOTOXIC T LYMPHOCYTE; HERPES VIRUS INFECTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INFECTION; LYMPHOCYTE; NONHUMAN; NOTE; REGULATORY T LYMPHOCYTE; RETROVIRUS; SPLEEN; VIRUS LOAD; VIRUS REPLICATION; ACUTE DISEASE; ANIMAL; ARTICLE; DISEASE MODEL; EXPERIMENTAL LEUKEMIA; FRIEND LEUKEMIA VIRUS; IMMUNOLOGY; MOUSE; RETROVIRUS INFECTION; VIROLOGY; VIRUS INFECTION;

ACUTE DISEASE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FRIEND MURINE LEUKEMIA VIRUS; LEUKEMIA, EXPERIMENTAL; MICE; RETROVIRIDAE INFECTIONS; SPLEEN; T-LYMPHOCYTES, REGULATORY; TUMOR VIRUS INFECTIONS; VIRAL LOAD;

EID: 70049108673     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000406     Document Type: Note

References (16)

1. Lund JM, Hsing L, Pham TT, Rudensky AY (2008) Coordination of early protective immunity to viral infection by regulatory T cells. Science 320: 1220-1224. (Pubitemid 351929511)
2. Nilsson J, Boasso A, Velilla PA, Zhang R, Vaccari M, et al. (2006) HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood 108: 3808-3817. (Pubitemid 44864563)
3. Ndhlovu LC, Loo CP, Spotts G, Nixon DF, Hecht FM (2008) FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. J Leukoc Biol 83: 254-262. (Pubitemid 351225605)
4. Dittmer U, He H, Messer RJ, Schimmer S, Olbrich AR, et al. (2004) Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection. Immunity 20: 293-303. (Pubitemid 38388231)
5. Belkaid Y, Rouse BT (2005) Natural regulatory T cells in infectious disease. Nat Immunol 6: 353-360. (Pubitemid 41716772)
6. Li S, Gowans EJ, Chougnet C, Plebanski M, Dittmer U (2008) Natural regulatory T cells and persistent viral infection. J Virol 82: 21-30. (Pubitemid 350309119)
7. Hasenkrug KJ, Dittmer U (2000) The role of CD4 and CD8 T cells in recovery and protection from retroviral infection: lessons from the Friend virus model. Virology 272: 244-249.
8. Zelinskyy G, Kraft AR, Schimmer S, Arndt T, Dittmer U (2006) Kinetics of CD8+ effector T cell responses and induced CD4+ regulatory T cell responses during Friend retrovirus infection. Eur J Immunol 36: 2658-2670. (Pubitemid 44608450)
9. Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204: 57-63. (Pubitemid 46148756)
10. Mayer CT, Lahl K, Loddenkemper C, Sparwasser TD (2008) Lack of Foxp3 Treg-linage marker expression in mouse epithelial cells. Wiener Klinische Wochenschrift 120: 31-32.
11. Chen GY, Chen C, Wang L, Chang X, Zheng P, et al. (2008) Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells. J Immunol 180: 5163-5166.
12. Zelinskyy G, Balkow S, Schimmer S, Werner T, Simon MM, et al. (2007) The level of friend retrovirus replication determines the cytolytic pathway of CD8+ T-cell-mediated pathogen control. J Virol 81: 11881-11890. (Pubitemid 47623820)
13. Rubio V, Stuge TB, Singh N, Betts MR, Weber JS, et al. (2003) Ex vivo identification, isolation and analysis of tumor-cytolytic T cells. Nat Med 9: 1377-1382. (Pubitemid 37466186)
14. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, et al. (2003) Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 281: 65-78.
15. He H, Messer RJ, Sakaguchi S, Yang G, Robertson SJ, et al. (2004) Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection. J Virol 78: 11641-11647. (Pubitemid 39390750)
16. Seder RA, Darrah PA, Roederer M (2008) T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8: 247-258.