Effects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetes

Diabetes, Obesity and Metabolism

Volumn 5, Issue 5, 2003, Pages 325-332

  Howes, J B ^a   Tran, D ^a   Brillante, D ^a   Howes, Laurence G ^a  

^a ST GEORGE HOSPITAL   (Australia)

Author keywords

Blood pressure; Endothelial function; Isoflavones; Red clover; Type 2 diabetes

Indexed keywords

ACARBOSE; ACETYLCHOLINE; ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTILIPEMIC AGENT; CALCIUM; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOFLAVONE; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; N(G) METHYLARGININE; NITROPRUSSIDE SODIUM; NONSTEROID ANTIINFLAMMATORY AGENT; ORAL ANTIDIABETIC AGENT; PLACEBO; PROTON PUMP INHIBITOR; SULFONYLUREA; TRIACYLGLYCEROL; VITAMIN D;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CLOVER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DIET THERAPY; DOUBLE BLIND PROCEDURE; DYSLIPIDEMIA; FEMALE; FOREARM; HUMAN; HYPERTENSION; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE;

EID: 0141540449     PISSN: 14628902     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1463-1326.2003.00282.x     Document Type: Article

References (29)

1. Imazu M, Summii K, Yamamoto H et al. Influence of type 2 diabetes mellitus on cardiovascular disease mortality: findings from the Hawaii-Los Angeles-Hiroshima study. Diabetes Res Clin Pract 2002; 57: 61-69.
2. Jandeleit-Dahm K, Cooper ME. Hypertension and diabetes. Curr Opin Nephrol Hypertens 2002; 11: 221-228.
3. Fuller JH, Stevens LK, Wang SL. Risk factors for cardiovascular mortality and morbidity: the WHO multinational study of vascular disease in diabetes. Diabetologia 2001; 44: 54-64.
4. Sader MA, Celermajer DS. Endothelial function, vascular reactivity and gender differences in the cardiovascular system. Cardiovasc Res 2002; 53: 597-604.
5. Halcox JP, Schenke WH, Zalos G et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002; 106: 653-658.
6. Schernthaner G. Cardiovascular mortality and morbidity in type 2 diabetes mellitus. Diabetes Res Clin Pract 1996; 31 (Suppl.): S3-S13.
7. Pedrinelli R, Dell'Omo G, Penno G, Mariani M. Non-diabetic microalbuminuria, endothelial dysfunction and cardiovascular disease. Vasc Med 2001; 6: 257-264.
8. Sudhir K, Jennings GL, Funder JW, Komesaroff PA. Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women. Hypertension 1996; 28: 330-334.
9. Manwaring P, Morfis L, Diamond T, Howes LG. Effects of hormone replacement therapy on ambulatory blood pressure and vascular responses in normotensive women. Blood Press 2000; 9: 1-6.
10. Wakatsuki A. Estrogen and lipoproteins. Clin Lab 2001; 47: 339-350.
11. Grady D, Herrington D, Bittner V et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and estrogen/progestin replacement study. JAMA 2002; 288: 49-57.
12. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomised controlled trial. JAMA 2002; 288: 321-333.
13. Morito K, Aomori T, Hirose T et al. Interaction of phytoestrogens with estrogen receptors alpha and beta (II). Biol Pharm Bull 2002; 25: 48-52.
14. Schmitt E, Dekant W, Stopper H. Assaying the oestrogenicity of phytoestrogens in cells of different estrogen sensitive tissues. Toxicol In Vitro 2001; 15: 433-439.
15. Squadrito F, Altavilla D, Squadrito G et al. Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats. Cardiovasc Res 2000; 45: 454-462.
16. Howes JB, Waring M, Huang L, Howes LG. Chronic pharmacokinetics of an extract of isoflavones from red clover. J Altern Complement Med 2002; 8: 135-142.
17. Groppelli A, Omboni S, Parati G, Mancia G. Evaluation of non invasive blood pressure monitoring devices SpaceLabs 90202 and 90207 versus resting and ambulatory 24-hour intra-arterial blood pressure. Hypertension 1992; 20: 227-232.
18. Teede HJ, Dalais FS, Kotsopoulos D, Liang YL, Davis S, McGrath BP. Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal. J Clin Endocrinol Metab 2001; 86: 3053-3060.
19. Rivas M, Garay RP, Escanero JF, Cia P Jr, Cia P, Alda JO. Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension. J Nutr 2002; 132: 1900-1902.
20. Hermansen K, Sondergaard M, Hoie L, Carstensen M, Brock B. Beneficial effects of a soy based dietary supplement on lipid levels and cardiovascular risk markers in Type 2 diabetic subjects. Diabetes Care 2001; 24: 228-233.
21. Hodgson JM, Puddey IB, Beilin LJ et al. Effects of isoflavonoids on blood pressure in subjects with high-normal ambulatory blood pressure levels: a randomised controlled trial. Am J Hypertens 1999; 12: 47-53.
22. van Ittersum FJ, van Baal WM, Kenemans P et al. Ambulatory not office blood pressures decline during hormone replacement therapy in healthy postmenopausal women. Am J Hypertens 1998; 11: 1147-1152.
23. Harvey PJ, Wing LM, Savage J, Molloy D. The effects of different types and doses of oestrogen replacement on clinic and ambulatory blood pressure and the renin-angiotensin system in normotensive postmenopausal women. Am J Hypertens 1998; 11: 1147-1152.
24. Collins P, Beale CM, Rosano GM. Oestrogen as a calcium channel blocker. Eur Heart J 1996; 17: 27-31.
25. Sudhir K, Elser MD, Jennings GL, Komesaroff PA. Estrogen supplementation decreases norepinephrine-induced vasoconstriction and total body norepinephrine spillover in perimenopausal women. Hypertension 1997; 30: 1538-1543.
26. Nevala R, Korpela R, Vapaatalo H. Plant derived estrogens relax rat mesenteric artery in vitro. Life Sci 1998; 63: 95-100.
27. Figtree GA, Griffiths H, Lu YQ, Webb CM, MacLeod K, Collins P. Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism. J Am Coll Cardiol 2000; 35: 1977-1985.
28. Howes JB, Sullivan D, Lai N et al. The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolemia. Atherosclerosis 2000; 152: 143-147.
29. Jayagopal V, Albertazzi P, Kilpatrick E, Howarth E. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 2002; 25: 1709-1714.